Abstract
The management of patients with ductal carcinoma in situ (DCIS) is among the most controversial topics in the field of breast cancer. In the past, DCIS was an uncommon lesion that usually presented as a palpable mass. With the advent of Screening mammography the incidence of DCIS has increased markedly. The success of breast-conserving treatment for invasive carcinomas (National Institutes of Health 1991) has also led to increased interest in avoiding mastectomy in patients with noninvasive cancers. However, the traditional therapy of DCIS has been mastectomy.
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References
Aasmundstad TA, Haugen OA (1990) DNA ploidy in intra-ductal breast carcinomas. Eur J Cancer 26: 956–959
Abbes M, Caruso F, Bourgeon Y (1988) Subcutaneous mastectomy: a review of 130 cases. Int Surg 73: 107–111
Allred DC, Clark GM, Molina R et al (1990) Immunocyto-chemical evaluation of HER-2/neu oncogene expression in different evolutionary stages of breast carcinoma and correlation with clinical-pathological characteristics. Proc Am Soc Clin Oncol 9: 23 (Abstract)
Arnesson L-G, Smeds S, Fagerberg G, Grontoft O (1989) Follow-up of two treatment modalities for ductal carci-noma in situ of the breast. Br J Surg 76: 672–675
Ashikari R, Hadju SI, Robbins GF (1971) Intraductal carcinoma of the breast (1960-1969). Cancer 28: 1182-1187 Ashikari R, Huvos AG, Snyder RE (1977) Prospective study of non-infiltrating carcinoma of the breast. Cancer 39: 435–439
Asselain B, Contesso G, Zafrani B et al (1990) Etude inter-centre de 387 cas de carcinomes intracanalaires du sein: premieres conclusions. Bull Cancer (Paris) 77: 643–644 (Abstract)
Austin DF, Reynolds P, Boyd PT et. al (1989) Progress in the war against cancer (letter). N Engl J Med 321: 1197–1198
Baird RM, Worth A, Hislop G (1990) Recurrence after lumpectomy for comedo-type intraductal carcinoma of the breast. Am J Surg 159: 479–481
Baker LH (1982) Breast cancer detection demonstration project: five-year summary report. CA 32: 194–225
Barnes DM, Meyer JS, Gonzalez JG et al (1991) Relationship between c-erbB-2 immunoreactivity and thymidine labelling index in breast carcinoma in situ. Breast Cancer Res Treat 18: 11–17
Bartkova J, Barnes DM, Millis RR, Gullick WJ (1990) Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ. Hum Pathol 21: 1164–1167
Bedwani R, Vana J, Rosner D et al (1981) Management and survival of female patients with “minimal” breast cancer: as observed in the long-term and short-term surveys of the American College of Surgeons. Cancer 47: 2769–2778
Benz C, Thor A, Edgerton S, He M, Liu E (1991) HER2/neu overexpression and gene amplification in comedo-type in situ breast cancers. Proc Am Soc Clin Oncol 10: 46 (Abstract)
Bornstein BA, Recht A, Connolly JL et al (1991) Results of treating ductal carcinoma in situ of the breast with conservative surgery and radiation therapy. Cancer 67: 7–13
Brandon C, Raju U, Rebner M (1990) Mammographie and pathologic correlation in the appearance of subtypes of ductal carcinoma in situ. Radiology 177 (P): 137 (Abstract)
Brown PW, Silverman J, Owens E et al (1976) Intraductal “noninfiltrating” carcinoma of the breast. Archiv Surg 111: 1063–1067
Ciatto S, Bonardi R, Cataliotti L, Cardona G (1990) Intraductal breast carcinoma: review of a multicenter series of 350 cases. Tumori 76: 552–554
Cooke TG (1988) Prognostic value of cellular DNA content in the management of ductal carcinoma in situ of the female breast. EORTC In Situ Breast Cancer Workshop, Castle Marquete, the Netherlands, November 24 - 25, 1988
Cutuli BF, Teissier E, Methlin A et al (1989) Conservative treatment of in situ breast carcinoma: preliminary results. Proceedings of the 5th European Conference on Clinical Oncology P-0912 (Abstract)
Delouche G, Bachelot F, Premont M, Kurtz JM (1987) Conservation treatment of early breast cancer: long-term results and complications. Int J Radiat Oncol Biol Phys 13: 29–34
Farrow JH (1970) Current concepts in the detection and treatment of the earliest of the early breast cancers. Cancer 25: 468–477
Fentiman IS, Fagg N, Millis RR, Hayward JL (1986) In situ ductal carcinoma of the breast: implications of disease pattern and treatment. Eur J Surg Oncol 12: 261–266
Fisher B, Constantino J, Redmond C (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-reeeptor positive tumors. N Engl J Med 320: 479–484
Fisher ER, Sass R, Fisher B (1986) Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol 6). I. Intraductal carcinoma ( DCIS ). Cancer 57: 197–208
Fisher ER, Leeming RL, Anderson S et al (1991) Conservative management of intraductal carcinoma ( DCIS) of the breast. J Surg Oncol 47: 139–147
Frykberg ER, Santiago F, Betsill WL, O’Brien PH (1987) Lobular carcinoma in situ of the breast. Surg Gynecol Obstet 164: 285–301
Gallagher WJ, Koerner FC, Wood WC (1989) Treatment of intraductal carcinoma with limited surgery: long-term follow-up. J Clin Oncol 7: 376–380
Goldschmidt RA, Prindiville S, Merkel DE et al (1990) Comparison of HER-2 expression, histology, and flow cytometry in ductal carcinoma-in-situ. Breast Cancer Res Treat 16: 191 (Abstract)
Goldwyn RM (1977) Subcutaneous mastectomy. N Engl J Med 297: 503–505
Graham MD, Lakhani S, Gazet J-C (1991) Breast conserving surgery in the management of in situ breast Carcinoma. Eur J Surg Oncol 17: 258–264
Gump FE, Jicha DL, Ozello L (1987) Ductal carcinoma in situ (DCIS): a revised concept. Surgery 102: 790–795
Haffty BG, Peschel RE, Papadopoulos D, Pathare P (1990) Radiation therapy for ductal carcinoma in situ of the breast. Conn Med 54: 482–484
Holland R, Henricks JHCL, Verbeek ALM et al (1990) Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet 335: 519–522
Kinne DW (1991) Clinical management of lobular carcinoma in situ. In: Harris JR, Hellman S, Henderson IC, Kinne DW (eds) Breast diseases, 2nd edn. Lippincott, Philadelphia, pp 239–244
Kinne DW, Petrek JA, Osborne MP et al (1989) Breast carcinoma in situ. Arch Surg 124: 33–36
Kurtz JM, Jacquemier J, Amalric R et al (1990) Breast-conserving therapy for macroscopically multiple cancers. Ann Surg 212: 38–44
Kuske R, Compaan P, Cross M et al (1989) Breast conservation therapy: 417 breast cancers with a minimum follow-up period of five years. Int J Radiat Oncol Biol Phys 17 [Suppl 1]: 235 - 236 (Abstract)
Lagios MD (1990) Duct carcinoma in situ: pathology and treatment. Surg Clin N Amer 70: 853–871
Lagios MD, Westdahl PR, Margolin FR, Rose MR (1982) Duct carcinoma in situ: relationship of occult invasion, multicentricity, lymph node metastases, and short-term treatment failures. Cancer 50: 1309–1314
Lagios MD, Margolin FR, Westdahl PR, Rose MR (1989) Mammographically detected duct carcinoma in situ: frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence. Cancer 63: 618–624
Lemanne D, Simon M, Martino S, Swanson M (1991) Breast carcinoma in situ (CIS): greater rise in ductal carcinoma in situ (DCIS) vs lobular carcinoma in situ (LCIS). Proc Am Soc Clin Oncol 10: 45 (Abstract)
Leopold KA, Recht A, Schnitt SJ et al (1989) Results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast. Int J Radiat Oncol Biol Phys 16: 11–16
Locker AP, Ellis IO, Bell J et al (1991) Erb B2 expression in ductal carcinoma-in-situ (DCIS) of the breast. Eur J Surg Oncol 17: 106–107 (Abstract)
Lodato RF, Maguire HC, Greene MI et al (1990) Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast. Mod Pathol 3: 449–454
Mayr NA, Staples JJ, Robinson RA et al (1991) Morphometric studies in intraductal breast carcinoma using computerized image analysis. Cancer 67: 2805–2812
McCormick B, Rossen PP, Kinne D et al (1991) Duct carcinoma in situ of the breast: an analysis of local control after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys 21: 289–292
Meyer JS (1986) Cell kinetics of histologic varients of in situ breast carcinoma. Breast Cancer Res Treat 7: 171–180
National Institutes of Health Consensus Conference (1991) Treatment of early-stage breast cancer. JAMA 265: 391–395
Nielsen KV, Blichert-Toft M, Andersen J (1989) Chromosome analysis of in situ breast cancer. Acta Oncol 28: 919–922
Osteen RT (1991) Paget disease of the nipple. In: Harris JR, Hellman S, Henderson IC, Kinne DW (eds) Breast diseases, 2nd edn. Lippincott, Philadelphia, pp 797–804
Page DL, Dupont WD, Rogers LW, Landenberger M (1982) Intraductal carcinoma of the breast: follow-up after biopsy only. Cancer 46: 919–925
Price P, Sinnett HD, Gusterson B et al (1990) Ductal carcinoma in situ: predictors of local recurrence and progression in patients treated by surgery alone. Br J Cancer 61: 869–872
Recht A, Danoff BS, Solin LJ et al (1985) Intraductal carcinoma of the breast: results of treatment with excisional biopsy and irradiation. J Clin Oncol 3: 1339–1343
Recht A, Connolly JL, Schnitt SJ, Harris JR (1989) Therapy of in-situ cancer. Hematol/Oncol Clin N Am 3 (4): 691–708
Ringberg A, Palmer B, Linell F et al (1991) Bilateral and multifocal breast carcinoma: a clinical and autopsy study with special emphasis on carcinoma in situ. Eur J Surg Oncol 17: 20–29
Rosen PP, Braun DW, Kinne DE (1980) The clinical significance of pre-invasive breast carcinoma. Cancer 46: 919–925
Rosner D, Bedwani RN, Vana J et al (1980) Noninvasive breast carcinoma: results of a national survey by the American College of Surgeons. Ann Surg 192: 139–147
Ryoo MC, Kagan AR, Wollin M et al (1989) Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy for early mammary carcinoma. Radiology 172: 555–559
Salvadori B (1988) Ductal carcinoma in situ: retrospective analysis of 50 cases, including 19 cases treated with breast conservation. EORTC In Situ Breast Cancer Workshop. Castle Marquete, the Netherlands, November 24–25, 1988
Schnitt SJ (1991) Pathology of in situ carcinoma. In: Harris JR, Hellman S, Henderson IC, Kinne DW (eds) Breast diseases, 2nd edn. Lippincott, Philadelphia, pp 229–232
Schnitt SJ, Silen W, Sadowsky NL et al (1988) Current concepts: ductal carcinoma in situ (intraductal carcinoma) of the breast. N Engl J Med 318: 898–903
Schwartz GF, Patchefsky AS, Feig SA et al (1980) Clinically occult breast cancer: muticentricity and implications for treatment. Ann Surg 191: 8–12
Schwartz GF, Patchefsky AS, Finklestein SD et al (1989) Nonpalpable in situ ductal carcinoma of the breast: predictors of multicentricity and microinvasion and implications for treatment. Arch Surg 124: 29–32
Silverstein MJ, Waisman JR, Gamagami P et al (1991a) Duct carcinoma in situ (DCIS): 224 consecutive cases without microinvasion. Proc Am Soc Clin Oncol 10: 53 (Abstract)
Silverstein MJ, Waisman JR, Gierson ED et al (1991b) Radiation therapy for intraductal carcinoma: is it an equal alternative? Arch Surg 126: 424–428
Silverstein MJ, Gierson ED, Colburn WJ et al (1991c) Axillary lymphadenectomy for intraductal carcinoma of the breast. Surg Gynecol Obstet 172: 211–214
Solin LJ, Fowble BL, Schultz DJ et al (1990) Definitive irradiation for intraductal carcinoma of the breast. Int J Radiat Oncol Biol Phys 19: 843–850
Solin LJ, Recht A, Fourquet A et al (1991) Ten-year results of breast-conserving surgery and definitive irradiation for intraductal carcinoma of the breast. Cancer 68: 2337–2344
Stotter AT, McNeese M, Oswald MJ et al (1990) The role of limited surgery with irradiation in primary treatment of ductal in situ breast cancer. Int J Radiat Oncol Biol Phys 18: 283–287
Sunshine JA, Moseley HS, Fletcher WS, Krippaehne WW (1985) Breast carcinoma in situ: a retrospective review of 112 cases with a minimum 10-year follow-up. Am J Surg 150: 44–51
Van de Vijver MJ, Peterse JL, Mooi WJ et al (1988a) Neu-protein overexpression in breast cancer: association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med 319: 1239–1245
Van de Vijver MJ, Peterse JL, Mooi WJ et al (1988b) Neu protein overexpression and neu gene amplification in comedo type ductal carcinoma in situ. EORTC In Situ Breast Cancer Workshop, Castle Marquete, the Netherlands, November 24–25, 1988
Von Rueden DG, Wilson RE (1984) Intraductal carcinoma of the breast. Surg Obstet Gynecol 158: 105–111
Wanebo HJ, Huvos AG, Urban JA (1974) Treatment of minimal breast cancer. Cancer 33: 349–357
Westbrook KC, Gallagher HS (1975) Intraductal carcinoma of the breast: a comparative study. Am J Surg 130: 667–670
Zafrani B (1988) Conservative management of intraductal breast carcinoma with tumorectomy and radiation therapy: updated results. EORTC In Situ Breast Cancer Workshop, Castle Marquete, the Netherlands, November 24–25, 1988
Zafrani B, Fourquet A, Vilcoq JR et al (1986) Conservative management of intraductal breast carcinoma with tumorectomy and radiation therapy. Cancer 57: 1299–1301
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Recht, A. (1993). How Should We Treat Ductal Carcinoma In Situ?. In: Fletcher, G.H., Levitt, S.H. (eds) Non-Disseminated Breast Cancer. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84593-2_14
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DOI: https://doi.org/10.1007/978-3-642-84593-2_14
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