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Disorders of Keratinization

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Book cover Dermatology

Abstract

The disorders of keratinization can be best understood within the framework of normal epidermal differentiation. The outermost layer of the epidermis, the stratum corneum, provides the interface between man and his external world. The epidermis is a multiple layered keratinizing squamous epithelium. Besides keratinocytes, there are three other important cell populations in the epidermis: melanocytes, Langerhans cells or epidermal antigen-processing cells and Merkel cells which appear to function as mechanoreceptors interacting with peripheral nerves. On ultrastructural examination, the melanosomes are characterized by immature melanosomes (stage I–II), the Langerhans cells by Birbeck granules, the Merkel cells by dense core granules, and the keratinocytes by tonofilaments and desmosomes.

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Authors and Affiliations

  1. Department of Dermatology and Allergology, Ludwig Maximilians University, Frauenlobstraße 9-11, D-80337, Munich, Germany

    Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco (Emeritus Professor and Chairman), Prof. Dr. med. Gerd Plewig (Professor and Chairman) & Walter H. C. Burgdorf M.D. (Clinical Lecturer)

  2. Department of Dermatology and Venerology, University of Lübeck, Ratzeburger Allee 160, D-23562, Lübeck, Germany

    Prof. Dr. med. Helmut H. Wolff (Professor and Chairman)

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  1. Prof. Dr. med. Dr. h.c.mult. Otto Braun-Falco
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  2. Prof. Dr. med. Gerd Plewig
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  3. Prof. Dr. med. Helmut H. Wolff
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  4. Walter H. C. Burgdorf M.D.
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Braun-Falco, O., Plewig, G., Wolff, H.H., Burgdorf, W.H.C. (2000). Disorders of Keratinization. In: Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97931-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-97931-6_17

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