Abstract
In 1680, a painter to the Spanish court of King Charles II, Juan Carreno de Miranda, immortalized on canvas a six year old obese girl who was known for her “feeblemindedness” and “bad temper”. She has almond-shaped palpebral fissures, a down-turned mouth, small hands, and central obesity, all characteristic of Prader-Willi Syndrome. She hangs in the Prado Museum in Madrid, clad in one painting, nude in the other, a testimony to the fact that the condition we now know as Prader-Willi Syndrome has existed for centuries. But it was not until 1956 that Drs. Prader, Labhart and Willi first described the pattern of abnormalities which includes low muscle tone, incomplete sexual development, obesity, and mental handicap (Prader et al, 1956) and which now bears their names.
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© 1992 Springer-Verlag Berlin Heidelberg
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Cassidy, S.B. (1992). Introduction and Overview of Prader-Willi Syndrome. In: Cassidy, S.B. (eds) Prader-Willi Syndrome. NATO ASI Series, vol 61. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84283-2_1
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DOI: https://doi.org/10.1007/978-3-642-84283-2_1
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