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New Aspects of the Contribution of ER to SOCE Regulation

TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores

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Book cover Store-operated Ca2+ entry (SOCE) pathways

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Abstract

Transient receptor potential canonical (TRPC) proteins were identified as molecular candidates of receptor- and/or store-operated channels because of their close homology to the Drosophila TRP and TRPL. Functional studies have revealed that TRPC channels play an integrated part of phospholipase C-transduced cell signaling, mediating Ca2+, as well as Na+, influx into cells. As a consequence, the TRPC channels have diverse functional roles in difference cell types, including metabotropic receptor-evoked membrane depolarization and intracellular Ca2+ concentration regulation. Depending on the cellular environment and the protein partners present in the channel complex, the TRPC channels display different biophysical properties and mechanisms of regulation. Despite the controversy on whether or not TRPC channels are store-operated, evidence exists for physical and functional interactions between plasma membrane-localized TRPC channels and proteins involved in sensing and regulating the intracellular Ca2+ store contents, such as inositol trisphosphate receptors, junctate, STIM, and Homer. The interplay among these proteins will likely define the functional significance of TRPC channel activation in different cellular contexts and under different modes of stimulations.

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  1. Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Alexis Bavencoffe & Michael Xi Zhu

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  1. Alexis Bavencoffe
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  2. Michael Xi Zhu
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Correspondence to Michael Xi Zhu .

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  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Bavencoffe, A., Zhu, M.X. (2012). New Aspects of the Contribution of ER to SOCE Regulation. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_12

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