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The STIM-Orai Pathway

Orai, the Pore-Forming Subunit of the CRAC Channel

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Abstract

This chapter focuses on the Orai proteins, Orai1-3 in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It starts by reviewing briefly the defining characteristics of the CRAC channel, then discusses the first studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines some insights from cell biological and electrophysiological studies of recombinant Orai proteins.

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Authors and Affiliations

  1. Division of Signalling and Gene Expression, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA

    Patrick G. Hogan

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  1. Patrick G. Hogan
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Correspondence to Patrick G. Hogan .

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Editors and Affiliations

  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Hogan, P.G. (2012). The STIM-Orai Pathway. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_3

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