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Cell-Mediated Immunity

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Human and Animal Relationships

Part of the book series: The Mycota ((MYCOTA,volume 6))

Abstract

CMI responses are key host protective responses against mycotic agents. Thus, to comprehend fully the means by which fungal pathogens are eliminated from the body, it is important to understand thoroughly the interactions of the cells with cell-produced soluble factors (cytokines) that are involved in the CMI response directed against the specific fungal pathogen. Like all immune responses, any given CMI response must be induced in the host by the specific organism before it is functional. This means that if the host has not previously encountered the specific fungus, then the host will not have memory T cells directed toward that organism and will not display a specific CMI response against that fungal agent. However, upon first entry of the organism into the body, the immunocompetent host generally develops a CMI response directed against the fungus.

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References

  • Akbar AN, Salmon M, Janossy G (1991) The synergy between naive and memory T cells during activation. Immunol Today 12:184–188

    PubMed  CAS  Google Scholar 

  • Akbar AN, Salmon M, Savill J, Janossy G (1993) A possible role for bcl-2 in regulating T-cell memory -a “balancing act” between cell death and survival. Immunol Today 14:526–532

    PubMed  CAS  Google Scholar 

  • Ampel NM, Bejarano GC, Salas SD, Galgiani JN (1992) In vitro assessment of cellular immunity in human coccidioidomycosis: relationship between dermal hypersensitivity, lymphocyte transformation, and lymphokine production by peripheral blood mononuclear cells from healthy adults. J Infect Dis 165:710–715

    PubMed  CAS  Google Scholar 

  • Ampel NM, Dols CL, Galgiani JN (1993) Coccidioidomycosis during human immunodeficiency virus infection: results of a prospective study in a coccidioidal endemic area. Am J Med 94:235–240

    PubMed  CAS  Google Scholar 

  • Arnaiz-Villena A, Timon M, Rodriguez-Gallego C, Perez-Bias M, Corell A, Martin-Villa JM, Regueiro JR (1992) Human T-cell activation deficiencies. Immunol Today 13:259–265

    PubMed  CAS  Google Scholar 

  • Ashman RB (1990) Murine candidiasis: cell-mediated immune responses correlate directly with susceptibility and resistance to infection. Immunol Cell Biol 68:15–20

    PubMed  Google Scholar 

  • Ashman RB, Papadimitriou JM (1990) What’s new in the mechanisms of host resistance to Candida albicans infection? Path Res Pract 186:527–534

    PubMed  CAS  Google Scholar 

  • Atkinson AJ, Bennett JE (1968) Experience with a new skin test antigen prepared from Cryptococcus neoformans. Am Rev Respir Dis 97:637–643

    PubMed  Google Scholar 

  • Balish E, Filutowicz H, Oberley TD (1990) Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun 58:107–113

    PubMed  CAS  Google Scholar 

  • Beaman L (1987) Fungicidal activation of murine macrophages by recombinant gamma interferon. Infect Immun 55:2951–2955

    PubMed  CAS  Google Scholar 

  • Beaman L, Pappagianis D, Banjamini E (1977) Significance of T cells in resistance to experimental murine coccidioidomycosis. Infect Immun 17:580–585

    PubMed  CAS  Google Scholar 

  • Beaman L, Pappagianis D, Banjamini E (1979) Mechanisms of resistance to infection with Coccidioides immitis in mice. Infect Immun 23:681–685

    PubMed  CAS  Google Scholar 

  • Beaman L, Banjamini E, Pappagianis D (1981) Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro. Infect Immun 34:347–353

    PubMed  CAS  Google Scholar 

  • Beaman L, Banjamini E, Pappagianis D (1983) Activation of macrophages by lymphokines: enhancement of phagosome-lysosome fusion and killing of Coccidioides immitis. Infect Immun 39:1201–1207

    PubMed  CAS  Google Scholar 

  • Bennett JE, Hasenclever HF, Baum GL (1965) Evaluation of a skin test for cryptococcosis. Am Rev Respir Dis 91:616

    PubMed  CAS  Google Scholar 

  • Bistoni F, Cenci E, Mencacci A, Schiaffella E, Mosci P, Puccetti P, Romani L (1993) Mucosal and systemic T helper cell function after intragastric colonization of adult mice with Candida albicans. J Infect Dis 168: 1449–1457

    PubMed  CAS  Google Scholar 

  • Blackstock R, Hall NK (1984) Nonspecific immune suppression by Cryptococcus neoformans infection. My-copathologia 86:35–43

    CAS  Google Scholar 

  • Blackstock R, Hernandez NC (1988) Inhibition of phagocytosis in cryptococcosis: phenotypic analysis of the suppressor cell. Cell Immunol 114:174–187

    PubMed  CAS  Google Scholar 

  • Blackstock R, Hernandez NC (1989) Characterization of the macrophage subset affected and its response to a T suppressor factor (TsFmp) found in cryptococcosis. Infect Immun 57:2931–2937

    PubMed  CAS  Google Scholar 

  • Blackstock R, McCormack JM, Hall NK (1987) Induction of a macrophage-suppressive lymphokine by soluble cryptococcal antigens and its association with models of immunological tolerance. Infect Immun 55:233–239

    PubMed  CAS  Google Scholar 

  • Blackstock R, Hall NK, Hernandez NC (1989) Characterization of a suppressor factor that regulates macrophage phagocytosis in murine cryptococcosis. Infect Immun 57:1773–1779

    PubMed  CAS  Google Scholar 

  • Blackstock R, Zembala M, Asherson GL (1991a) Functional equivalence of cryptococcal and hapten-specific T suppressor factor (TsF). I. Picryl and oxazolone-specific TsF, which inhibit transfer of contact sensitivity also inhibit phagocytosis by a subset of macrophages. Cell Immunol 136:435–447

    PubMed  CAS  Google Scholar 

  • Blackstock R, Zembala M, Asherson GL (1991b) Functional equivalence of cryptococcal and hapten-specific T suppressor factor (TsF). II. Monoclonal anti-crypto-coccal TsF inhibits both phagocytosis by a subset of macrophages and transfer of contact sensitivity. Cell Immunol 136:448–461

    PubMed  CAS  Google Scholar 

  • Blanchard DK, Michelini-Norris MB, Djeu JY (1991) Production of granulocyte macrophage colony-stimulating factor by large granular lymphocytes stimulated with Candida albicans: role in activation of human neutrophil function. Blood 77:2259–2265

    PubMed  CAS  Google Scholar 

  • Blasi E, Farinelli S, Varesio L, Bistoni F (1990) Augmentation of GG2EE macrophage cell line-mediated anti-Candida activity by gamma interferon, tumor necrosis factor and interleukin-1. Infect Immun 58: 1073–1077

    PubMed  CAS  Google Scholar 

  • Brummer E, Stevens DA (1987) Activation of pulmonary macrophages for fungicidal activity by gamma-interferon or lymphokines. Clin Exp Immunol 70:520–528

    PubMed  CAS  Google Scholar 

  • Brummer E, Beaman L, Stevens DA (1985) Killing of endospores, but not arthroconidia, of Coccidioides immitis by immunologically activated polymorphonuclear neutrophils. In: Einstein HE, Catanzaro A (eds) Proc 4th Int Conf Coccidioidomycosis, National Foundation for Infectious Disease, Washington, DC, pp 201–213

    Google Scholar 

  • Brunda MJ (1994) Interleukin-12. J Leukoc Biol 55:280–288

    PubMed  CAS  Google Scholar 

  • Buchanan KL, Murphy JW (1993) Characterization of cellular infiltrates and cytokine production during the expression phase of the anticryptococcal delayed-type hypersensitivity response. Infect Immun 61:2854–2865

    PubMed  CAS  Google Scholar 

  • Buchanan KL, Murphy JW (1994) Regulation of cytokine production during the expression phase of the anticryptococcal delayed-type hypersensitivity response. Infect Immun 62:2930–2939

    PubMed  CAS  Google Scholar 

  • Buchanan KL, Fidel PL Jr, Murphy JW (1991) Effects of Cryptococcus neoformans-specific suppressor T cells on the amplified anticryptococcal delayed-type hypersensitivity response. Infect Immun 59:29–35

    PubMed  CAS  Google Scholar 

  • Buckley RH, Lucas ZJ, Hattler ßG Jr, Zmijewski CJ, Amos DB (1968) Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botromycosis: immunologic reconstitution by allogeneic bone marrow. Clin Exp Immunol 3:153–169

    PubMed  CAS  Google Scholar 

  • Bullock WE, Wright SD (1987) Role of adherence-promoting receptors, CR3, LFA-1, and pl50,95 in binding of Histoplasma capsulatum by human macrophages. J Exp Med 165:195–210

    PubMed  CAS  Google Scholar 

  • Cantorna MT, Balish E (1990) Mucosal and systemic candidiasis in congenitally immunodeficient mice. Infect Immun 58:1093–1100

    PubMed  CAS  Google Scholar 

  • Cantorna MT, Balish E (1991) Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun 59: 2447–2455

    PubMed  CAS  Google Scholar 

  • Catanzaro A (1981) Suppressor cells in coccidioidomycosis. Cell Immunol 64:235–245

    PubMed  CAS  Google Scholar 

  • Catanzaro A, Spitler LE, Moser KM (1975) Cellular immune response in coccidioidomycosis. Cell Immunol 15:360–371

    PubMed  CAS  Google Scholar 

  • Cauley LK, Murphy JW (1979) Response of congenitally athymic (nude) and phenotypically normal mice to Cryptococcus neoformans infection. Infect Immun 23: 644–651

    PubMed  CAS  Google Scholar 

  • Cenci E, Romani L, Vecchiarelli A, Puccetti P, Bistoni F (1989) Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Infect Immun 57:3581–3587

    PubMed  CAS  Google Scholar 

  • Cenci E, Romani L, Vecchiarelli A, Puccetti P, Bistoni F (1990) T cell subsets and IFN-γ production in resistance to systemic candidosis in immunized mice. J Immunol 144:4333–4339

    PubMed  CAS  Google Scholar 

  • Cenci E, Romani L, Mencacci A, Spaccapelo R, Schiaffella E, Puccetti P, Bistoni F (1993) Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur J Immunol 23:1034–1038

    PubMed  CAS  Google Scholar 

  • Chavin KD, Bromberg JS, Kunkel SL, Naji A, Baker CF (1991) Effects of a polyclonal anti-TNF antibody on cell-mediated immunity in vivo. Transplant Proc 23:847–848

    PubMed  CAS  Google Scholar 

  • Chen GH, Curtis JL, Mody CH, Christensen PJ, Armstrong LR, Toews GB (1994) Effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on rat alveolar macrophage anticryptococcal activity in vitro. J Immunol 152:724–734

    PubMed  CAS  Google Scholar 

  • Clemons KV, Brummer E, Stevens DA (1994) Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis Antimicrob Agents Chemother 38:360–464

    Google Scholar 

  • Clerici M, Shearer GM (1993) A Thl → Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 14:107–111

    PubMed  CAS  Google Scholar 

  • Cohen JJ, Duke RC (1992) Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267–293

    PubMed  CAS  Google Scholar 

  • Collins HL, Bancroft GJ (1992) Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factor-a and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans. Eur J Immunol 22:1447–1454

    PubMed  CAS  Google Scholar 

  • Converse JL, Castleberry MW, Snyder EM (1963) Experimental viable vaccine against pulmonary coccidioidomycosis in monkeys. J Bacteriol 86:1041–1051

    PubMed  CAS  Google Scholar 

  • Cox FEG, Liew FY (1992) T-cell subsets and cytokines in parasitic infections. Immunol Today 13:445–448

    PubMed  CAS  Google Scholar 

  • Cox RA (1993) Coccidioidomycosis. In: Murphy JW, Friedman H, Bendinelli M (eds) Fungal infections and immune responses. Plenum Press, New York, pp 173–211

    Google Scholar 

  • Cox RA, Kennell W (1988) Suppression of T-lymphocyte response by Coccidioides immitis antigen. Infect Immun 56:1424–1429

    PubMed  CAS  Google Scholar 

  • Cox RA, Pope RM (1987) Serum-mediated suppression of lymphocyte transformation responses in coccidioidomycosis. Infect Immun 55:1058–1062

    PubMed  CAS  Google Scholar 

  • Cox RA, Vivas JR (1977) Spectrum of in vivo and in vitro cell-mediated immune responses in coccidioidomycosis. Cell Immunol 31:130–141

    PubMed  CAS  Google Scholar 

  • Cox RA, Kennel W, Boncyk L, Murphy JW (1988) Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis. Infect Immun 56:13–17

    PubMed  CAS  Google Scholar 

  • Cox RA, Magee DM, Alaniz R (1994) Role of interferon-gamma in resistance to Coccidioides immitis (submitted)

    Google Scholar 

  • Deepe GS Jr (1988) Protective immunity in murine histoplasmosis: functional comparison of adoptively transferred T-cell clones and splenic T cells. Infect Immun 56:2350–2355

    PubMed  Google Scholar 

  • de Repentigny L, Phaneuf M, Mathieu LG (1992) Gastrointestinal colonization and systemic dissemination of Candida albicans and Candida tropicalis in intact and immunocompromised mice. Infect Immun 60:4907–4914

    PubMed  Google Scholar 

  • Diamond RD, Bennett JE (1973) Disseminated cryptococcosis in man: decreases lymphocyte transformation in response to Cryptococcus neoformans. J Infect Dis 127:694–697

    PubMed  CAS  Google Scholar 

  • Diamond RD, Lyman CA, Wysong DR (1991) Disparate effects of interferon-γ and tumor necrosis factor-a on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro. J Clin Invest 87:711–720

    PubMed  CAS  Google Scholar 

  • Djeu JY (1992) Cytokines and anti-fungal immunity. Adv Exp Med Biol 319:217–223

    PubMed  CAS  Google Scholar 

  • Djeu JY, Blanchard DK, Halkias D, Friedman H (1986) Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-γ and tumor necrosis factor. J Immunol 137:2980–2984

    PubMed  CAS  Google Scholar 

  • Djeu JY, Liu JH, Wei S, Rui H, Pearson CA, Leonard WJ, Blanchard DK (1993) Function associated with IL-2 receptor-β on human neutrophils. J Immunol 150: 960–970

    PubMed  CAS  Google Scholar 

  • Domer J, Garner R, Befidi-Mengue R (1989) Mannan as an antigen in cell-mediated immune (CMI) assays and as a modulator of mannan-specific CMI. Infect Immun 57:693–700

    PubMed  CAS  Google Scholar 

  • Domer JE (1988) Intragastric colonization of infant mice with Candida albicans induces systemic immunity demonstrable upon challenge as adults. J Infect Dis 157: 950–958

    PubMed  CAS  Google Scholar 

  • Domer JE, Carrow EW (1989) Candidiasis. In: Cox RA (ed) Immunology of the fungal diseases. CRC Press, Boca Raton, pp 57–92

    Google Scholar 

  • Domer JE, Lehrer RI (1993) Introduction to Candida: systemic candidiasis. In: Murphy JW, Friedman H, Bendinelli M (eds) Fungal infections and immune responses. Plenum Press, New York, pp 49–116

    Google Scholar 

  • Drutz D, Catanzaro A (1978) Coccidioidomycosis. I. State of the art. Am Rev Respir Dis 117:559–585

    PubMed  CAS  Google Scholar 

  • Dunn PL, North RJ (1991) Early gamma interferon production by natural killer cells is important in defense against murine listeriosis. Infect Immun 59:2892–2900

    PubMed  CAS  Google Scholar 

  • Edwards LB, Acquavira FA, Livesay VT, Cross FW, Palmer CE (1969) An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States. Am Rev Respir Dis 99:1–132

    PubMed  Google Scholar 

  • Ekenna O, Sherertz RJ (1987) Factors affecting colonization and dissemination of Candida albicans from the gastrointestinal tract of mice. Infect Immun 55:1558–1563

    PubMed  CAS  Google Scholar 

  • Fidel PL Jr, Murphy JW (1989) Effects of cyclosporin A on the cells responsible for the anticryptococcal cell-mediated immune response and its regulation. Infect Immun 57:1158–1164

    PubMed  CAS  Google Scholar 

  • Fidel PL Jr, Murphy JW (1990) Characterization of a cell population which amplifies the anticryptococcal delayed-type hypersensitivity response. Infect Immun 58:393–398

    PubMed  Google Scholar 

  • Fidel PL Jr, Sobel JD (1994) The role of cell-mediated immunity in candidasis. Trends Microbiol 2:202–206

    PubMed  Google Scholar 

  • Fidel PL Jr, Lynch ME, Sobel JD (1993) Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun 61: 1990–1995

    PubMed  CAS  Google Scholar 

  • Fidel PL Jr, Lynch ME, Sobel JD (1994) Candida-specific Thl-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun 61:4202–4207

    Google Scholar 

  • Fischer A, Ballet JJ, Griscelli C (1978) Specific inhibition of in vitro Candida-induced lymphocyte proliferation by polysaccharidic antigens present in the serum of patients with chronic mucocutaneous candidiasis. J Clin Invest 62:1005–1013

    PubMed  CAS  Google Scholar 

  • Fitch FW, McKisic MD, Lancki DW, Gajewski TF (1993) Differential regulation of murine T lymphocyte subsets. Annu Rev Immunol 11:29–48

    PubMed  CAS  Google Scholar 

  • Fleischman J, Wu-Hsieh B, Howard DH (1990) The intracellular fate of Histoplasma capsulatum in human macrophages is unaffected by recombinant human interferon-γ. J Infect Dis 161:143–145

    Google Scholar 

  • Flesch IE, Schwamberger G, Kaufmann SH (1989) Fungicidal activity of IFN-y-activated macrophages. Extracellular killing of Cryptococcus neoformans. J Immunol 142:3219–3224

    PubMed  CAS  Google Scholar 

  • Flesch IEA, Kaufmann SHE (1990) Activation of tuberculostatic macrophage function by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 58:2675–2677

    PubMed  CAS  Google Scholar 

  • Flynn NM, Hoeprich PD, Kawachi MM, Lee KK, Lawrence RM, Goldstein E, Jordan GW, Kundargi RS, Wong GA (1979) An unusual outbreak of wind-borne coccidioidomycosis. N Engl J Med 301:358–361

    PubMed  CAS  Google Scholar 

  • Fung PY, Murphy JW (1982) In vitro interactions of immune lymphocytes and Cryptococcus neoformans. Infect Immun 36:1128–1138

    PubMed  CAS  Google Scholar 

  • Garner RE, Childress AM, Human LG, Domer JE (1990) Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells. Infect Immun 588:2613–2620

    Google Scholar 

  • Gifford MA, Buss WC, Douds RJ (1937) Data on Coccidioides fungus infection, Kern County, 1901–1936. Kern County Health Department, California, Annual Report 39–54

    Google Scholar 

  • Gomez AM, Bullock WE, Taylor CL, Deepe GS Jr (1988) Role of L3T4+ T cells in host defense against Histoplasma capsulatum. Infect Immun 56:229–235

    Google Scholar 

  • Gomez AM, Rhodes JC, Deepe GS Jr (1991a) Antigenicity and immunogenicity of an extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infect Immun 59:330–336

    PubMed  CAS  Google Scholar 

  • Gomez FJ, Gomez AM, Deepe GS Jr (1991b) Protection efficacy of a 62 kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infect Immun 59:4459–4464

    PubMed  CAS  Google Scholar 

  • Gordon MA, Vedder DK (1966) Serologic tests in diagnosis and prognosis of cryptococcosis. J Am Med Assoc 197:961–967

    CAS  Google Scholar 

  • Granger DL, Perfect JR, Durack DT (1986) Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. J Immunol 136: 672–680

    PubMed  CAS  Google Scholar 

  • Graybill JR, Alford RH (1974) Cell-mediated immunity in cryptococcosis. Cell Immunol 14:12–21

    PubMed  CAS  Google Scholar 

  • Graybill JR, Drutz DJ (1978) Host defense in cryptococcosis in the nude mouse. Cell Immunol 40:263–274

    PubMed  CAS  Google Scholar 

  • Graybill JR, Mitchell L, Drutz DJ (1979) Host defense in cryptococcosis. III. Protection of nude mice by thymus transplantation. J Infect Dis 140:546–552

    PubMed  CAS  Google Scholar 

  • Green DR, Webb DR (1993) Saying the “S” word in public. Immunol Today 14:523–525

    PubMed  CAS  Google Scholar 

  • Greenfield RA (1992) Host defense system interactions with Candida. J Med Vet Mycol 30:89–104

    PubMed  CAS  Google Scholar 

  • Harvey RP, Stevens DA (1981) In vitro assays of cellular immunity in progressive coccidioidomycosis. Evaluation of suppression with parasitic-phase antigens. Am Rev Respir Dis 23:665–669

    Google Scholar 

  • Henderson HM, Deepe GS Jr (1992) Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones. J Leukoc Biol 51:432–436

    PubMed  CAS  Google Scholar 

  • Hidore MR, Murphy JW (1986) Natural cellular resistance of beige mice against Cryptococcus neoformans. J Immunol 137:3624–3631

    PubMed  CAS  Google Scholar 

  • Hidore MR, Nabavi N, Reynolds CW, Henkart PA, Murphy JW (1990) Cytoplasmic components of natural killer cells limit the growth of Cryptococcus neoformans. J Leukoc Biol 48:15–26

    PubMed  CAS  Google Scholar 

  • Hidore MR, Nabavi N, Sonleitner F, Murphy JW (1991) Murine natural killer cells are fungicidal to Cryptococcus neoformans. Infect Immun 5:1747–1754

    Google Scholar 

  • Hill JO (1992) CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract. J Exp Med 175:1685–1695

    PubMed  CAS  Google Scholar 

  • Hill JO, Aguirre KM (1994) CD4+ T cell-dependent acquired state of immunity that protects the brain against Cryptococcus neoformans. J Immunol 152:2344–2350

    PubMed  CAS  Google Scholar 

  • Hill JO, Harmsen AG (1991) Intrapulmonary growth the dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD44- or CD8+ T-cells. J Exp Med 173:775–758

    Google Scholar 

  • Hoy JF, Murphy JW, Miller GPG (1989) T cell response to soluble cryptococcal antigens after recovery from cry-ptococcal infection. J Infect Dis 159:116–119

    PubMed  CAS  Google Scholar 

  • Huffnagle GB, Yates JL, Lipscomb MF (1991a) Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells. J Exp Med 173:793–800

    PubMed  CAS  Google Scholar 

  • Huffnagle GB, Yates JL, Lipscomb MF (1991b) T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect Immun 59:1423–1433

    PubMed  CAS  Google Scholar 

  • Huffnagle GB, Lipscomb MF, Lovchik JA, Hoag KA, Street NE (1994) The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol 55:35–42

    PubMed  CAS  Google Scholar 

  • Imam N, Carpenter CCJ, Mayer KH, Fisher A, Stein M, Danforth SB (1990) Hierarchical pattern of mucosal Candida infections in HIV-seropositive women. Am J Med 89:142–146

    PubMed  CAS  Google Scholar 

  • Jenkins MK, Taylor PS, Norton SD, Urdahl KB (1991) CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production in human T cells. J Immunol 147:2461–2466

    PubMed  CAS  Google Scholar 

  • Jensen J, Warner T, Balish E (1993) Resistance of SCID mice to Candida albicans administered intravenously or colonizing the gut: role of polymorphonuclear leukocytes and macrophages. J Infect Dis 167:912–919

    PubMed  CAS  Google Scholar 

  • Johnson JG, Jenkins MK (1994) Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J Immunol 152:429–437

    PubMed  CAS  Google Scholar 

  • Johnson WM (1982) Racial factors in coccidioidomycosis: mortality experience in Arizona. Ariz Med 39:18–24

    PubMed  CAS  Google Scholar 

  • June CH, Ledbetter JA, Gillespie MM, Lindsten T, Thompson CB (1987) T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin-2 gene expression. Mol Cell Biol 7:4472–4481

    PubMed  CAS  Google Scholar 

  • Kagaya K, Shinoda T, Fukazawa Y (1981) Murine defense mechanisms against Candida albicans infection. I. Collaboration of cell-mediated and humoral immunities in protection against systemic C. albicans infection. Microbiol Immunol 25:647–654

    PubMed  CAS  Google Scholar 

  • Khakpour FR, Murphy JW (1987) Characterization of a third-order suppressor T cell (Ts3) induced by crypto-coccal antigen(s). Infect Immun 55:1657–1662

    PubMed  CAS  Google Scholar 

  • Kirkland TN, Fierer J (1983) Inbred mouse strains differ in resistance to lethal Coccidioides immitis infection. Infect Immun 40:912–916

    PubMed  CAS  Google Scholar 

  • Kirkland TN, Fierer J (1985) Genetic control of resistance to Coccidioides immitis: a single gene that is expressed in the spleen cells determines resistance. J Immunol 135:548–552

    PubMed  CAS  Google Scholar 

  • Kirkpatrick CH (1989) Chronic mucocutaneous candidiasis. Eur J Clin Microbiol Infect Dis 8:448–456

    PubMed  CAS  Google Scholar 

  • Kirkpatrick CH, Smith TK (1974) Chronic mucocutaneous candidiasis: immunologic and antibiotic therapy. Ann Intern Med 80:310–320

    PubMed  CAS  Google Scholar 

  • Klein RS, Harris CA, Small CB, Moll B, Lesser M, Friedland GH (1984) Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 311:354–358

    PubMed  CAS  Google Scholar 

  • Kong YM, Levine HB (1967) Experimentally induced immunity in the mycoses. Bacteriol Rev 31:35–53

    PubMed  CAS  Google Scholar 

  • Kong YM, Levine HT, Smith CE (1963) Immunogenic properties of non-disrupted and disrupted spherules of Coccidioides immitis in mice. Sabouraudia 2:131–142

    PubMed  CAS  Google Scholar 

  • Lane TE, Wu-Hsieh BA, Howard DH (1991) Iron limitation and gamma interferon-mediated antihistoplasmal state of murine macrophages. Infect Immun 59: 2274–2278

    PubMed  CAS  Google Scholar 

  • Lane TE, Wu-Hsieh BA, Howard DH (1993) Gamma interferon cooperates with lipopolysaccharide to activate mouse splenic macrophages to an antihistoplasmal state. Infect Immun 61:1468–1473

    PubMed  CAS  Google Scholar 

  • Lecara G, Cox RA, Simpson RB (1983) Coccidioides immitis vaccine: potential of an alkali-soluble, water-soluble cell wall antigen. Infect Immun 39:473–475

    PubMed  CAS  Google Scholar 

  • Levine HB, Cobb JM, Smith CE (1960) Immunity to coccidioidomycosis induced in mice by purified spherule, arthrospore, and mycelial vaccines. Trans NY Acad Sci 22:436–449

    CAS  Google Scholar 

  • Levine HB, Cobb JM, Smith CE (1961) Immunogenicity of spherule-endospore vaccine of Coccidioides immitis in mice. J Immunol 87:218–227

    PubMed  CAS  Google Scholar 

  • Levine HB, Gonzalez-Ochoa A, Ten-Eyck DR (1973) Dermal sensitivity to Coccidioides immitis. A comparison of responses elicited in man by spherulin and coccidi-oidin. Am Rev Respir Dis 107:379–386

    PubMed  CAS  Google Scholar 

  • Levitz SM (1991a) Activation of human peripheral blood mononuclear cells by interleukin-2 and granulocyte-macrophage colony-stimulating factor to inhibit Cryptococcus neoformans. Infect Immun 59:3393–3397

    PubMed  CAS  Google Scholar 

  • Levitz SM (1991b) The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis. Rev Infect Dis 13:1163–1169

    PubMed  CAS  Google Scholar 

  • Levitz SM, Dupont MP (1993) Phenotypic and functional characterization of human lymphocytes activated by interleukin-2 to directly inhibit growth of Cryptococcus neoformans in vitro. J Clin Invest 91:1490–1498

    PubMed  CAS  Google Scholar 

  • Levitz SM, Farrell TP (1990) Growth inhibition of Cryptococcus neoformans by cultured human monocytes: role of the capsule, opsonins, the culture surface, and cytokines. Infect immun 58:1201–1209

    PubMed  CAS  Google Scholar 

  • Levitz SM, Farrell TP, Maziarz RT (1991) Killing of Cryptococcus neoformans by human peripheral blood mononuclear cells stimulated in culture. J Infect Dis 163:1108–1113

    PubMed  CAS  Google Scholar 

  • Levitz SM, Dupont MP, Smail EH (1994a) Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans. Infect Immun 62:194–202

    PubMed  CAS  Google Scholar 

  • Levitz SM, Tabuni A, Kornfeld H, Reardon CC, Golenbock DT (1994b) Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans. Infect Immun 62:1975–1981

    PubMed  CAS  Google Scholar 

  • Lim TS, Murphy JW (1980) Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice. Infect Immun 30:5–11

    PubMed  CAS  Google Scholar 

  • Lim TS, Murphy JW, Cauley LK (1980) Host-etiological agent interactions in intranasally and intraperitoneally induced cryptococcosis in mice. Infect Immun 29: 633–641

    PubMed  CAS  Google Scholar 

  • Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174: 561–569

    PubMed  CAS  Google Scholar 

  • Mahanty S, Greenfield RA, Joyce WA, Kincade PW (1988) Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun 56:3162–3166

    PubMed  CAS  Google Scholar 

  • Marmor MF, Barnett EV (1968) Cutaneous anergy without systemic disease. A syndrome associated with mucocutaneous fungal infection. Am J Med 44:979–989

    PubMed  CAS  Google Scholar 

  • Masur H, Ognibene FP, Yarchoan R, Shelhamer JH, Baird BF, Travis W, Suffredini AF, Deyton L, Kovacs JA, Falloon J, Davey R, Polis M, Metcalf J, Baseler M, Wesley R, Gill VJ, Fauci AS, Lane HC (1989) CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. Ann Intern Med 111:223–231

    PubMed  CAS  Google Scholar 

  • Meyer RD, Holmberg K (1989) Fungal infections in HIV-infected patients. In: Holmberg K, Meyer RD (eds) Diagnosis and therapy of systemic fungal infections. Raven Press, New York

    Google Scholar 

  • Michie CA, McLean A, Alcock C, Beverley PCL (1992) Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360:264–265

    PubMed  CAS  Google Scholar 

  • Miller GPG, Lewis DE (1987) In vitro effect of cyclo-sporine on interleukin-2 receptor expression stimulated by Cryptococcus neoformans. J Infect Dis 155:799–802

    PubMed  CAS  Google Scholar 

  • Miller GPG, Puck J (1984) In vitro human lymphocyte responses to Cryptococcus neoformans. Evidence for primary and secondary responses in normal and infected subjects. J Immunol 133:166–172

    PubMed  CAS  Google Scholar 

  • Modlin RL, Segal GP, Hofmann FM, Walley MS, Johnson RH, Taylor CR, Res TH (1985) In situ localization of T lymphocytes in disseminated coccidioidomycosis. J Infect Dis 151:314–319

    PubMed  CAS  Google Scholar 

  • Mody CH, Lipscomb MF, Street NE, Toews GB (1990) Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J Immunol 144:1472–1477

    PubMed  CAS  Google Scholar 

  • Mody CH, Tyler CL, Sitrin RG, Jackson C, Toews GB (1991) Interferon-gamma activates rat alveolar macrophages for anticryptococcal activity. Am J Resp Cell Mol Biol 5:19–26

    CAS  Google Scholar 

  • Mody CH, Chen G, Jackson C, Curtis JL, Toews GB (1993) Depletion of murine CD8+ T cells in vivo decreases pulmonary clearance of a moderately virulent strain of Cryptococcus neoformans. J Lab Clin Med 121:765–773

    PubMed  CAS  Google Scholar 

  • Mody CH, Paine R III, Jackson C, Chen GH, Toews GB (1994) CD8 cells play a critical role in delayed type hypersensitivity to intact Cryptococcus neoformans. J Immunol 152:3970–3979

    PubMed  CAS  Google Scholar 

  • Monoz AI, Limbert D (1977) Skin reactivity to Candida and streptokinase-streptodornase antigens in normal pediatric subjects: influence of age and acute illness. J Pediatr 91:565–568

    Google Scholar 

  • Morgan MA, Blackstock R, Bulmer GS, Hall NK (1983) Modification of macrophage phagocytosis in murine cryptococcosis. Infect Immun 40:493–500

    PubMed  CAS  Google Scholar 

  • Moser SA, Lyon FL, Domer JE, Williams JE (1982) Immunization of mice by intracutaneous inoculation with viable virulent Cryptococcus neoformans: immunological and histopathological parameters. Infect Immun 35:685–696

    PubMed  CAS  Google Scholar 

  • Mosley RL, Murphy JW, Cox RA (1986) Immunoadsorption of Cryptococcus-specific suppressor T-cell factors. Infect Immun 51:844–850

    PubMed  CAS  Google Scholar 

  • Mosmann TR, Coffman RL (1989a) Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 46:111–147

    PubMed  CAS  Google Scholar 

  • Mosmann TR, Coffman RL (1989b) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173

    PubMed  CAS  Google Scholar 

  • Muchmore HG, Felton FG, Salvin SB, Rhoades ER (1969) Delayed hypersensitivity to cryptococcin in man. Sabouraudia 6:285–288

    Google Scholar 

  • Mueller DL, Jenkins M, Schwartz RH (1989) Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7:445–480

    PubMed  CAS  Google Scholar 

  • Murphy JW (1985) Effects of first-order Cryptococcus-specific T-suppressor cells on induction of cells responsible for delayed-type hypersensitivity. Infect Immun 48:439–445

    PubMed  CAS  Google Scholar 

  • Murphy JW (1988) Influence of cryptococcal antigens on cell-mediated immunity (CMI). Rev Infect Dis 10:5432–5435

    Google Scholar 

  • Murphy JW (1989a) Cryptococcosis. In: Cox RA (ed) Immunology of the fungal diseases. CRC Press, Boca Raton, pp 93–138

    Google Scholar 

  • Murphy JW (1989b) Immunoregulation in cryptococcosis. In: Kurstak E (ed) Immunology of fungal diseases. Marcel Dekker, New York, pp 319–345

    Google Scholar 

  • Murphy JW (1989c) Natural host resistance mechanisms against systemic mycotic agents. In: Reynolds CW, Wiltrout RH (eds) Functions of the natural immune system. Plenum, New York, pp 149–184

    Google Scholar 

  • Murphy JW (1993) Cytokine profiles associated with induction of the anticryptococcal cell-mediated immune response. Infect Immun 61:4750–4759

    PubMed  CAS  Google Scholar 

  • Murphy JW, Cox RA (1988) Induction of antigen-specific suppression by circulating Cryptococcus neoformans antigen. Clin Exp Immunol 73:174–180

    PubMed  CAS  Google Scholar 

  • Murphy JW, McDaniel DO (1982) In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans. J Immunol 128:1577–1583

    PubMed  CAS  Google Scholar 

  • Murphy JW, Moorhead JW (1982) Regulation of cell-mediated immunity in cryptococcosis. I. Induction of specific afferent T suppressor cells by cryptococcal antigen. J Immunol 128:276–283

    PubMed  CAS  Google Scholar 

  • Murphy JW, Mosley RL (1985) Regulation of cell-mediated immunity in cryptococcosis. III. Characterization of second-order T suppressor cells (Ts2). J Immunol 134:577–584

    PubMed  CAS  Google Scholar 

  • Murphy JW, Pahlavan N (1979) Cryptococcal culture filtrate antigen for detection of delayed-type hypersensitivity in cryptococcosis. Infect Immun 25:284–292

    PubMed  CAS  Google Scholar 

  • Murphy JW, Gregory JA, Larsh HW (1974) Skin testing of guinea pigs and footpad testing of mice with a new antigen for detecting delayed hypersensitivity to Cryptococcus neoformans Infect Immun 9:404–409

    PubMed  CAS  Google Scholar 

  • Murphy JW, Mosley RL, Moorhead JW (1983) Regulation of cell-mediated immunity in cryptococcosis. II. Characterization of first-order T suppressor cells (Tsl) and induction of second-order suppressor cell. J Immunol 130:2876–2881

    PubMed  CAS  Google Scholar 

  • Murphy JW, Mosley RL, Cherniak R, Reyes GH, Kozel TR, Reiss E (1988) Serological, electrophoretic, and biological properties of Cryptococcus neoformans antigens. Infect Immun 56:424–431

    PubMed  CAS  Google Scholar 

  • Murphy JW, Hidore MR, Wong SC (1993) Direct interactions of human lymphocytes with the yeast-like organism, Cryptococcus neoformans. J Clin Invest 91: 1553–1566

    PubMed  CAS  Google Scholar 

  • Murphy JW, Wu-Hsieh B, Singer-Vermes LM, Ferrante A, Moser S, Russo M, Vaz CAC, Burger E, Calich VLG, Kowanko IC, Rathjen DA, Martin AJ, Buey RP, Chen Q (1994) Cytokines in the host response to mycotic agents. J Med Vet Mycol 32:S1 123–131

    PubMed  Google Scholar 

  • Narayanan R, Joyce WA, Greenfield RA (1991) Gastrointestinal candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun 59:2116–2119

    PubMed  CAS  Google Scholar 

  • Nelson RD, Herron MJ, McCormack RT, Gehrz GC (1984) Two mechanisms of inhibition of human lymphocyte proliferation by soluble yeast mannan polysaccharide. Infect Immun 43:1041–1046

    PubMed  CAS  Google Scholar 

  • Nelson RD, Shibata N, Podzorski RP, Herron MJ (1991) Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action. Clin Microbiol Rev 4:1–19

    PubMed  CAS  Google Scholar 

  • Newman SL, Gootee L (1992) Colony-stimulating factors activate human macrophages to inhibit intracellular growth of Histoplasma capsulatum yeasts. Infect Immun 60:4593–4597

    PubMed  CAS  Google Scholar 

  • Newman SL, Bucher C, Rhodes JC, Bullock WE (1990) Phagocytosis of Histoplasma capsulatum yeasts and microconidia by human cultured macrophages and alveolar macrophages. Cellular cytoskeleton requirement for attachment and ingestion. J Clin Invest 85: 223–230

    PubMed  CAS  Google Scholar 

  • Nickerson DA, Havens RA, Bullock WE (1981) Immuno-regulation in disseminated histoplasmosis. Characterization of splenic suppressor cells. Cell Immunol 60:287–297

    PubMed  CAS  Google Scholar 

  • Nishimura K, Miyaji M (1979) Histopathological studies on experimental cryptococcosis in nude mice. Myco-pathology 68:145–153

    CAS  Google Scholar 

  • Nykjaer A, Moller B, Todd II RF, Christensen T, Andreasen PA, Gliemann J, Petersen CM (1994) Urokinase receptor an activation antigen in human T lymphocytes. J Immunol 152:505–516

    PubMed  CAS  Google Scholar 

  • Odds FC (1979) Candida and candidosis. Leicester University Press, Leicester

    Google Scholar 

  • Opelz G, Scheer MI (1975) Cutaneous sensitivity and in vitro responsiveness of lymphocytes in patients with disseminated coccidioidomycosis. J Infect Dis 132: 250–255

    PubMed  CAS  Google Scholar 

  • Oppenheim JJ, Zachariae COC, Mukaida N, Matsushima K (1991) Properties of the novel proinflammatory supergene “intercrine” cytokine family. Annu Rev Immunol 9:617–648

    PubMed  CAS  Google Scholar 

  • Pappagianis D (1980) Epidemiology of coccidioidomycosis. In: Stevens DA (ed) Coccidioidomycosis. Plenum Press, New York, pp 63–85

    Google Scholar 

  • Pappagianis D, Hector R, Levine HB, Collins MS (1979) Immunization of mice against coccidioidomycosis with a subcellular vaccine. Infect Immun 25:440–445

    PubMed  CAS  Google Scholar 

  • Paterson PY, Semo R, Blumenschein G, Swelstad J (1971) Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy. Clin Exp Immunol 9:595–602

    PubMed  CAS  Google Scholar 

  • Pereira HA, Shafer WM, Pohl J, Martin LE, Spitznagel JK (1990) CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J Clin Invest 85:1468–1476

    PubMed  CAS  Google Scholar 

  • Perfect JR, Granger DL, Durack DT (1987) Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. J Infect Dis 156:316–323

    PubMed  CAS  Google Scholar 

  • Petkus AF, Baum LL (1987) Natural killer cell inhibition of young spherules and endospores of Coccidioides immitis. J Immunol 139:3107–3111

    PubMed  CAS  Google Scholar 

  • Podzorski RP, Nelson RD (1989) Pathogenesis of candidiasis: immunosuppression by cell wall mannan catabolites. Arch Surg 124:1290–1294

    PubMed  CAS  Google Scholar 

  • Podzorski RP, Gray GR, Nelson RD (1990) Different effects of native Candida albicans mannan and mannanderived oligosaccharides on antigen-stimulated lymphoproliferation in vitro. J Immunol 144:707–716

    PubMed  CAS  Google Scholar 

  • Pope LM, Cole GT, Guentzel MN, Berry LJ (1979) Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge. Infect Immun 25:702–707

    PubMed  CAS  Google Scholar 

  • Postlethwaite AE, Jackson BK, Beachy EH, Kang AH (1982) Formation of multinucleated giant cells from human monocyte precursors. Mediation by a soluble protein from antigen- and mitogen-stimulated lymphocytes. J Exp Med 155:168–178

    PubMed  CAS  Google Scholar 

  • Puccetti P, Mencacci A, Cenci E, Spaccapelo R, Mosci P, Enssle K, Romani L, Bistoni F (1994) Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J Infect Dis 169:1325–1331

    PubMed  CAS  Google Scholar 

  • Qian Q, Jutila MA, Rooijen NV, Cutler JE (1994) Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J Immunol 152:5000–5008

    PubMed  CAS  Google Scholar 

  • Robinson BE, Hall NK, Bulmer GS, Blackstock R (1982) Suppression of responses to cryptococcal antigen in murine cryptococcosis. Mycopathologia 80:157–163

    PubMed  CAS  Google Scholar 

  • Romani L, Mocci S, Bietta C, Lanfaloni L, Pucetti P, Bistoni F (1991) Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Thl responses with acquired resistance. Infect Immun 59:4647–4654

    PubMed  CAS  Google Scholar 

  • Romani L, Mencacci A, Cenci E, Mosci P, Vitellozzi G, Grohmann U, Puccetti P, Bistoni F (1992a) Course of primary candidiasis in T cell-depleted mice infected with attenuated variant cells. J Infect Dis 166:1384–1392

    PubMed  CAS  Google Scholar 

  • Romani L, Mencacci A, Grohmann U, Mocci S, Mosci P, Puccetti P (1992b) Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med 176:19–25

    PubMed  CAS  Google Scholar 

  • Romani L, Mencacci A, Cenci E, Spaccapelo R, Mosci P, Puccetti P, Bistoni F (1993a) CD4+ subset expression in murine candidiasis. The responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J Immunol 150:925–931

    PubMed  CAS  Google Scholar 

  • Romani L, Mencacci A, Cenci E, Spaccapelo R, Schiaffella E, Tonnetti L, Puccetti P, Bistoni F (1993b) Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice. Infect Immun 61:3769–3774

    PubMed  CAS  Google Scholar 

  • Romani L, Puccetti P, Mencacci A, Cenci ES R, Tonnetti L, Grohmann U, Bistoni F (1994) Neutralization of ILIO up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol 152:3514–3521

    PubMed  CAS  Google Scholar 

  • Salkowski C, Balish E (1990) Pathogenesis of Cryptococcus neoformans in congenitaly immunodeficient beige athymic mice. Infect Immun 58:3300–3306

    PubMed  CAS  Google Scholar 

  • Salkowski C, Balish E (1991) A monoclonal antibody to gamma interferon blocks augmentation of natural killer cell activity induced during systemic cryptococcosis. Infect Immun 59:486–493

    PubMed  CAS  Google Scholar 

  • Salvin SB, Smith RF (1961) An antigen for detection of hypersensitivity to Cryptococcus neoformans. Proc Soc Exp Biol Med 108:498–501

    PubMed  CAS  Google Scholar 

  • Samonis G, Anaissie EJ, Rosenbaum B, Bodey GP (1990) A model of sustained gastrointestinal colonization of Candida albicans in healthy adult mice. Infect Immun 58:1514–1517

    PubMed  CAS  Google Scholar 

  • Scheer M, Opelz G, Terasaki P, Hewett W (1973) The association of disseminated coccidioidomycosis and histocompatibility type. 13th Interscience Conf on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, DC, Abstr 157

    Google Scholar 

  • Schimpff SC, Bennett JE (1975) Abnormalities in cell-mediated immunity in patients with Cryptococcus neoformans infection. J Allergy Clin Immunol 55:430–441

    PubMed  CAS  Google Scholar 

  • Shannon DC, Johnson G, Rosen FS, Austen KF (1966) Cellular reactivity to Candida albicans antigen. New Engl J Med 275:690–693

    PubMed  CAS  Google Scholar 

  • Sher A, Coffman RL (1992) Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 10:385–409

    PubMed  CAS  Google Scholar 

  • Sigal NH, Dumonat FJ (1992) Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol 10:519–560

    PubMed  CAS  Google Scholar 

  • Slagle DC, Cox RA, Kuruganti U (1989) Induction of tumor necrosis factor alpha by spherules of Coccidioides immitis. Infect Immun 57:1916–1921

    PubMed  CAS  Google Scholar 

  • Smith CE, Whiting EG, Baker EE, Rosenberger HG, Beard RR, Saito MT (1948) The use of coccidioidin. Am Rev Tuberc 57:330–360

    PubMed  CAS  Google Scholar 

  • Smith JG, Magee DM, Williams DM, Graybill JR (1990) Tumor necrosis factor-α plays a role in host defense against Histoplasma capsulatum. J Infect Dis 162: 1349–1353

    PubMed  CAS  Google Scholar 

  • Smith PD, Lamerson CL, Banks SM, Saini SS, Wahl LM, Calderone RA, Wahl SM (1990) Granulocyte-macrophage colony-stimulating factor augments human monocyte fungicidal activity of Candida albicans. J Infect Dis 161:999–1005

    PubMed  CAS  Google Scholar 

  • Spencer PM, Jackson GG (1989) Fungal and mycobacterial infections in patients infected with the human immunodeficiency virus. J Antimicrob Chemother 23(Suppl A): 107–125

    PubMed  Google Scholar 

  • Stobo JD, Paul S, Van Scoy RE, Hermans PE (1976) Suppressor thymus-derived lymphocytes in fungal infections. J Clin Invest 57:319–328

    PubMed  CAS  Google Scholar 

  • Tavitian A, Raufman JP, Rosenthal LE (1986) Oral candidiasis as a marker for esophageal candidiasis in the acquired immunodeficiency syndrome. Ann Intern Med 104:354–358

    Google Scholar 

  • Trinchieri G (1989) Biology of natural killer cells. Adv Immunol 47:187–376

    PubMed  CAS  Google Scholar 

  • Trinchieri G (1993) Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 14:335–338

    PubMed  CAS  Google Scholar 

  • Valdimarsson H, Higgs JM, Wells RS, Yamamura M, Hobbs JR, Holt PJL (1973) Immune abnormalities associated with chronic mucocutaneous candidiasis. Cell Immunol 6:348–361

    PubMed  CAS  Google Scholar 

  • Vecchiarelli A, Cenci E, Marconi P, Rossi R, Riccardi C, Bistoni F (1989a) Immunosuppressive effect of cyclosporin A on resistance to systemic infection with Candida albicans. J Med Microbiol 30:183–192

    PubMed  CAS  Google Scholar 

  • Vecchiarelli A, Cenci E, Puliti M, Blasi E, Puccetti P, Cassone A, Bistoni F (1989b) Protective immunity induced by low-virulence Candida albicans: cytokine production in the development of the anti-infectious state. Cell Immunol 124:334–344

    PubMed  CAS  Google Scholar 

  • Wang M, Friedman H, Djeu JY (1989) Enhancement of human monocyte function against Candida albicans by the colony-stimulating factors (CSF): IL-3, granulocyte-macrophage-CSF, and macrophage-CSF. J Immunol 143:671–677

    PubMed  CAS  Google Scholar 

  • Williams DM, Graybill JR, Drutz DJ (1981) Adoptive transfer of immunity to Histoplasma capsulatum in athymic nude mice. Sabouraudia 19:39–48

    PubMed  CAS  Google Scholar 

  • Williams PL, Sable DL, Sorgen SP, Pappagianis D, Levine HB, Brodine SK, Brown BW, Grumet FC, Stevens DA (1984) Immunologic responsiveness and safety associated with the Coccidioides immitis spherule vaccine in volunteers of white, black, and Filipino ancestry. Am J Epidemiol 119:591–602

    PubMed  CAS  Google Scholar 

  • Wilson BD, Sohnle PG (1986) Participation of neutrophils and delayed hypersensitivity in the clearance of experimental cutaneous candidiasis in mice. Am J Pathol 123:241–249

    PubMed  CAS  Google Scholar 

  • Wu-Hsieh B (1989) Relative susceptibilities of inbred mouse strains C57BL/6 and A/J to infection with Histoplasma capsulatum. Infect Immun 57:3788–3792

    PubMed  CAS  Google Scholar 

  • Wu-Hsieh B, Howard DH (1993) Histoplasmosis. In: Murphy JW, Friedman H, Bendinelli M (eds) Fungal infections and immune responses. Plenum Press, New York, pp 213–250

    Google Scholar 

  • Wu-Hsieh B, Lee GL, Franco M, Hofman FM (1992) Early activation of splenic macrophages by tumor necrosis factor alpha is important in determining the outcome of experimental histoplasmosis. Infect Immun 60:4230–4238

    PubMed  CAS  Google Scholar 

  • Wu-Hsieh BA, Howard DH (1984) Inhibition of growth of Histoplasma capsulatum by lymphokine-stimulated macrophages. J Immunol 132:2593–2597

    PubMed  CAS  Google Scholar 

  • Wu-Hsieh BA, Howard DH (1987) Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon. Infect Immun 55: 1014–1026

    PubMed  CAS  Google Scholar 

  • Wu-Hsieh BA, Howard DH (1992) Intracellular growth inhibition of Histoplasma capsulatum induced in murine macrophages by recombinant gamma interferon is not due to limitation of the supply of methionine or cysteine to the fungus. Infect Immun 60:698–700

    PubMed  CAS  Google Scholar 

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  1. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK, 73190, USA

    Juneann W. Murphy

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  1. Department of Microbiology and Immunology - 43-239 CHS, UCLA School of Medicine, Los Angeles, CA, 90024, USA

    Dexter H. Howard

  2. Plant Research Center, Mycotoxin Programme, Agriculture Canada, Ottawa, Ontario, K1A 0C6, Canada

    J. David Miller

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Murphy, J.W. (1996). Cell-Mediated Immunity. In: Howard, D.H., Miller, J.D. (eds) Human and Animal Relationships. The Mycota, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10373-9_3

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