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Sepsis pp 150–162Cite as

A Current View of Oxygen Supply Dependency

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 18))

Abstract

Intensive and critical care specialists became particularly interested in oxygen uptake (VO2) and oxygen delivery (DO2) in critically ill patients during the decade of the 1980s. This was in response to the identification of an apparent oxygen supply dependency in some patients, particularly those ill with adult respiratory distress syndrome (ARDS) or with sepsis. Although not the first to report that VO2 was unusually dependent upon DO2, the seminal paper by Danek et al. [1] marked the beginning of increased activity in this area of investigation. Their observation was that VO2 varied directly and linearly with any change in DO2 in ARDS patients. This was not the case in a comparable group of ventilator patients who did not have ARDS but were also in the intensive care unit. Furthermore, the apparent dependence of VO2 upon DO2 in the ARDS patients was seen at very high levels of DO2, well above those that were thought to be critical. Although they recognized that this observation may have had implications for the adequacy of tissue oxygenation in ARDS patients, they were unable to suggest any mechanism. Other publications followed with similar observations and I tried to summarize and to analyze what extraordinary oxygen supply dependency might mean in a review article that appeared in 1984 [2].

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Authors
  1. S. M. Cain
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Editors and Affiliations

  1. Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller-Universität Jena, Bachstraße 18, 07740, Jena, Germany

    Konrad Reinhart

  2. Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Klaus Eyrich

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P. O. Box 12000, 91120, Jerusalem, Israel

    Charles Sprung (Direktor) (Direktor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Cain, S.M. (1994). A Current View of Oxygen Supply Dependency. In: Reinhart, K., Eyrich, K., Sprung, C. (eds) Sepsis. Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85036-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-85036-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85038-7

  • Online ISBN: 978-3-642-85036-3

  • eBook Packages: Springer Book Archive

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