Pathological Anatomy of Cancer Pain

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Since pain is a functional and multifactorial phenomenon (cf. Bonica 1979, Rolf and Brune 1982, Strempel 1981), it is not usually accessible to morphological methods. In particular, the study of cancer pain by the pathological anatomist is hampered by the lack of information as to whether or not pain symptoms have been present clinically in his cases. Therefore, I should like first of all to thank my clinical colleagues who have provided information to make possible the following review of painful organ and tissue changes (cf. also Bonadonna and Molinari 1979; Bonica 1979; Foley 1979; Schlegel 1982; Twycross 1978).