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Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles pp 191–206Cite as

The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity

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Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Summary

Glial fibrillary acidic protein (GFAP), an intermediate filament of astrocytes, shows progressive increases per cell during normal aging in the absence of neurodegenerative diseases. Increased transcription mediates the increase of GFAP expression. We hypothesize that increased GFAP expression is a factor in age-related impairments of synaptic plasticity, and we are developing an in vitro model to test this hypothesis.

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Authors
  1. Caleb E. Finch
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  2. Todd E. Morgan
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  3. Irina Rozovsky
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  4. Min Wei
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Editor information

Editors and Affiliations

  1. Service d’Endocrinologie, Hôpital Bicêtre, 78, avenue de Géneral Leclerc, 94275, Kremlin-Bicêtre, France

    Philippe Chanson

  2. Institut National de la Santé et de la Recherche Médicale U549, IFR Broca-Sainte Anne, 2ter rue d’Alésia, 75014, Paris, France

    Jacques Epelbaum

  3. Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands

    Steven Lamberts

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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Finch, C.E., Morgan, T.E., Rozovsky, I., Wei, M. (2004). The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity. In: Chanson, P., Epelbaum, J., Lamberts, S., Christen, Y. (eds) Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07019-2_13

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  • DOI: https://doi.org/10.1007/978-3-662-07019-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07359-5

  • Online ISBN: 978-3-662-07019-2

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