Summary
As a consequence of the polymorphism of different antigenic systems on blood cells, blood transfusions may lead to alloimmunization of the recipient. This depends on factors involving both the blood-recipient and the transfused blood. Strong antigens such as Rhesus, Kell and HLA often lead to alloimmunization. When alloimmunization is present, cellular blood products with the respective antigens may exhibit impaired function and/or provoke transfusion reactions. Therefore, transfusions to alloimmunized patients have to be carefully matched. Since the HLA-system is very polymorphous, the local donor pool is sometimes too small to obtain the required antigen profile. Therefore, a central registration of HLA (Human Lencocyte Antigens) and blood group typed donors has been established in West-Germany. The results and problems involved are discussed.
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© 1981 Springer-Verlag Berlin Heidelberg
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Schunter, F., Schneider, W. (1981). Central Registration of HLA-Typed Blood Donors. In: Möhr, J.R., Kluge, A. (eds) The Computer and Blood Banking. Lecture Notes in Medical Informatics, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93184-0_5
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DOI: https://doi.org/10.1007/978-3-642-93184-0_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10867-2
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