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Verhandlungen der Deutschen Gesellschaft für Innere Medizin pp 223–244Cite as

Neue Aspekte der Arteriosklerose

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Part of the book series: Verhandlungen der Deutschen Gesellschaft für Innere Medizin ((VDGINNERE,volume 97))

Zusammenfassung

Einer ausgeprägten arteriosklerotischen Läsion ist nicht anzusehen, welche Schritte in ihrer Entwicklung abgelaufen sind und welche das Geschehen initiiert haben. Wir wissen allerdings, daß die Länder mit hohem durchschnittlichen Plasmacholesterinspiegel eine hohe Rate an koronarer Herzkrankheit haben, während die Länder mit niedrigem Gesamtcholesterin von 160 mg/dl oder darunter dieses Problem nicht kennen, trotz oftmals erheblicher Prävalenz anderer Risikofaktoren wie Hypertonus und Rauchen. Daher muß dem Plasmacholesterinspiegel eine zentrale Rolle zukommen [1]. Während die experimentelle Arterioskleroseforschung lange Zeit davon ausging, daß es primär zu einer Endothelläsion kommen müsse, wissen wir heute, daß der erste Schritt bei intaktem Endothel ablaufen kann und kompliziertere Vorgänge beinhaltet als bloße Insudation von Cholesterin in die Arterienwand.

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Authors and Affiliations

  1. Hamburg, Deutschland

    H. Greten (Vorsitz)

  2. Innsbruck, Österreich

    G. Utermann (Vorsitz)

  3. Medizinische Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg, Deutschland

    E. Windler & H. Greten

  4. Institut für Medizinische Biologie und Genetik, Universität Innsbruck, Deutschland

    G. Utermann

  5. Abteilung für Sozialmedizin und Epidemiologie, Ruhr-Universität Bochum, Deutschland

    U. Keil, J. Stieber, A. Döring, H. W. Hense, H. Löwe, M. Lewis & H. D. Bolte

  6. II. Medizinische Klinik, Klinikum Großhadern, Universität München, Deutschland

    P. Schwandt

  7. Klinik II und Poliklinik für Innere Medizin, Universität Köln, Deutschland

    W. Krone & D. Müller-Wieland

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    Klaus Miehlke

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Greten, H. et al. (1991). Neue Aspekte der Arteriosklerose. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84710-3_6

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