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Clot Formation, Vascular Repair and Hematoma Resolution After ICH, a Coordinating Role for Thrombin?

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Book cover Intracerebral Hemorrhage Research

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

Following intracerebral hemorrhage (ICH) there is a sequential response involving activation of the coagulation cascade/platelet plug formation, vascular repair, upregulation of endogenous defense mechanisms and clot resolution. How these responses are coordinated and modified by different hematoma sizes has received little attention. This paper reviews evidence that thrombin can modulate and may coordinate the components of the endogenous response. This has potential consequences for treatment of ICH with a number of modalities.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Richard F. Keep, G. Xi, Y. Hua & J. Xiang

  2. Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

    Richard F. Keep

  3. University of Michigan, R5018 Biomedical Science Research Building, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Richard F. Keep

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  1. Richard F. Keep
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  2. G. Xi
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  3. Y. Hua
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  4. J. Xiang
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Corresponding author

Correspondence to Richard F. Keep .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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Keep, R.F., Xi, G., Hua, Y., Xiang, J. (2011). Clot Formation, Vascular Repair and Hematoma Resolution After ICH, a Coordinating Role for Thrombin?. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_12

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_12

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0692-1

  • Online ISBN: 978-3-7091-0693-8

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