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Inflammation and Atherosclerosis pp 385–396Cite as

Humoral Antibodies

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Abstract

Coronary heart disease (CHD) is the leading cause of morbidity and mortality in the developed world and typically manifests as myocardial infarction, stroke, angina or sudden death between 50 and 60 years of age in men and 60 and 70 years of age in women. CHD accounts for one in four deaths in men and, contrary to popular belief, is the single biggest killer of women in the UK – one in six women die from the condition (British Heart Foundation CHD Statistics 2003). As detailed elsewhere in this volume, atherosclerosis is a chronic inflammatory condition of the vasculature which can manifest itself in a number of ways such as coronary artery disease, peripheral vascular disease and stroke [1]. It is generally considered to arise as a consequence of lipid accumulation, possibly in early age, and a complex relationship between environmental, metabolic and genetic risk factors.

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  1. Immunobiology Research Group, Department of Oncology, The Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK

    A. Graham Pockley

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  1. A. Graham Pockley
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Correspondence to A. Graham Pockley .

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  1. Medical University Innsbruck, Peter-Mayr-Strasse 4 a, Innsbruck, 6020, Austria

    Georg Wick

  2. Laboratory of Autoimmunity, Division of Experimental Pathophysiology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, Innsbruck, 6020, Austria

    Cecilia Grundtman

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Pockley, A.G. (2012). Humoral Antibodies. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_19

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