Direct Effect of Phosphatidylserine on the Activity of the Post-Synaptic GABAA Receptor Complex

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Abstract

Neurotransmitter postsynaptic receptors, as integral membrane proteins, are located within the phospholipid bilayer of the acceptive membrane. Therefore it appears reasonable that the phospholipid environment of the plasma membrane influences and modulates the functional activity of these receptors. In addition, the phospholipid composition of the two leaflets of the bilayer may introduce a further element able to influence the function of these receptors.