Abstract
As shown in the previous chapter, the X-linked genes of Drosophila are included in the euchromatic region which never becomes heterochromatic. The male is endowed with one dose, while the female receives two doses of the euchromatic region of the X. During the course of evolution of this insect, the dosage compensation mechanism must have developed one by one for each individual X-linked gene.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
ADINOLFI, M., I. BERNINI, V. CARCASSI, B. LATTE, A. G. MOTULSKI e M. SINISCALCO: Indagine genetiche sulla predisposizione al favismo. Acad. nat. Lincei, R. C., 28, 1 - 26 (1960).
BARROW, E. M., W. R. BULLOCK, and J. B. GRAHAM: The carrier state in PTC deficiency. J. Lab. clin. Med. 55, 936 - 946 (1960).
BEUTLER, E., M. YEH, and V. F. FAIRBANKS: The normal human female as a mosaic of X-chromosome activity: studies using the gene for G-6-PD deficiency as a marker. Proc. nat. Acad. Sci. (Wash.) 48, 9 - 16 (1962).
DAVIDSON, R. G., H. M. NITOwsKY, and B. CHILDS: Demonstration of two populations of cells in the human female heterozygous for glucose-6phosphate dehydrogenase variants. Proc. nat. Acad. Sci. 50, 481 - 485 (1963).
GANS, M.: Etude génétique et physiologique du mutant z de Drosophila melanogaster. Bull. Biol. France Belg. Suppl. 38, 1 - 90 (1953).
ISSELBACHER, K. J., E. P. ANDERSON, K. KURAHASHI, and H. M. KALCKAR: Congenital galactosemia, a single enzymatic block in galactose metabolism. Science 123, 635 - 636 (1956).
KAZAZIAN, H. H. JR., W. J. YOUNG, and B. CHILDS: X-linked 6-phosphogluconate dehydrogenase in Drosophila: Subunit associations. Science 150, 1601 - 1602 (1965).
LYON, M. F.: Gene action in the X-chromosome of the mouse (Mus mus-cul us L.). Nature 190, 372 - 373 (1961).
MULLER, H. J.: Evidence of the precision of genetic adaptation. Harvey Lectures Ser. 43, 165-229 (1947-1948).
NISHIMURA, E. T., T. Y. KOBARA, S. TAKAHARA, H. B. HAMILTON, and S. C. MADDEN: Immunologic evidence of catalase deficiency in human hereditary acatalasemia. Lab. Invest. 10, 333 - 340 (1961).
RAPAPORT, S. I., M. J. PATCH, and F. J. MOORE: Antihemophilic globulin levels in carriers of hemophilia A. J. clin. Invest. 39, 1619 - 1625 (1960).
ROBINSON, A.: The assay of galactokinase and galactose-1-phosphate uridyl transferase activity on human erythrocytes. J. exp. Med. 118, 359 - 370 (1963).
STERN, C.: Ober die additive Wirkung multipler Allele. Biol. Zbl. 49, 241-290 (1929).
TAKAHARA, S., H. B. HAMILTON, J. B. NEIL, T. Y. KOBARA, Y. OGURA, and E. T. NISHIMURA: Hypocatalasemia: a new genetic carrier state. J. clin. Invest. 39, 610 - 619 (1960).
TANAKA, K. R., W. N. VALENTINE, and S. MIwA: Pyruvate kinase (PK) deficiency hereditary nonspherocytic hemolytic anemia. Blood 19, 267-268 (1962).
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1966 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Ohno, S. (1966). The Two Different Means of Achieving Dosage Compensation for X-linked Genes Employed by Drosophila and Mammals. In: Sex Chromosomes and Sex-Linked Genes. Monographs on Endocrinology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88178-7_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-88178-7_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-88180-0
Online ISBN: 978-3-642-88178-7
eBook Packages: Springer Book Archive