Neuroprotection by Melatonin after Germinal Matrix Hemorrhage in Neonatal Rats
Background: Germinal matrix hemorrhage (GMH) is a devastating neurological disorder of very low birth weight premature infants that leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Melatonin is a potent antioxidant known to reverse free-radical mediated injury in the brain. This study investigated the effect of melatonin treatment after GMH injury.
Methods: Clostridial collagenase was infused into the right germinal matrix region of neonatal rats with stereotaxic technique. Cognitive function, sensorimotor ability, cerebral, cardiac and splenic growths were measured in juvenile animals.
Results: Systemic melatonin treatment ameliorated cognitive and sensorimotor dysfunction at the juvenile developmental stage. This hormone also normalized brain atrophy, splenomegaly, and cardiac hypertrophy consequences at 1 month after injury.
Conclusion: This study supports the role of free radicals in acute neonatal hemorrhagic brain injury. Melatonin is an effective antioxidant that can protect the infant’s brain from the post-hemorrhagic consequences of mental retardation and cerebral palsy. Further mechanistic studies are warranted to determine the mechanisms behind these neuroprotective effects.
- Neuroprotection by Melatonin after Germinal Matrix Hemorrhage in Neonatal Rats
- Book Title
- Intracerebral Hemorrhage Research
- Book Subtitle
- From Bench to Bedside
- pp 201-206
- Print ISBN
- Online ISBN
- Series Title
- Acta Neurochirurgica Supplementum
- Series Volume
- Series ISSN
- Springer Vienna
- Copyright Holder
- Additional Links
- Melatonin ·
- Neurological deficits ·
- Stroke ·
- Industry Sectors
- eBook Packages
- Editor Affiliations
- ID1. , Neurosurgery, Physiology, Loma Linda University
- ID2. School of Medicine, Dept. Neurosurgery, Loma Linda University
- Author Affiliations
- 1. Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, CA, USA
- 2. Department of Psychology, Loma Linda University, School of Medicine, Loma Linda, CA, USA
- 3. Department of Anesthesiology, Loma Linda University, School of Medicine, Loma Linda, CA, USA
- 4. Department of Neurosurgery, Loma Linda University, School of Medicine, Loma Linda, CA, USA
- 5. Department of Physiology, Loma Linda University, School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, CA, USA
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