Skip to main content
SpringerLink
Log in

Cytomegalovirus Infection and Neonatal Hepatitis

  • Chapter
Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

  • 83 Accesses

Summary

Neonatal hepatitis is an inflammatory disease of the liver found in early infancy presenting with intrahepatic cholestasis. The etiologies remain unknown in about one half to two thirds of patients. Cytomegalovirus is an important etiologic agent of neonatal hepatitis. Either congenital or perinatal infection by cytomegalovirus can cause neonatal hepatitis. However, the role of cytomegalovirus may be underestimated. An extensive search for evidence of cytomegalovirus in patients with neonatal hepatitis, including urine or saliva culture, serology, immunocytochemistry, and molecular biology studies, may show that the proportion of patients with idiopathic neonatal hepatitis is less than is currently believed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agha FP, Nostrant TT, Abrams GD, Mazanec M, Van Moll L, Gumucio JJ et al. (1986) Cytomegalovirus cholangitis in a homosexual man with acquired immune deficiency syndrome. Am J Gastroenterol 81: 1068–1072

    PubMed  CAS  Google Scholar 

  2. Alagille D (1972) Clinical aspects of neonatal hepatitis. Am J Dis Child 123: 287–291

    PubMed  CAS  Google Scholar 

  3. Alagille D, Odievre M (1979) Liver and biliary tract disease in children. Wiley, New York

    Google Scholar 

  4. Alagille D, Estrada A, Hadchouel M, Gautler M, Odievre M, Dommergues JP (1987) Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 110: 195–200

    Article  PubMed  CAS  Google Scholar 

  5. Balistreri WF, Tabor E, Gerety RJ (1980) Negative serology for hepatitis A and B viruses in 18 cases of neonatal cholestasis. Pediatrics 66: 269–271

    PubMed  CAS  Google Scholar 

  6. Beasley RP, Trepo C, Stevens CE, Szmuness W (1977) The e antigen and vertical transmission of hepatitis B surface antigen. Am J Epidemiol 105: 94–98

    PubMed  CAS  Google Scholar 

  7. Bonkowsky HL, Lee RV, Klatskin G (1975) Acute granulomatous hepatitis — occurrence in cytomegalovirus mononucleosis. JAMA 232: 1284–1288

    Article  Google Scholar 

  8. Brown WR, Sokol RJ, Levin MJ, Silverman A, Tamaru T, Lilly JR, Hall RJ, Cheney M (1988) Lack of correlation between infection with reovirus 3 and extrahepatic biliary atresia or neonatal hepatitis. J Pediatr 113: 670–676

    Article  PubMed  CAS  Google Scholar 

  9. Chang MH, Lee CY, Chen DS, Hsu HC, Lai MY (1987) Fulminant hepatitis in children in Taiwan: the important role of hepatitis B virus. J Pediatr 111: 34–39

    Article  PubMed  CAS  Google Scholar 

  10. Chang MH, Hsu HC, Lee CY, Wang TR, Kao CL (1987) Neonatal hepatitis: a follow-up study. J Pediatr Gastroenterol Nutr 6: 203–207

    Article  PubMed  CAS  Google Scholar 

  11. Chiang WT, Chen HM, Hsieh CY, Tsai WS, Wei PY, Alexander ER (1981) Cytomegalovirus infection of the uterine cervix: local cervical infection and antibody response. Int J Gynaecol Obstet 19: 177–180

    Article  PubMed  CAS  Google Scholar 

  12. Danks DM, Campbell PE, Jack I, Rogers J, Smith AL (1977) Studies of the aetiology of neonatal hepatitis and biliary atresia. Arch Dis Child 52: 360–367

    Article  PubMed  CAS  Google Scholar 

  13. Deutsch J, Smith AL, Danks DM, Campbell PE (1985) Long term prognosis for babies with neonatal liver disease. Arch Dis Child 60: 447–451

    Article  PubMed  CAS  Google Scholar 

  14. Dick MC, Mowat AP (1985) Hepatitis syndrome in infancy — an epidemiologic survey with 10 year follow up. Arch Dis Child 60: 512–516

    Article  PubMed  CAS  Google Scholar 

  15. Dussaix E, Hadchouel M, Tardieu M, Alagille D (1984) Biliary atresia and reovirus type 3 infection. N Engl J Med 310: 658

    PubMed  CAS  Google Scholar 

  16. Embil JA, Krause VW, Haldane EV, Easterbrook KB, Crosby JM (1969) Congenital cytomegalovirus infection: clinical, pathological and virological studies of two fetal cases. Can Med Assoc J 101: 697–705

    Google Scholar 

  17. Finegold MJ, Carpenter RJ (1982) Obliterative cholangitis due to cytomegalovirus: a possible precursor of paucity of intrahepatic bile ducts. Hum Pathol 13: 662–665

    Article  PubMed  CAS  Google Scholar 

  18. Glaser JH, Balistreri WF, Morecki R (1984) Role of reovirus type 3 in persistent infantile cholestasis. J Pediatr 105: 912–915

    Article  PubMed  CAS  Google Scholar 

  19. Hanshaw JB, Betts RF, Simon G, Boynton RC (1965) Acquired cytomegalovirus infection — association with hepatomegaly and abnomal liver-function tests. N Engl J Med 272: 602–609

    Article  PubMed  CAS  Google Scholar 

  20. Henson D (1969) Cytomegalovirus hepatitis in an adult — an autopsy report. Arch Pathol 88: 199–203

    PubMed  CAS  Google Scholar 

  21. Ho M (1982) Cytomegalovirus-biology and infection. Plenum, New York

    Google Scholar 

  22. Landing BH (1974) Considerations of the pathogenesis of neontatal hepatitis, biliary atresia and choledochal cyst — the concept of infantile obstructive cholangiopathy. Prog Pediatr Surg 6: 113–139

    PubMed  CAS  Google Scholar 

  23. Lee CY (1979) Cytomegalovirus as an important cause of neonatal hepatitis in Taiwan. Acta Paediatr Sin 20: 271–272

    Google Scholar 

  24. McCracken GH, Shinefield HR, Cobb K, Rausen AR, Dische MR, Eichenwald HF (1969) Congenital cytomegalic inclusion disease — a longitudinal study of 20 patients. Am J Dis Child 117: 552–539

    Google Scholar 

  25. Mowat AP (1987) Liver disorders in childhood. Butterworth, London

    Google Scholar 

  26. O’Grady JG, Alexander GJM, Sutherland S, Donaldson PT, Harvey F, Potmann B, Calne RY, Williams R (1988) Cytomegalovirus infection and donor/recipient HLA antigens: interdependent co-factors in pathogenesis of vanishing bile-duct syndrome after liver transplantation. Lancet 2: 302–305

    Article  PubMed  Google Scholar 

  27. Oppenheimer EH, Esterly JR (1973) Cytomegalovirus infection: a possible cause of biliary atresia. Am J Pathol 71: 2a

    Google Scholar 

  28. Panjvani ZFK, Hanshaw JB (1981) Cytomegalovirus in the perinatal period. Am J Dis Child 135: 56–60

    PubMed  CAS  Google Scholar 

  29. Pretorius PJ, Roode H (1974) Obstructive jaundice in early infancy. S Afr Med J 48: 811

    PubMed  CAS  Google Scholar 

  30. Reller LB (1973) Granulomatous hepatitis associated with acute cytomegalovirus infection. Lancet 2: 20–22

    Google Scholar 

  31. Sacks SL (1984) Cytomegalovirus hepatitis. Evidence for direct hepatic viral infection using monoclonal antibodies. Gastroenterology 86: 346–350

    PubMed  CAS  Google Scholar 

  32. Silverman A, Roy CR (1983) Pediatric clinical gastroenterology. Mosby, St Louis

    Google Scholar 

  33. Sinatra FR, Shah P, Wessman JY, Thomas DW, Merritt RJ, Tong MJ (1982) Perinatal transmitted acute icteric hepatitis B in infants born to hepatitis B surface antigen-positive and antihepatitis B e-positive carrier mothers. Pediatrics 90: 557–559

    Google Scholar 

  34. Snover DC, Horwitz CA (1984) Liver disease in cytomegalovirus mononucleosis. A light microscopical and immunoperoxidase study of six cases. Hepatology 4: 408–412

    Article  PubMed  CAS  Google Scholar 

  35. Wyatt JP, Saxton J, Lee RS, Pinkerton H (1950) Generalized cytomegalic inclusion disease. J Pediatr 36: 271–294

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

    Mei-Hwei Chang & Chin-Yun Lee

Authors
  1. Mei-Hwei Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chin-Yun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Chang, MH., Lee, CY. (1993). Cytomegalovirus Infection and Neonatal Hepatitis. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84850-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84852-0

  • Online ISBN: 978-3-642-84850-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation