Abstract
The prophylactic administration of antibiotics to prevent infection and the prophylactic administration of anticonvulsants to prevent first seizure episodes are common practice in neurosurgery. If prophylactic medication therapy is not indicated, the patient not only incurs the discomfort and the inconvenience resulting from drug treatment but is also unnecessarily exposed to adverse drug reactions, and incurs extra costs. The main situations in which prophylactic anticonvulsants and antibiotics are used are described and those situations we found controversial in the literature and lack further investigation are identified: anticonvulsants for preventing seizures in patients with chronic subdural hematomas, antiepileptic drugs for preventing seizures in those suffering from brain tumors, antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures, and antibiotic prophylaxis for the surgical introduction of intracranial ventricular shunts.
In the following we present systematic reviews of the literature in accordance with the standard protocol of The Cochrane Collaboration to evaluate the effectiveness of the use of these prophylactic medications in the situations mentioned. Our goal was to efficiently integrate valid information and provide a basis for rational decision-making.
Keywords
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References
Alleyne CH, Hassan M, Zabramski JM (2000) The efficacy and cost of prophylactic and perioprocedural antibiotics in patients with external ventricular drains. Neurosurgery 47: 1124–29
Altman DG, Deeks JJ (2002) Metaanalysis, Simpson’s paradox, and the number needed to treat. BMC Med Res Methodol 2: 3
Ash GJ, Peter J, Bass DH (1992) Antimicrobial prophylaxis for fractured base of skull in children. Brain Inj 6: 521–27
Baker CJ, Prestigiacomo CJ, Solomon RA (1995) Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms. Neurosurgery 37: 863–71
Barker FG (1994) Efficacy of prophylactic antibiotics for craniotomy: a metaanalysis. Neurosurgery 35: 484–92
Barker FG (2002) Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysis. Neurosurgery 51: 391–401
Barker FG (2007) Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta-analysis. Neurosurgery 60: 887–94
Battino D, Tomson T (2007) Management of epilepsy during pregnancy. Drugs 67: 2727–46
Bayston R (1975) Antibiotic prophylaxis in shunt surgery. Dev Med Child Neurol (Suppl) 35: 99–103
Beenen LFM, Lindeboom J, Kasteleijn-Nolst DGA, Heimans JJ, Snoek FJ, Touw DJ, Ader HJ, van Alphen HAM (1999) Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects. J Neurol Neurosurg Psychiatry 67: 474–80
Blomstedt GC (1985) Results of trimethoprim-sulfamethoxazole prophylaxis in ventriculostomy and shunting procedures. A double-blind randomized trial. J Neurosurg 62: 694–97
Blum J, Schwarz M, Voth D (1989) Antibiotic single-dose prophylaxis of shunt infections. Neurosurg Rev 12: 239–44
Bondurant CP, Jimenez DF (1995) Epidemiology of cerebrospinal fluid shunting. Pediatr Neurosurg 23: 254–59
Borges LF (1982) Cerebrospinal fluid shunts interfere with hosts defenses. Neurosurgery 10: 55–60
Brodie HA (1997) Prophylactic antibiotics for posttraumatic cerebrospinal fluid fistulae. A metaanalysis. Arch Otolaryngol Head Neck Surg 123: 749–52
Buchanan RJ, Brant A, Marshall LR (2004) Traumatic cerebrospinal fluid fistulas. In: Winn HR (ed) Youmans Neurological Surgery. Saunders, Philadelphia, pp 5265–72
Bullock R, van Dellen JR, Ketelbey W, Reinach SG (1988) A double-blind placebocontrolled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 69: 687–91
Byrne JV, Boardman P, Ioannidis I, Adcock J, Traill Z (2003) Seizures after aneurysmal subarachnoid hemorrhage treated with coil embolization. Neurosurgery 52: 545–52
Byrne TN, Cascino TL, Posner JB (1983) Brain metastasis from melanoma. J Neurooncol 1: 313–17
Cabral RJ, King TT, Scott DF (1976) Epilepsy after two different neurosurgical approaches to the treatment of ruptured intracranial aneurysm. J Neurol Neurosurg Psychiatry 39: 1052–56
Choi D, Spann R (1996) Traumatic cerebrospinal fluid leakage: risk factors and the use of prophylactic antibiotics. Br J Neurosurg 10: 571–75
Chumnanvej S, Dunn IF, Kim DH (2007) Three-day phenytoin prophylaxis is adequate after subarachnoid hemorrhage. Neurosurgery 60: 99–102
Claus BC (2004) Shunt infection. In: Winn HR (ed) Youmans Neurological Surgery. Saunders, Philadelphia, pp 3419–25
Clemenza JW, Kaltman SI, Diamond DL (1995) Craniofacial trauma and cerebrospinal fluid leakage: a retrospective clinical study. J Oral Maxillofac Surg 53: 1004–07
Cockey GH, Amann ST, Reents SB, Lynch JB Jr (1996) Stevens-Johnson syndrome resulting from whole-brain radiation and phenytoin (Abstract). Am J Clin Oncol 19: 32–34
Dagi TF, Meyer FB, Poletti CA (1983) The incidence and prevention of meningitis after basilar skull fracture. Am J Emerg Med 1: 295–98
De Santis A, Villani R, Sinisi M, Stocchetti N, Perucca E (2002) Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumours: a randomized controlled study. Epilepsia 43: 175–82
Demetriades D, Charalambides D, Lakhoo M, Pantanowitz D (1992) Role of prophylactic antibiotics in open and basilar fractures of the skull: a randomized study. Injury 23: 377–80
Deutschman CS, Haines SJ (1985) Anticonvulsant prophylaxis in neurological surgery. Neurosurgery 17: 510–17
Dickersin K, Scherer R, Lefebvre C (1994) Identifying relevant studies for systematic reviews. BMJ 309: 1286–91
Djindjian M, Fevrier MJ, Otterbein G, Soussy JC (1986) Oxacillin prophylaxis in cerebrospinal fluid shunt procedures: results of a randomized open study in 60 hydrocephalic patients. Surg Neurol 25: 178–80
Eftekhar B, Ghodsi M, Nejat F, Ketabchi E, Esmaeeli B (2004) Prophylactic administration of ceftriaxone for the prevention of meningitis after traumatic pneumocephalus: results of a clinical trial. J Neurosurg 101: 757–61
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in metaanalysis detected by a simple, graphical test. BMJ 315: 629–34
Einhorn A, Mizrahi EM (1978) Basilar skull fractures in children. The incidence of CNS infection and the use of antibiotics. Am J Dis Child 132: 1121–24
Eljamel MS (1993) Antibiotic prophylaxis in unrepaired CSF fistulae. Br J Neurosurg 7: 501–05
Epstein MH, Kumor K, Hughes W, Lietman P (1982) Use of prophylactic antibiotics in pediatric shunting operations — a double-blind prospective study. In: Presented at the American Association of Neurological Surgeons 1982 Annual Meeting
Forsyth PA, Weaver S, Fulton D, Brasher PM, Sutherland G, Stewart D, Hagen NA, Barnes P, Cairncross JG, DeAngelis LM (2003) Prophylactic anticonvulsants in patients with brain tumour. Can J Neurol Sci 30: 106–12
Foy PM, Chadwick DW, Raigopalan N, Johnson AL, Shaw, MDM (1992) Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy? J Neurol Neurosurg Psychiatry 55: 753–57
Franceschetti S, Binelli S, Casazza M, Croci D, Lodrini S, Panzica F, Solero CL, Avanzini G (1988) Crisi postoperatorie in pazienti operati per neoplasie sopratentoriali: studio prospettico. [Postoperative seizures in patients operated on supra-tentorial neoplasms: a prospective study.] Bolletino della Lega Italiana contro l’Epilepsia62–63: 413–15
Franceschetti S, Binelli S, Casazza M, Lodrini S, Panzica F, Pluchino F, Solero CL, Avanzini G (1990) Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochir (Wien) 103: 47–51
Frazee RC, Mucha P Jr, Farnell MB, Ebersold MJ (1988) Meningitis after basilar skull fracture. Does antibiotic prophylaxis help? Postgrad Med 83: 267–74
Friedman JA, Ebersold MJ, Quast LM (2001) Post-traumatic cerebrospinal fluid leakage. World J Surg 25: 1062–66
Glantz M, Recht LD (1997) Epilepsy in the cancer patient. In: Vinken PJ, Bruyn GW (eds) Handbook of Neurology: Neuro-Oncology, Vol. 25. Elsevier, Amsterdam, pp 9–18
Glantz MJ, Cole BF, Forsyth PA, Recht LD, Wen PY, Chamberlain MC (2000) Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumours. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 54: 1886–93
Glantz MJ, Cole BF, Friedberg MH, Lathi E, Choy H, Furie K, Akerley W, Wahlberg L, Lekos A, Louis S (1996) A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumours. Neurology 46: 985–91
Gonzalez JL (1998) Profilaxis con antibioticos en fracturas de base de craneo. Tiene justification esa conducta? [Antibiotic prophylaxis in basilar skull fractures. Is it worth it?] Revista Cubana de Cirugi’a 37: 5–9
Govender ST, Nathoo N, van Dellen JR (2003) Evaluation of an antibiotic-impregnated shunt system for the treatment of hydrocephalus. J Neurosurg 99: 831–39
Grisoli F, Graziani N, Peragut JC, Vincentelli F, Fabrizi AP, Caruso G, Bellard S (1988) Perioperative lumbar injection of Ringer’s lactate solution in chronic subdural hematomas: a series of 100 cases. Neurosurgery 23: 616–21
Grossman SA, Sheidler VR, Gilbert MR (1989) Decreased phenytoin levels in patients receiving chemotherapy. Am J Med 87: 505–10
Haines SJ, Taylor F (1982) Prophylactic methicillin for shunt operations: effects on incidence of shunt malfunction and infection. Childs Brain 9: 10–22
Haines SJ, Walters BC (1994) Antibiotic prophylaxis for cerebrospinal fluid shunts: a metaanalysis. Neurosurgery 34: 87–92
Helling TS, Evans LL, Fowler DL, Hays LV, Kennedy FR (1988) Infectious complications in patients with severe head injury. J Trauma 28: 1575–77
Higgins JPT, Green S (2008) Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration. Available from www.cochrane-handbook.org
Hirakawa K, Hashizume K, Fuchinoue T, Takahashi H, Nomura K (1972) Statistical analysis of chronic subdural hematoma in 309 adult cases. Neurol Med Chir (Tokyo) 12: 71–83
Hoff JT, Brewin A, Hoi Sang U (1976) Letter: antibiotics for basilar skull fracture. J Neurosurg 44: 649
Holland JB, Stapleton SR, Moore AJ, Marsh HT, Uttley D, Bell BA (1995) A randomised double blind study of sodium valproate for the prevention of seizures in neurosurgical patients. J Neurol Neurosurg Psychiatry 58: 116
Ignelzi R, VanderArk G (1975) Analysis of the treatment of basilar skull fractures with and without antibiotics. J Neurosurg 43: 721–26
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17: 1–12
Ketz E (1976) Brain tumours and epilepsy. In: Vinken PJ, Bruyn GW (eds) Handbook of Clinical Neurology, Vol. 16. North-Holland Publishing Company, Amsterdam, pp 254–69
Klastersky J, Sadeghi M, Brihaye J (1976) Antimicrobial prophylaxis in patients with rhinorrhea or otorrhea: a double blind study. Surg Neurol 6: 111–14
Kotwica Z, Brzezinski J (1991) Epilepsy in chronic subdural haematoma. Acta Neurochir (Wien) 113: 18–20
Lackner TE (1991) Interaction of dexamethasone with phenytoin. Pharmacotherapy 11: 344–47
Langley JM, LeBlanc JC, Drake J, Milner R (1993) Efficacy of antimicrobial prophylaxis in placement of cerebrospinal fluid shunts: metaanalysis. Clin Infect Dis 17: 98–103
Lee ST, Lui TN, Chang CN, Cheng WC, Wang DJ, Heimburger RF, Lin CG (1989) Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surg Neurol 31: 361–64
Leech PJ, Paterson A (1973) Conservative and operative management of cerebrospinal fluid leakage after closed head injury. Lancet 1: 1013–15
Lehmann DF, Hurteau TE, Newman N, Coyle TE (1997) Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumours. Clin Pharmacol Ther 62: 225–29
Levati A, Savoia G, Zoppi F, Boselli L, Tommassino C (1996) Peri-operative prophylaxis with phenytoin: dosage and therapeutic levels. Acta Neurochir (Wien) 138: 274–78
Lin CL, Dumont AS, Lieu AS, Yen CP, Hwang SL, Kwan AL, Kassell NF, Howng SL (2003) Characterization of perioperative seizures and epilepsy following aneurysmal subarachnoid hemorrhage. J Neurosurg 99: 978–85
Loring DW, Meador KJ (2004) Cognitive side effects of antiepileptic drugs in children. Neurology 62: 872–77
Luxon LM, Harrison MJG Luxon LM, Harrison MJG (1979) Chronic subdural haematoma. Q J Med 48: 43–53
MacGee EE, Cauthen JC, Brackett CE (1970) Meningitis following acute traumatic cerebrospinal fluid fistula. J Neurosurg 33: 312–16
McGuirt WF Jr, Stool SE (1995) Cerebrospinal fluid fistula: the identification and management in pediatric temporal bone fractures. Laryngoscope 105: 359–64
McKissock W, Richardson A, Bloom WH (1960) Subdural haematoma. A review of 389 cases. Lancet 1: 1365–69
Mecarelli O, Vicenzini E, Pulitano P, Vanacore N, Romolo FS, Di Piero V, Lenzi GL, Accornero N (2004) Clinical, cognitive, and neurophysiologic correlates of short-term treatment with carbamazepine, oxcarbazepine, and levetiracetam in healthy volunteers. Ann Pharmacother 38: 1816–22
Moss AJ, Hamburger S, Moore RM Jr, Jeng LL, Howie LJ (1991) Use of selected medical device implants in the United States, 1988. Adv Data 191: 1–24
Nakamura N, Ishijima B, Mayanagi Y, Manaka S (1999) A randomized controlled trial of zonisamide in postoperative epilepsy: a report of the Cooperative Group Study. Jpn J Neurosurg 8: 647–56
Nathoo N, Govender ST, Barnett GH, van Dellen JR (2004) Evaluation of an antimicrobial impregnated shunt system for the treatment of hydrocephalus. In: Presented at the American Association of Neurological Surgeons 2004 Annual Meeting
Neef C, Voogd-van der Straaten I (1988) An interaction between cytostatic and anticonvulsant drugs. Clin Pharmacol Ther 43: 372–75
Neuwelt EA, Kikuchi K, Hill S, Lipsky P, Frenkel EP (1983) Immune responses in patients with brain tumours. Factors such as anti-convulsants that may contribute to impaired cellmediated immunity. Cancer 51: 248–55
North JB, Penhall RK, Hanieh A, Frewin DB, Taylor WB (1983) Phenytoin and postoperative epilepsy. A double-blind study. J Neurosurg 58: 672–77
North JB, Penhall RK, Hanieh A, Hann CS, Challen RG, Frewin DB (1980) Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. Lancet 1: 384–86
Odio C, Mohs E, Sklar FH, Nelson JD, McCracken GH (1984) Adverse reactions to vancomycin used as prophylaxis for CSF shunts procedures. AJDC 138: 17–19
Ohno K, Maehara T, Ichimura K, Suzuki R, Hirakawa K, Monma S (1993) Low incidence of seizures in patients with chronic subdural haematoma. J Neurol Neurosurg Psychiatry 56: 1231–33
Pagani JJ, Hayman LA, Bigelow RH, Libshitz HI, Lepke RA, Wallace S (1983) Diazepam prophylaxis of contrast media-induced seizures during computed tomography of patients with brain metastases. Am J Roentgenol 140: 787–92
Pagani JJ, Hayman LA, Bigelow RH, Libshitz HI, Lepke RA (1984) Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. Cancer 54: 2200–04
Papazisis G, Kallaras K, Kaiki-Astara A, Pourzitaki C, Tzachanis D, Dagklis T, Kouvelas D (2008) Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. Int J Neuropsychopharmacol 11: 321–29
Pennybacker JB, Taylor M, Cairns H (1947) Penicillin in the prevention of infection during operations on the brain and spinal cord. Lancet 2: 159–62
Petignat C, Francioli P, Harbarth S, Regli L, Porchet F, Reverdin A, Rilliet B, de Tribolet N, Pannatier A, Pittet D, Zanetti G (2008) Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. Spine 33: 1919–24
Pons VG, Denlinger SL, Guglielmo BJ, Octavio J, Flaherty J, Derish PA, Wilson CB (1993) Ceftizoxime versus vancomycin and gentamicin in neurosurgical prophylaxis: a randomized, prospective, blinded clinical study. Neurosurgery 33: 416–22
Prabhu S, Zauner A, Bullock M (2004) Surgical management of traumatic brain injury. In: Winn HR (ed) Youmans Neurological Surgery. Saunders, Philadelphia, pp 5145–80
Price DJ, Sleigh JD (1970) Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics. Lancet 2: 1213–15
Raskind R. Cerebrospinal fluid rhinorrhea and otorrhea (1965) Diagnosis and treatment in 35 cases. J Int Coll Surg 43: 141–54
Ratilal B, Costa J, Sampaio C (2005) Anticonvulsants for preventing seizures in patients with chronic subdural haematoma. Cochrane Database Syst Rev 3: CD004893
Ratilal B, Costa J, Sampaio C (2006) Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database Syst Rev 1: CD004884
Ratilal B, Costa J, Sampaio C (2006) Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts. Cochrane Database Syst Rev 3: CD005365
Ratilal B, Costa J, Sampaio C (2008) Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts: a systematic review. J Neurosurg Pediatr 1: 48–56
Review Manager (RevMan) [Computer Program] (2004) Version 4.2 for Windows. The Cochrane Collaboration, Oxford, England
Rhoney DH, Tipps LB, Murry KR, Basham MC, Michael DB, Coplin WM (2000) Anticonvulsant prophylaxis and timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology 55: 258–65
Rieder MJ, Frewen TC, Del Maestro RF, Coyle A, Lovell S (1987) The effect of cephalothin prophylaxis on postoperative ventriculoperitoneal shunt infections. CMAJ 36: 935–38
Rocca B, Mallet MN, Scemama F, Malca S, Chevalier A, Gouin F (1992) Infections a distance du foyer operatoire en neurochirurgie. Role de l’antibioprophylaxie. [Perioperative remote infections in neurosurgery. Role of antibiotic prophylaxis.] Presse Med 21: 2037–40
Rosengart AJ, Huo JD, Tolentino J, Novakovic RL, Frank JI, Goldenberg FD, Macdonald RL (2007) Outcome in patients with subarachnoid hemorrhage treated with antiepileptic drugs. J Neurosurg 107: 253–60
Rubin G, Rappaport ZH (1993) Epilepsy in chronic subdural haematoma. Acta Neurochir (Wien) 123: 39–42
Sabo RA, Hanigan WC, Aldag JC (1995) Chronic subdural hematomas and seizures: the role of prophylactic anticonvulsive medication. Surg Neurol 43: 579–82
Schierhout G, Roberts I (2001) Antiepileptic drugs for preventing seizures following acute traumatic brain injury. Cochrane Database Syst Rev 4: CD000173
Schmidt K, Gjerris F, Osgaard O, Hvidberg EF, Kristiansen JE, Dahlerup B, Kruse-Larsen C (1985) Antibiotic prophylaxis in cerebrospinal fluid shunting: a prospective randomized trial in 152 hydrocephalic patients. Neurosurgery 17: 1–5
Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273: 408–12
Shapiro M, Wald U, Simchen E, Pomeranz S, Zagzag D, Michowiz SD, Samuel-Cahn E, Wax Y, Shuval R, Kahane Y, Sacks T, Shalit M (1986) Randomized clinical trial of intraoperative antimicrobial prophylaxis of infection after neurosurgical procedures. J Hosp Infect 8: 283–95
Simon TD, Riva-Cambrin J, Srivastava R, Bratton SL, Dean JM, Kestle JR; Hydrocephalus Clinical Research Network (2008) Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths. J Neurosurg Pediatr 1: 131–37
Siomin V, Angelov L, Li L, Vogelbaum MA (2005) Results of a survey of neurosurgical practice patterns regarding the prophylactic use of anti-epilepsy drugs in patients with brain tumors. J Neurooncol 74: 211–15
Siqueira MG, Koury LS, Silva AD, Jabur A, Rezende Filho CP (1987) Profilaxia antibiotica transoperatoria em neurocirurgia: estudo prospectivo controlado. [Intraoperative antibiotic prophylaxis in neurosurgery: a randomized controlled clinical trial.] Arq Bras Neurocirurg 6: 5–12
Smith DB (1991) Cognitive effects of antiepileptic drugs. Adv Neurol 55: 197–212
Steidtmann K, Welge-Lussen A, Probst R (1997) Antibiotikaprophylaxe bei laterobasalen Frakturen. [Antibiotic prophylaxis in laterobasal fractures.] HNO 45: 448–52
Stenager E, Gerner-Smidt P, Kock-Jensen C (1986) Ventriculostomy-related infections: an epidemiological study. Acta Neurochir (Wien) 83: 20–23
Tos M (1973) Course of and sequelae to 248 petrosal fractures. Acta Otolaryngol 75: 353–54
Tremont-Lukats IW, Ratilal BO, Armstrong T, Gilbert MR (2008) Antiepileptic drugs for preventing seizures in people with brain tumors. Cochrane Database Syst Rev 2: CD004424
Tremont-Lukats IW, Teixeira GM (2002) Anticonvulsant prophylaxis in patients with brain tumours: an overview. Neuro-oncol 4: S97
Vecht CJ, van Breemen M (2006) Optimizing therapy of seizures in patients with brain tumors. Neurology 4: 10–13
Villalobos T, Arango C, Kubilis P, Rathore M (1998) Antibiotic prophylaxis after basilar skull fractures: a metaanalysis. Clin Infect Dis 27: 364–69
Vining EP, Mellitis ED, Dorsen MM, Cataldo MF, Quaskey SA, Spielberg SP, Freeman JM (1987) Psychologic and behavioral effects of antiepileptic drugs in children: a double-blind comparison between phenobarbital and valproic acid. Pediatrics 80: 165–74
Walters BC, Goumnerova L, Hoffman HJ, Hendrick EB, Humphreys RP, Levinton C (1992) A randomized controlled trial of perioperative rifampin/trimethoprim in cerebrospinal fluid shunt surgery. Childs Nerv Syst 8: 253–57
Wang EE, Prober CG, Hendrick BE, Hoffman HJ, Humphreys RP (1984) Prophylactic sulfamethoxazole and trimethoprim in ventriculoperitoneal shunt surgery. A double-blind, randomized, placebo-controlled trial. JAMA 251: 1174–77
Wen PY, Marks PW (2002) Medical management of patients with brain tumours. Curr Opin Oncol 14: 299–307
Whitby M, Johnson BC, Atkinson RL, Stuart G (2000) The comparative efficacy of intravenous cefotaxime and trimethoprim/sulfamethoxazole in preventing infection after neurosurgery: a prospective, randomized study. Brisbane Neurosurgical Infection Group. Br J Neurosurg 14: 13–18
Yogev R (1985) Cerebrospinal fluid shunt infections: a personal view. Pediatr Infect Dis 4: 113–18
Young B, Rapp RP, Norton JA, Haack D, Tibbs PA, Bean JR (1983) Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures. J Neurosurg 58: 231–35
Young RF, Lawner PM (1987) Perioperative antibiotic prophylaxis for prevention of postoperative neurosurgical infections. A randomized clinical trial. J Neurosurg 66: 701–05
Zabramski JM, Whiting D, Darouiche RO, Horner TG, Olson J, Robertson C, Hamilton AJ (2003) Efficacy of antimicrobial-impregnated external ventricular drain catheters: a prospective, randomized, controlled trial. J Neurosurg 98: 725–30
Zentner J, Gilsbach J, Felder T (1995) Antibiotic prophylaxis in cerebrospinal fluid shunting: a prospective randomized trial in 129 patients. Neurosurg Rev 18: 169–72
Zhang Y, Zhou LF, Du GH, Gao L, Xu B, Xu J, Gu YX (2000) Phenytoin or sodium valproate for prophylaxis of postoperative epilepsy: a randomized comparison. Chin J Nerv Ment Dis 26: 231–33
Zrebeet HA, Huang PS (1986) Prophylactic antibiotics in the treatment of fractures at the base of the skull. Del Med J 58: 741–48
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Ratilal, B., Sampaio, C. (2011). Prophylactic antibiotics and anticonvulsants in neurosurgery. In: Pickard, J.D., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 36. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0179-7_6
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