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Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies

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Abstract

The pronounced therapy resistance of melanoma remains as an unsolved problem, and induction of apoptosis or sensitization for proapoptotic signals represent suitable targets. Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) proapoptotic pathways have been described, and the better understanding how proapoptotic pathways are blocked in melanoma may provide a basis for the development of new therapeutic strategies.

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Authors and Affiliations

  1. Department of Dermatology and Allergy, Skin Cancer Center Charité, Charité – Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, Berlin, 10117, Germany

    Jürgen Eberle

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  1. Jürgen Eberle
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  2. Lothar F. Fecker
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Correspondence to Jürgen Eberle .

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  1. , Molecular Pathology, Institute of Pathololgy, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany

    Anja Bosserhoff

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Eberle, J., Fecker, L.F. (2011). Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0371-5_10

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