Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex

  • M. V. Rapallino
  • A. Cupello
  • P. Mainardi
  • G. Besio
  • C. W. Loeb
Conference paper

DOI: 10.1007/978-3-662-02922-0_20

Part of the Nato ASI Series book series (NATO ASI, volume 70)
Cite this paper as:
Rapallino M.V., Cupello A., Mainardi P., Besio G., Loeb C.W. (1993) Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex. In: Massarelli R., Horrocks L.A., Kanfer J.N., Löffelholz K. (eds) Phospholipids and Signal Transmission. Nato ASI Series (Series H: Cell Biology), vol 70. Springer, Berlin, Heidelberg

Abstract

Neurotransmitter postsynaptic receptors, as integral membrane proteins, are located within the phospholipid bilayer of the acceptive membrane. Therefore it appears reasonable that the phospholipid environment of the plasma membrane influences and modulates the functional activity of these receptors. In addition, the phospholipid composition of the two leaflets of the bilayer may introduce a further element able to influence the function of these receptors.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. V. Rapallino
    • 1
  • A. Cupello
    • 1
  • P. Mainardi
    • 1
  • G. Besio
    • 1
  • C. W. Loeb
    • 1
  1. 1.Clinica NeurologicaUniversità di GenovaGenovaItaly

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