Auszug
In den letzten Jahren haben sich die Möglichkeiten der kardialen Labordiagnostik wesentlich erweitert. Grundsätzlich können vier Fragestellungen unterschieden werden:
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1.
Diagnostik von myokardialer Gewebszerstörung (in den häufigsten Fällen ischämische Ursache: akutes Koronarsyndrom mit den klinischen Symptomen, die von unstabiler Angina pectoris bis Myokardinfarkt reichen)
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2.
Diagnostik der Herzinsuffizienz
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3.
labordiagnostisch feststellbare Risikofaktoren für Atherosklerose
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4.
molekulargenetische kardiale Prädispositionsdiagnostik
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Literatur
Allgemein
Löffler G (1998) Basiswissen Biochemie mit Pathobiochemie. Springer, Berlin Heidelberg New York
Thomas L (1998) Labor und Diagnose. TH-Books Verlagsgesellschaft mbH, Frankfurt/Main
Speziell
The Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined — A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of Myocardial infarction (2000). Eur Heart J 21: 1502–1513
Wu A H B, Laios I, Green S, Gornet T G, Wong S S, Parmley L, Tonnesen A S, Plaisier B, Orlando R (1994) Immunoassays for serum and urine myoglobin: Myoglobin clearance assessed as a risk factor for acute renal failure. Clin Chem 40(5): 796–802
Halwachs G, Iberer F, Pieber T, Müller H, Tscheliessnigg K H, Tiran A, Sabin K, Wilders-Truschnig M (1996) Troponin T as a marker for postransplantation adaptational problems of the donor heart. J Heart Lung Transplant 15(5): 451–455
Keller T., Zeller T., Peetz D., et al (2009) Sensitive Troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 361(9): 868–877
Antman E M, Milenko J T, Thompson B, Schactman M, McCabe C H, Cannon C P, Fischer G A, Fung A Y, Thompson C, Wybenga D, Braunwald E (1996) Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 335(18): 1342–1349
Galvani M, Ottani F, Ferrini D, Ladenson J H, Destro A, Baccos D, Rusticani F, Jaffe A S (1997) Prognostic influence of elevated values of cardiac troponin I in patients with unstable angina. Circulation 95(8): 2053–2059
Ottani F, Galvani M, Ferrini D, Ladenson J H, Puggioni R, Destro A, Baccos D, Bosi S, Ronchi A, Rusticani F, Jaffe A S (1999) Direct comparison of early elevations of cardiac troponin T in patients with clinical unstable angina. Am Heart J 137(2): 284–291
Kontos M C, Shah R, Fritz L M, Anderson P F, Tatum J L, Ornato J P, Jesse R L (2004) Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients. JACC 43(6): 958–965
Horwich T B, Patel J, MacLellan R, Fonarow G C (2003) Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 108: 833–838
Landesberg G, Shatz V, Akopnik I, Wolf Y G, Mayer M, Berlatzky Y, Weissman C, Mosseri M (2003) Association of cardiac troponin, CK-MB, and postoperative myocardial ischemia with long-term survival after major vascular surgery. JACC 42(9): 1547–1554
Kim L J, Martinez E A, Faraday N, Dorman T, Fleisher L A, Perler B A, Williams M, Chan D, Pronovost P J (2002) Cardiac troponin I predicts short-term mortality in vascular surgery patients. Circulation 106: 2366–2371
Potapov E V, Wagner F D, Loebe M, Ivanitskaia E A, Muller C, Sodia A, Jonitz B, Hetzer R (2003) Elevated donor cardiac troponin T and procalcitonin indicate independent mechanisms of early graft failure after heart transplantation. Int J Cardiol 92(2–3): 163–167
Tate J R, Heathcote D, Rayfield J, Hickman P E (1999) The lack of standardization of cardiac troponin I assay systems. Clin Chim Acta 284: 141–149
Venge P, Lageryvist B, Diderholm E, Lindahl B, Wallentin L (2002) Clinical performance of three cardiac troponin assays in patients with unstable koronary artery disease (a FRISC II substudy). Am J Cardiol 89: 1035–1041
Jossi S., Gordon S.L., Legge M.A., Armstrong G.P. (2006) All troponins are not created equal. Internal Medicine Journal 36: 325–327
Antman E M (2002) Dicision making with cardiac troponin tests. N Engl J Med 346(26): 2079–2082
Apple F S, Wu A H B, Jaffee A S (2002) European society of cardiology and American college of cardiology guidelines for redefinition of myocardial infarction: How to use existing assays clinically and for clinical trials. Am Heart J 144: 981–986
Antmann E. M. et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology /American Heart Association Tsk Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the management of Patients with acute myocardial infarction) ACC/AHA Practice Guidelines 2004; available at www.acc.arg/clinical/guidelines/stemi/index.pdf
Christenson R. H. (2007) Biomarkers of acute koronary syndromes and heart failure. Laboratory Medicine Practice Guidelines of the National Academy of Clinical Biochemistry
Fox K A A, Birkhead J, Wilcox R, Knight C, Barth J (2004) British cardiac society working group on the definition of myocardial infarction. Heart 90: 603–609
Bassand J. P. et al (2007) guidelines for the diagnosis and treatment of non-ST-segment elevation acute koronary syndromes. European Heart Journal 28: 1598–1660
Stewart J T, French J K, Theroux P, Ramanathan K, Solymoss BC, Johnson R, White H D (1998) Early noninvasive identification of failed reperfusion after intravenous thrombolytic therapy in acute myocardial infarction. JACC 31(7): 1499–1505
Laperche T, Golmard J L, Steg P G (1997) Early behavior of biochemical markers in patients with thrombolysis in myocardial infarction grade 2 flow in the infarcted artery as opposed to their flow grades after intravenous thrombolysis for acute myocardial infarction. PERM study group. Prospective evaluation of reperfusion markers. Am Heart J 134(6): 1044–1051
Kragten J A, Hermens W T, van Dieijen-Visser M P (1997) Cumulative troponin T release after acute myocardial infarction. Influence of reperfusion. Eur J Clin Chem Clin Biochem 35(6): 459–467
Veerkamp J H, Maatman R G H J (1995) Cytoplasmic fatty acid-binding proteins: their structure and genes. Prog Lipid Res 34: 17–52
Alhadi H A, Fox K A A (2004) Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein. Q J Med 97: 187–198
Van Nieuwenhoven F A, Kleine A H, Wodzig W H, Hermens W T, Kragten H A, Maessen J G, Punt C D, Van Dieijen M P, Van Der Vusse G J, Glatz J F C (1995) Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Circulation 92: 2848–2854
Wu A H B, Graff L, Petry C, Armstrong G, Prigent F, Brown M (2000) Role of heart-type fatty acid-binding protein in early detection of acute myocardial infarction. Clin Chem 46: 718–719
Gorski J, Hermens W T, Borawski J, Mysliwiec M, Glatz J F C (1997) Increased fatty acid-binding protein concentration in plasma of patients with chronic renal failure. Clin Chem 43: 193a–195a
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult (2001) Executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 guidelines for the evaluation and management of heart failure). Circulation 104: 2996–3007
Levin E R, Gardner D G, Samson W K (1998) Natriuretic peptides. N Engl J Med 339(5): 321–328
Omland T, Aakvaag A, Bonarjee V V S, Caidahl K, Lie R T, Nilsen D W T, Sundsfjord J A, Dickstein K (1996) Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Circulation 93: 1963–1969
McNairy M, Gardetto N, Clopton P, Garcia A, Krishnaswamy P, Kazanegra R, Ziegler M, Maisel A S (2002) Stability of B-type natriuretic peptide levels during acercise in patients with congestive heart failure: Implications for autopatient monitoring with B-type natriuretic peptide. Am Heart J 143:406–411
Loke I, Squire I B, Davies J E, Ng L L (2003) Reference ranges for natriuretic peptides for diagnostic use are dependent on age, gender and heart rate. Europ J Heart Fail 5: 599–606
Redfield M M, Rodeheffer R J, Jacobsen S J, Mahoney D W, Bailey K R, Burnett J C (2002) Plasma brain natriuretic peptide concentration: Impact of age and gender. JACC 40(5): 976–982
Maisel A S, Clopton P, Krishaswamy P, Nowak R M, McCord J, Hollander J E, Duc P, Omland T, Storrow A B, Abraham W T, Wu A H B, Steg G, Westheim A, Knudsen C W, Perez A, Kazanegra R, Bhalla V, Herrmann H C, Aumont M C, McCullough P A (2004) Impact of age, race, and sex on the ability of B-type natriuretic peptide to aid in the emergency diagnosis of heart failure: Results from the breathing not properly (BNP) multinational study. Am Heart J 147: 1078–1084
McCord J, Mundy B J, Hudson M P, Maisel A S, Hollander J E, Abraham W T, Steg P G, Omland T, Knudsen C W, Sandberg K R, McCullough P A (2004) Relationship between obesity and B-type natriuretic peptide levels. Arch Intern Med 164: 2247–2252
McCullough P A, Nowak R M, McCord J, Hollander J E, Herrmann H C, Steg P G, Duc P, Westheim A, Omland T, Knudsen C W, Storrow A B, Abraham W T, Lamba S, Wu A H B, Perez A, Clopton P, Krishnaswamy P, Kazanegra R, Maisel A S (2002) B-Type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure. Circulation 106: 416–422
Dao Q, Krishnaswamy P, Kazanegra R, Harrison A, Amirnovin R, Lenert L, Clopt9n P, Alberto J, Hlavin P, Maisel A S (2001) Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. JACC 37(2): 379–385
Shapiro B P, Chen H H, Burnett J C, Redfield M M (2003) Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure. Mayo Clin Proc 78: 481–486
Maisel A S, Krishaswamy P, Nowak R M, McCord J, Hollander J E, Due P, Omland T, Storrow A B, Abraham W T, Wu A H B, Clopton P, Steg P G, Westheim A, Knudsen C W, Perez A, Kazanegra R, Herrmann H C, McCullough P A (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347(3): 161–167
Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud A P (2004) Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 350(7): 647–654
Hedberg P, Lönnberg I, Jonason T, Nilsson G, Pehrsson K, Ringqvist I (2004) Electrocardiogram and B-type natriuretic peptide as screening tools for left ventricular systolic dysfunction in a population-based sample of 75-year-old men and women. Am Heart J 148: 524–529
Hansen M S, Stanton E B, Gawad Y, Packer M, Pitt B, Swedberg K, Rouleau J L (2002) Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with Flosequin. Am J Cardiol 90: 969–973
Olivetti G, Abbi R, Yuaini F, Kajstury J, Cheng W, Natahara J A, Yuaini E, Di Loreto C, Feltrami C A, Krajewski S, Reed J C, Anversa P (1997) Apoptosis in the failing human heart. N Engl J Med 336(16): 1131–1141
Hillis GS, Zhao N, Taggart P, Dalsey W C, Mangione A (1999) Utility of cardiac troponin I, creatine kinase MB mass, myosin light cahin 1, and myoglobin in the early in-hospital triage of „high risk“ patients with chest pain. Heart 82: 614–620
Isobe M, Nagai R, Ueda S, Tsuchimochi H, Nakaoka H, Takaku F, Yamaguchi T, Machii K, Nobuyoshi M, Yazaki Y (1987) Quantitative relationship between left ventricular function and serum cardiac myosin lieght chain I levels after koronary reperfusion in patients with acute mayocardial infarction. Circulation 76(6): 1251–1261
Katus H A, Diederich K W, Hoberg E, Kubler W (1988) Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subgroup. J Am Coll Cardiol 11(3): 487–493
Kawai Y, Yoshida M, Arakawa K, Kumamoto T, Morikawa N, Masamura K, Tada H, Ito S, Hoshizaki H, Oshima S, Taniguchi K, Terasawa H, Miyamori I, Kishi K, Yasuda T (2004) Diagnostic use of serum deoxyribonucleae I activity as a novel early-phase marker in acute myocardial infarction. Circulation 109: 2398–2400
Yao M, Keogh A, Spratt P, dos Remedios C G, Kiessling P C (1996) Elevated Dnase I levels in human idiopathic dilated cardiomyopathy: an indicator of apoptosis? J Mol Cell Cardiol 28(1): 95–101
Dawber T R, Kannel W B, Revotskie N, Stokes J I, Kagan A, Gordon T (1959) Some factors associated with the development of coronary heart disease; six years’ follow-up experience in the Framingham Study. Am J Public Health 49: 1349–1356
Wilson P W F, D’Agostino R B, Levy D, Belanger A M, Silbershatz H, Kannel W B (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97: 1837–1847
Assmann G, Cullen P, Schulte H (2002) Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study. Circulation 105: 310–315
Ross R, Glomset J A (1976) The pathogenesis of atherosclerosis (first & second part). N Engl J Med 295(7): 369–377 & 295 (8): 420–425
Ervin R B, Wright J D, Wang C Y, Kennedy-Stephenson J (2004) Dietary intake of fats and fatty acids for the United States population: 1999–2000. Advance data from vital and health statistics; no 348. National Center for Health Statistics, Hyattsville, Maryland
Obisesan T O, Aliyu M H, Adediran A S, Bond V, Maxwell C J, Rotimi C N (2004) Correlates of serum lipoprotein (A) in children and adolescents in the United States. The third National Health Nutrition and Examination Survey (NHANES-III). Lipids in Health and Disease 3(29)
Stanger O (2004) Homocystein — Grundlagen, Klinik, Therapie, Prävention. Verlag Wilhelm Maudrich Wien, München, Bern
Benditt E P, Barrett T, McDougall J K (1983) Viruses in the etiology of atherosclerosis. Proc Natl Acad Sci USA 80: 6386–6389
Melnick J L, Adam E, DeBakey M E (1993) Cytomegalovirus and atherosclerosis. Eur Heart J 14[Suppl K]: 30–38
Valantine H A (2004) The role of viruses in cardiac allograft vasculopathy. Am J Transplant 4(2): 169–177
Chiu B, Viira E, Tucker W, Fong IW (1997) Chlamydia pneumonite, cytomegalovirus, and herpes simplex virus in atherosclerosis of the carotid artery. Circulation 96(7): 2144–2148
Latsios G, Saetta A, Michalopoulos N V, Agapitos E, Patsouris E (2004) Detection of cytomegalovirus, Helicobacter pylori and Clamydia pneumoniae DNA in carotid atherosclerotic plaques by the polymerase chain reaction. Acta Cardiol 59(6): 652–657
Marenberg M E, Risch N, Berkman L F, Floderus B, de Faire U (1994) Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330: 1041–1046
Michaels L (1966) Aetiology of coronary artery disease: An historical approach. Br Heart J 28: 258–264
Ryle J A, Russell W T (1949) The natural history of coronary disease: A clinical and epidemiological study. Br Heart J 11: 370–391
Tai E S, Tan C E (2004) Genes, diet and serum lipid concentrations: lessons from ethically diverse populations and their relevance to coronary heart diesease in Asia. Curr Opin Lipidol 15: 5–12
Ordovas J M, Corella D, Demissie S, Cupples A, Couture P, Coltell O, Wilson P W F, Schaefer E J, Tucker K L (2002) Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoteron hght-density lipoprotein metabolism. Circulation 106: 2315–2321
Ilveskoski E, Perola M, Lehtimäki T, Lappala P, Savolainen V, Pajarinen J, Penttilä A, Lalu K H, Männikkö A, Liesto K K, Koivula T, Karhunen P J (1999) Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men. Circulation 100: 608–613
Hong S H, Park W H, Lee C C, Song J H, Kim J Q (1997) Association between genetic variations of aop AI-CIII-AIV cluster gene and hypertriglyceridemic subjects. Clin Chem 43(1): 13–17
Myant N B (1993) Familial defective apopipoprotein B-100:a review, including comparisons with familial hypercholesterolaemia. Atherosclerosis 104(1–2): 1–18
Couture P, Otvos J D, Cupples L A, Wilson P W F, Schaefer E J, Ordovas J M (1999) Association of the A-204C polymorphism in the cholesterol 7α-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. J Lipid Res 40: 1883–1889
Doris P A (2002) Hypertension genetics, single nucleotide polymorphisms, and the common disease: Common variant hypothesis. Hypertension 39: 323–331
Williams M S, Bray P F (2001) Genetics of arterial prothrombotic risk states. Exp Biol Med 226(5): 409–419
Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M (2002) Prediciton of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 347: 1916–1923
Pasotti M, Repetto A, Gavazzi L, Arbustivi E (2004) Genetic predisposition to heart failure. Med Clin N Am 88: 1173–1192
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Halwachs-Baumann, G. (2011). Kardiale Labordiagnostik. In: Labormedizin. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0203-9_3
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