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Microdomain Organization and the Role of Second Messengers

Store-operated Ca2+ Entry: Endogenous Messengers and Mediators

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Store-operated Ca2+ entry (SOCE) pathways

Abstract

Store-operated Ca2+ entry (SOCE) is essential for native cells, and recent discoveries resulted in the molecular identification of STIM1 as a Ca2+ sensor in endoplasmic reticulum, and Orai1 as a plasma membrane channel that is activated by the store-operated pathway. Molecular interactions of over-expressed Orai1 and STIM1 have been extensively studied in the model heterologous systems, but the mechanism of the endogenous signal transduction in native cells is yet to be established. Here we will focus on endogenous messengers and mediators that can be essential for signal transduction from endoplasmic reticulum-resident STIM1 to plasma membrane Orai1 channels. Particularly, we will look at Calcium Influx Factor (CIF) and Ca2+-independent phospholipase A2 (iPLA2β, or PLA2G6), the role of STIM1 as a trigger for CIF production, iPLA2β -mediated effects of CIF on endogenous SOC channels and SOCE, and complex relationship between STIM1 and Orai1 expression, puncta formation and SOCE activation. We will highlight some of the findings that may challenge direct conformational coupling models in native cells, and will offer some new perspectives on the complex relationships between endogenous Orai1, STIM1 and iPLA2β in SOCE pathway.

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  1. Ion Channel and Calcium Signaling Unit, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    Victoria M. Bolotina

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Correspondence to Victoria M. Bolotina .

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  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Bolotina, V.M. (2012). Microdomain Organization and the Role of Second Messengers. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_8

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