Chapter

Phospholipids and Signal Transmission

Volume 70 of the series Nato ASI Series pp 249-256

Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex

  • M. V. RapallinoAffiliated withClinica Neurologica, Università di Genova
  • , A. CupelloAffiliated withClinica Neurologica, Università di Genova
  • , P. MainardiAffiliated withClinica Neurologica, Università di Genova
  • , G. BesioAffiliated withClinica Neurologica, Università di Genova
  • , C. W. LoebAffiliated withClinica Neurologica, Università di Genova

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Abstract

Neurotransmitter postsynaptic receptors, as integral membrane proteins, are located within the phospholipid bilayer of the acceptive membrane. Therefore it appears reasonable that the phospholipid environment of the plasma membrane influences and modulates the functional activity of these receptors. In addition, the phospholipid composition of the two leaflets of the bilayer may introduce a further element able to influence the function of these receptors.