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The Use of Field-Flow Fractionation for the Analysis of Drug and Gene Delivery Systems

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Field-Flow Fractionation in Biopolymer Analysis

Abstract

An increasingly large number of drug formulations consist of drug-loaded nanoparticles of controlled size, composition, and surface chemistry. Field-flow fractionation (FFF) has emerged as a powerful tool for the physico-chemical characterization of nanoparticulate drug and gene delivery systems. The enabling features and technical difficulties of FFF are assessed in the specific context of drug formulations. The FFF analysis of various classes of drug and gene delivery systems are described, including microspheres, solid lipid nanoparticles, melt extrudates, emulsions, dendrimers, nanogels, lipid/DNA complexes, and polycation/DNA complexes.

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Authors and Affiliations

  1. Department of Chemistry and Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada

    Alexandre Moquin & Françoise M. Winnik

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  1. Alexandre Moquin
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  2. Françoise M. Winnik
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Correspondence to Françoise M. Winnik .

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Editors and Affiliations

  1. Colorado School of Mines, Golden Colorado, 80401, Colorado, USA

    S. Kim R. Williams

  2. Department of Physical and Analytical Chemistry, Section of, Uppsala, 751 23, Sweden

    Karin D. Caldwell

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Moquin, A., Winnik, F.M. (2012). The Use of Field-Flow Fractionation for the Analysis of Drug and Gene Delivery Systems. In: Williams, S., Caldwell, K. (eds) Field-Flow Fractionation in Biopolymer Analysis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0154-4_13

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