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The Thymus pp 209–215Cite as

The Thymus and Myasthenia Gravis

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Myasthenia gravis (MG) is the best known organ-specific autoimmune disease; it is caused by a loss of functional acetylcholine receptors (AChR) at the neuromuscular junction, resulting in fatigable weakness of voluntary muscle. Diagnostically relevant serum antibodies against AChR are present in about 90% of patients with generalized MG.

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References

  • Batra P, Hermann C, Mulder D (1987) Mediastinal imaging in myasthenia gravis: correlation of chest radiography, CT, MR and surgical findings. AJR 148: 515

    PubMed  CAS  Google Scholar 

  • Bernatz PE, Harrison EG, Clagett OT (1961) Thymoma: A clinicopathologic study. J Thorac Cardiovasc Surg 42: 424

    PubMed  CAS  Google Scholar 

  • Berrih-Aknin S, Morel E, Raimond F et al. (1987) The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases. Ann NY Acad Sci 505: 50

    Article  PubMed  CAS  Google Scholar 

  • Brown LR, Muhm JR, Gray JE (1980) Radiographic detection of thymoma. AJR 134: 1181

    PubMed  CAS  Google Scholar 

  • Brown LR, Muhm JR, Sheedy II PF, Unni KK, Bernatz PE, Hermann RC (1983) The value of computed tomography in myasthenia gravis. AJR 140: 31

    PubMed  CAS  Google Scholar 

  • Compston DAS, Vincent A, Newsom-Davis J, Batchelor JR (1980) Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103: 579

    Article  PubMed  CAS  Google Scholar 

  • Drachman DB (ed) (1987) Myasthenia gravis: biology and treatment. Ann NY Acad Sci 505

    Google Scholar 

  • Ellis K, Austin JHM, Jaretzki A (1988) Radiologic detection of thymoma in patients with myasthenia gravis. AJR 151: 873

    PubMed  CAS  Google Scholar 

  • Emskötter T, Trampe H, Lachenmayer L (1988) Kernspintomographie bei Myasthenia gravis. Dtsch Med Wochenschr 113: 1508

    Article  PubMed  Google Scholar 

  • Erb W (1879) Zur Kasuistik der bulbären Lähmungen: Über einen neuen wahrscheinlich bulbären Symptomen-Komplex. Arch Psychiatr Nervenkrankh 9: 336

    Google Scholar 

  • Fon GT, Bein ME, Manouso AA, Keesey JC, Lupetin AR, Wong WS (1982) Computed tomography of the anterior mediastinum in myasthenia gravis. Radiology 142: 135

    PubMed  CAS  Google Scholar 

  • Glathe S, Neufang KF, Haupt FW (1989) Was leistet die radiologische Thymusdiagnostik bei der Myasthenia gravis? Röntgenblätter 42: 455

    PubMed  CAS  Google Scholar 

  • Goldstein G, Mackay IR (1969) Thymic tumours and systemic diseases associated with thymomas. In: Goldstein G, Mackay IR (eds) The human thymus. William Heinemann Medical Books, London, pp 194–227

    Google Scholar 

  • Gürtler KF, Janzen RWC, Hagemann J, Otto HF (1982) Computertomographie des Mediastinums bei Myasthenia gravis pseudoparalytica. ROFO 136: 35

    Article  PubMed  Google Scholar 

  • Kaye AD, Jenssen R, Arger PH et al. (1983) Mediastinal computed tomography in myasthenia gravis. J Comput Tomogr 7: 273

    Article  PubMed  CAS  Google Scholar 

  • Keesey J, Bein M, Mink J et al. (1980) Detection of thymoma in myasthenia gravis. Neurology 30: 233

    PubMed  CAS  Google Scholar 

  • Levine GD, Rosai J (1978) Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 9: 495

    Article  PubMed  CAS  Google Scholar 

  • Melms A, Schalke BCG, Kirchner T, Müller-Hermelink HK, Albert E, Wekerle H (1988) Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. J Clin Invest 81: 902

    Article  PubMed  CAS  Google Scholar 

  • Mink JH, Bein ME, Sukov R, Herrmann C, Winter J, Sample WF, Mulder D (1978) Computed tomography of the anterior mediastinum in patients with myasthenia gravis and suspected thymoma. AJR 130: 239

    PubMed  CAS  Google Scholar 

  • Moore AV, Korobkin M, Powers B et al. (1982) Thymoma detection by mediastinal CT: patients with myasthenia gravis. AJR 138: 217

    PubMed  CAS  Google Scholar 

  • Müller-Hermelink HK, Marino M, Palestro G (1986) Pathology of thymic epithelial tumors. Curr Top Pathol 75: 207

    Article  PubMed  Google Scholar 

  • Namba T, Brunner NG, Grob D (1978) Myasthenia gravis in patients with thymoma with particular reference to and after thymectomy. Medicine 57: 411

    Article  PubMed  CAS  Google Scholar 

  • Newsom-Davis J, Willcox N, Schluep M et al. (1987) Immunological heterogeneity and cellular mechanisms in myasthenia gravis. Ann NY Acad Sci 505: 12

    Article  PubMed  CAS  Google Scholar 

  • Oosterhuis HJGH (1981) Observations of the natural history of myasthenia gravis and the effect of thymectomy. Ann NY Acad Sci 377: 678

    Article  PubMed  CAS  Google Scholar 

  • Oosterhuis HJGH (1984) Myasthenia gravis. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Oosterhuis HJGH (1989) The natural course of myasthenia gravis: a long term follow up study. J Neurol Neurosurg Psychiatry 52: 1121

    Article  PubMed  CAS  Google Scholar 

  • Osserman KE (1958) Myasthenia gravis. Grune & Stratton, New York

    Google Scholar 

  • Patrick J, Lindstrom JM (1973) Autoimmune response to acetylcholine receptor. Science 180: 871

    Article  PubMed  CAS  Google Scholar 

  • Schluep M, Willcox N, Ritter MA, Newsom-Davis J, Larche M, Brown AN (1988) Myasthenia gravis thymus: clinical, histological and culture correlations. J Autoimmunol 82: 1295

    Google Scholar 

  • Schnyder P, Candardjis G (1987) Computed tomography of thymic abnormalities. Eur J Radiol 7: 107

    PubMed  CAS  Google Scholar 

  • Schumm F, Wiethölter H, Fateh-Moghadam A, Dichgans J (1985) Thymectomy in myasthenia with pure ocular symptoms. J Neurol Neurosurg Psychiatry 48: 332

    Article  PubMed  CAS  Google Scholar 

  • Simpson JA (1960) Myasthenia gravis. A new hypothesis. Scott Med J 5: 419

    Google Scholar 

  • Sommer N, Harcourt G, Willcox N, Newsom-Davis J(1988) Acetylcholine receptor-specific T-lymphocyte responses in thymus, thymoma and lymph nodes from patients with myasthenia gravis. J Neurol Neurosurg Psychiatry 51: 1358

    Google Scholar 

  • Thorvinger B, Lyttkens K, Samuelsson L (1987) Computed tomography of the thymus gland in myasthenia gravis. Acta Radiol 28: 399

    Article  PubMed  CAS  Google Scholar 

  • Tola MR, Granieri E, Paolino E, Caniatti L, Quatrale R, Mazzanti B, D’Alessandro R (1989) Epidemiological study of myasthenia gravis in the province of Ferrara, Italy. J Neurol 236: 388

    Article  PubMed  CAS  Google Scholar 

  • Weigert C (1901) Pathologisch-anatomischer Beitrag zur Erb’schen Krankheit (Myasthenia gravis). Neurologisches Zentralblatt 20: 597

    Google Scholar 

  • Weiss C, Dinkel E, Wimmer B, Schildge J, Grosser G (1987) Der Thymus im Computertomogramm. Radiologe 27: 414

    PubMed  CAS  Google Scholar 

  • Wekerle H, Hohlfeld R, Ketelsen UP, Kalden JR, Kalies J (1981) Thymic myogenesis, T-lymphocytes and the pathogenesis of myasthenia gravis. Ann NY Acad Sci 377: 455

    Article  PubMed  CAS  Google Scholar 

  • Wilkins EW, Edmunds LH, Castleman B (1966) Cases of thymoma at the Massachusetts General Hospital. J Thorac Cardiovasc Surg 52: 322

    PubMed  Google Scholar 

  • Willcox N, Vincent A (1988) Myasthenia gravis as an example of organ-specific autoimmune disease. In: Bird G, Calvert JE (eds) B-Lymphocytes in human disease. Oxford University Press, Oxford, p 469

    Google Scholar 

  • Willcox N, Schluep M, Sommer N, Campana D, Janossy G, Brown AN, Newsom-Davis J (1989) Variable corticosteroid sensitivity of thymic cortex and medullary peripheral-type lymphoid tissue in myasthenia gravis patients: structural and functional effects. Quart J Med 73: 1071

    PubMed  CAS  Google Scholar 

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Authors
  1. H. Wiethölter
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  2. E. Willich
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  3. E. Walter
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Editor information

Editors and Affiliations

  1. Abteilung Röntgendiagnostik, Radiologische Klinik der Universität Tübingen, Hoppe-Seyler-Straße 3, W-7400, Tübingen, Germany

    Eberhard Walter

  2. Abteilung für Pädiatrische Radiologie, Klinikum der Universität Heidelberg —Kinderklinik—, Im Neuenheimer Feld 153, W-6900, Heidelberg, Germany

    Eberhard Willich

  3. Department of Radiology, University of California, Medical Center, 505 Parnassus Ave., San Francisco, CA, 94143, USA

    W. Richard Webb M.D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Wiethölter, H., Willich, E., Walter, E. (1992). The Thymus and Myasthenia Gravis. In: Walter, E., Willich, E., Webb, W.R. (eds) The Thymus. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84192-7_11

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  • DOI: https://doi.org/10.1007/978-3-642-84192-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84194-1

  • Online ISBN: 978-3-642-84192-7

  • eBook Packages: Springer Book Archive

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