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Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage pp 81–85Cite as

Beneficial Effect of Selective Intra-arterial Infusion of Fasudil Hydrochloride as a Treatment of Symptomatic Vasospasm Following SAH

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 115))

Abstract

Introduction: We envisage the efficacy and safety of intra-arterial infusion of fasudil hydrochloride (IAF) for symptomatic vasospasm (SVS) after subarachnoid hemorrhage (SAH). We compared results obtained from the groups that received selective IAF (a microcatheter inserted in intracranial arteries) and nonselective IAF (a microcatheter inserted in the cervical arteries). Glasgow Outcome Scale (GOS) value and computed tomographic (CT) score were used to evaluate clinical outcome and the extent of infarction due to delayed vasospasm.

Material and methods: Over 2 years, 113 patients with SAH underwent clipping or coiling. Among them, 31 patients (27.4%) developed SVS. We performed nonselective IAF in 10 patients and selective IAF in 10 other patients. Eleven patients with SVS were treated without IAF. The data were statistically analyzed.

Result: By univariate linear regression analysis, IAF negatively correlated with CT score (p = 0.016), but IAF was significantly correlated with GOS (p = 0.035). By multiple regression analysis, Hunt and Kosnik grade and CT score significantly correlated with GOS.

Discussion: CT score significantly correlated with functional outcome. Although IAF, both selective and nonselective, was significantly effective for the treatment of delayed vasospasm, the former seemed to be more beneficial.

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Conflicts of Interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Saitama Medical Center/Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-8550, Japan

    Takumi Nakamura M.D., Toru Matsui M.D., D.MSc., Atsushi Hosono M.D., Atsushi Okano M.D., Naoaki Fujisawa M.D., Tsukasa Tsuchiya M.D., Masahiro Indo M.D., Yasutaka Suzuki M.D., Soichi Oya M.D., D.MSc. & Han Soo Chang M.D., D.MSc.

Authors
  1. Takumi Nakamura M.D.
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  2. Toru Matsui M.D., D.MSc.
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  3. Atsushi Hosono M.D.
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  4. Atsushi Okano M.D.
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  5. Naoaki Fujisawa M.D.
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  6. Tsukasa Tsuchiya M.D.
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  7. Masahiro Indo M.D.
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  8. Yasutaka Suzuki M.D.
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  9. Soichi Oya M.D., D.MSc.
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  10. Han Soo Chang M.D., D.MSc.
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Corresponding author

Correspondence to Toru Matsui M.D., D.MSc. .

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Editors and Affiliations

  1. , Department of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45267-0515, Ohio, USA

    Mario Zuccarello

  2. College of Medicine, Department of Neurology, University of Cincinnati, Albert Sabin Way 231MSB room 1, Cincinnati, 46267-0536, Ohio, USA

    Joseph F. Clark

  3. College of Medicine, Dept. of Neurology and Neurosurgery, University of Cincinnati, Albert Sabin Way 231ML0517, Cincinnati, 45267-0517, Ohio, USA

    Gail Pyne-Geithman

  4. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson St. Suite 260ML0515, Cincinnati, 45219, Ohio, USA

    Norberto Andaluz

  5. College of Medicine, Dept. of Neurosurgery, University of Cincinnati, Stetson, Suite 2200 260, Cincinnati, 45219, Ohio, USA

    Jed A. Hartings

  6. , Dept. of Emergency Medicine, University of Cincinnati, Albert Sabin Way 231ML0769, Cincinnati, 45267-0769, Ohio, USA

    Opeolu M. Adeoye

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© 2013 Springer-Verlag Wien

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Nakamura, T. et al. (2013). Beneficial Effect of Selective Intra-arterial Infusion of Fasudil Hydrochloride as a Treatment of Symptomatic Vasospasm Following SAH. In: Zuccarello, M., Clark, J., Pyne-Geithman, G., Andaluz, N., Hartings, J., Adeoye, O. (eds) Cerebral Vasospasm: Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement, vol 115. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1192-5_18

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  • DOI: https://doi.org/10.1007/978-3-7091-1192-5_18

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1191-8

  • Online ISBN: 978-3-7091-1192-5

  • eBook Packages: MedicineMedicine (R0)

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