Skip to main content

Involvement of Chromosome 12 in Well-Differentiated Liposarcoma

  • Conference paper
Book cover Chromosome 12 Aberrations in Human Solid Tumors

Abstract

It is well known that “accurate classification of a given tumor is often not easy, so much that acknowledged international experts are still unable to pin a label on about 10% of sarcomas”(Fletcher 1990). In this context, the characterization of new tumor markers is of paramount interest for the diagnosis, prognosis, and classification of soft tissue tumors (Sandberg and Turc-Carel 1987; Molenaar et al. 1989; Fletcher et al. 1991).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willén H, Rydholm A, Mitelman F (1992) Rearrangement of the transcription factor gene CHOP in myxoid liposarcoma with t(12;16)(q13;p11). Genes Chrom Cancer 5:278–285

    Article  PubMed  CAS  Google Scholar 

  • Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W (1987) Rearrangements of chromosome 12q13–q15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet Cell Genet 45:187–190

    Article  PubMed  CAS  Google Scholar 

  • Enzinger FM, Weiss SW (1988) Soft tissue tumors, 2nd edn. Mosby, St Louis

    Google Scholar 

  • Evans HL, Soule EH, Winkelmann RK (1979) Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma. A reappraisal of 30 cases formerly classified as well differentiated liposarcoma. Cancer 43:574–584

    Article  PubMed  CAS  Google Scholar 

  • Fletcher CDM (1990) Introduction. In: Fletcher CDM, McKee PH (eds) Pathobiology of soft tissue tumors. Churchill Livingstone, Edinburgh, pp 1–7

    Google Scholar 

  • Fletcher JA, Kozakewich HP, Hoffer FA, Lage JM, Weidner N, Tepper R, Pinkus GS, Morton CC, Corson JM (1991) Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med 324:436–442

    Article  PubMed  CAS  Google Scholar 

  • Heim S, Nilbert M, Vanni R, Floderus U-M, Mandahl N, Liedgren S, Lecca U, Mitelman F (1988) A specific translocation, t(12;14)(q14–q15;q23–q24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 32:13–17

    Article  PubMed  CAS  Google Scholar 

  • Karakousis CP, Dal Cin P, Turc-Carel C, Limon J, Sandberg AA (1987) Chromosomal changes in soft-tissue sarcomas: a new diagnostic parameter. Arch Surg 122:1257–1260

    Article  PubMed  CAS  Google Scholar 

  • Limon J, Dal Cin P, Sandberg AA (1986) Application of long term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet 23:305–313

    Article  PubMed  CAS  Google Scholar 

  • Mandahl N, Willén H, Rydholm A, Heim S, Mitelman F (1993) Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma. Genes Chrom Cancer 6:121–123

    Article  PubMed  CAS  Google Scholar 

  • Mark J, Sandros J, Wedell B, Stenman G, Ekedahl C (1988) Significance of the choice of tissue culture technique on the chromosomal patterns in human mixed salivary gland tumors. Cancer Genet Cytogenet 33:229–244

    Article  PubMed  CAS  Google Scholar 

  • Molenaar WM, De Jong B, Buist J, Idenburg VJS, Seruca R, Vos AM, Hoekstra HJ (1989) Chromosomal analysis and classification of soft tissue sarcomas. Lab Invest 60:266–274

    PubMed  CAS  Google Scholar 

  • Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80–83

    Article  PubMed  CAS  Google Scholar 

  • Pinkel D, Straume T, Gray JW (1983) Cytogenetic analysis using quantitative, highly sensitive, fluorescence hybridization. Proc Natl Acad Sci USA 83:2934–2938

    Article  Google Scholar 

  • Sandberg AA (1990) The chromosomes in human cancer and leukemia, 2nd edn. Elsevier, New York

    Google Scholar 

  • Sandberg AA, Turc-Carel C (1987) The cytogenetics of solid tumors. Relation to diagnosis, classification and pathology. Cancer 59:387–395

    Article  PubMed  CAS  Google Scholar 

  • Smith SH, Weiss SW, Jankowski SA, Coccia MA, Meltzer PS (1992) SAS amplification in soft tissue sarcoma. Cancer Res 53:3746–3749

    Google Scholar 

  • Sreekantaiah C, Karakousis CP, Leong SPL, Sandberg AA (1992) Cytogenetic findings in liposarcoma correlate with histopathologic subtypes. Cancer 69:2484–2495

    Article  PubMed  CAS  Google Scholar 

  • Stephenson CF, Berger CS, Leong SPL, Davis JR, Sandberg AA (1992) Analysis of a giant marker chromosome in a well-differentiated liposarcoma using cytogenetics and fluorescence in situ hybridization. Cancer Genet Cytogenet 61:134–138

    Article  PubMed  CAS  Google Scholar 

  • Turc-Carel C, Dal Cin P, Boghosian J, Terk-Zakarian J, Sandberg AA (1988) Consistent breakpoints in region 14q22–ql4 in uterine leiomyoma. Cancer Genet Cytogenet 32:25–31

    Article  PubMed  CAS  Google Scholar 

  • Vanni R, Lecca U (1988) Involvement of the long arm of chromosome 12 in chromosome rearrangement of uterine leiomyoma. Cancer Genet Cytogenet 32:33–34

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Pedeutour, F., Lamouroux, A., Coindre, J.M., Collin, F., Huffermann, K., Turc-Carel, C. (1994). Involvement of Chromosome 12 in Well-Differentiated Liposarcoma. In: Bullerdiek, J., Bartnitzke, S. (eds) Chromosome 12 Aberrations in Human Solid Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06255-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-06255-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-06257-9

  • Online ISBN: 978-3-662-06255-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics