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Adverse Effects of Dexamethasone Treatment in Preterm Neonates

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Book cover Intensive Care in Childhood

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 25))

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Abstract

Corticosteroids are frequently used in the perinatal period. In case of imminent preterm birth prenatal dexamethasone or betamethasone therapy has been shown to decrease the incidence of respiratory distress, periventricular hemorrhage and necrotizing enterocolitis [1]. Long-term adverse effects on neurodevelopmental outcome have not been demonstrated. On the contrary, a favorable effect on neurological abnormality at follow-up seems present [1].

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References

  1. Crowley PA. (1995) Antenatal corticosteroid therapy: A meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 173:322–335.

    Article  PubMed  CAS  Google Scholar 

  2. Avery GB, Fletcher AB, Kaplan M, Brudno DS. (1985) Controlled trial of dexamethasone in respirator-dependent infants with bronchopulmonary dysplasia. Pediatrics 75:106–111.

    PubMed  CAS  Google Scholar 

  3. Gladstone IM, Ehrenkranz RA, Jacobs HC. (1989) Pulmonary function tests and fluid balance in neonates with chronic lung disease during dexamethasone treatment. Pediatrics 84:1072–1076.

    PubMed  CAS  Google Scholar 

  4. Cummings JJ, D’Eugenio DB, Gross SJ. (1989) A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. N Engl J Med 320:1505–1510.

    Article  PubMed  CAS  Google Scholar 

  5. Collaborative Dexamethasone Trial Group (1991) Dexamethasone therapy in neonatal chronic lung disease: an international placebo-controlled trial. Pediatrics 88:421–427.

    Google Scholar 

  6. Kari MA, Heinonen K, Ikonen RS, Koivisto M, Raivio KO. (1993) Dexamethasone treatment in preterm infants at risk for bronchopulmonary dysplasia. Arch Dis Child 68:566–569.

    Article  PubMed  CAS  Google Scholar 

  7. Brozanski BS, Jones JG, Gilmour CH, et al (1995) Effect of pulse dexamethasone therapy on the incidence and severity of chronic lung disease in the very low birth weight infant. J Pediatr 126:769–776.

    Article  PubMed  CAS  Google Scholar 

  8. Durand M, Sardesai S, McEvoy C. (1995) Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: A randomized, controlled trial. Pediatrics 95:584–590.

    PubMed  CAS  Google Scholar 

  9. O’Shea TM, Kothadia JM, Klinepeter KL, Goldstein DJ, Jackson B, Dillard RG. (1993) Follow-up of preterm infants treated with dexamethasone for chronic lung disease. Am J Dis Child 147:658–661.

    PubMed  Google Scholar 

  10. Furman L, Hack M, Watts C, et al (1995) Twenty-month outcome in ventilator-dependent, very low birth weight infants born during the early years of dexamethasone therapy. J Pediatr 126:434–440.

    Article  PubMed  CAS  Google Scholar 

  11. Jones R, Wincott E, Elbourne D, Grant A. (1995) Controlled trial of dexamethasone in neonatal chronic lung disease: A 3-year follow-up. Pediatrics 96:897–906.

    PubMed  CAS  Google Scholar 

  12. Noble-Jamieson CM, Regev R, Silverman M. (1989) Dexamethasone in neonatal chronic lung disease: pulmonary effects and intracranial complications. Eur J Pediatr 148:365–367.

    Article  PubMed  CAS  Google Scholar 

  13. Schwarze J, Bartmann P. (1994) Influence of dexamethasone on lymphocyte proliferation in whole blood cultures of neonates. Biol Neonate 65:295–301.

    Article  PubMed  CAS  Google Scholar 

  14. Batton DG, Roberts C, Trese M, Maiseis MJ. (1992) Severe retinopathy of prematurity and steroid exposure. Pediatrics 90:534–536.

    PubMed  CAS  Google Scholar 

  15. Ramanathan R, Siassi B, deLemos RA. (1995) Severe retinopathy of prematurity in extremely low birth weight infants after short-term dexamethasone therapy. J Perinatol 15:178–182.

    PubMed  CAS  Google Scholar 

  16. Ng PC, Brownlee KG, Dear PR. (1991) Gastroduodenal perforation in preterm babies treated with dexamethasone for bronchopulmonary dysplasia. Arch Dis Child 66:1164–1166.

    Article  PubMed  CAS  Google Scholar 

  17. Wolf YG, Reyna T, Schropp KP, Harmel RP, Jr. (1991) Steroid therapy and duodenal ulcer in infants. J Pediatr Gastroenterol Nutr 12:269–271.

    Article  PubMed  CAS  Google Scholar 

  18. Yeh TF, Torre JA, Rastogi A, Anyebuno MA, Pildes RS. (1990) Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a doubleblind controlled study. J Pediatr 117:273–282.

    Article  PubMed  CAS  Google Scholar 

  19. Werner JC, Sicard RE, Hansen TW, Solomon E, Cowett RM, Oh W. (1992) Hypertrophic cardiomyopathy associated with dexamethasone therapy for bronchopulmonary dysplasia. J Pediatr 120:286–291.

    Article  PubMed  CAS  Google Scholar 

  20. Brand PLP, van Lingen RA, Brus F, Talsma MD, Elzenga NJ. (1993) Hypertrophic obstructive cardiomyopathy as a side effect of dexamethasone treatment for bronchopulmonary 1 dysplasia. Acta Paediatr 82:614–617.

    Article  PubMed  CAS  Google Scholar 

  21. Evans N. (1994) Cardiovascular effects of dexamethasone in the preterm infant. Arch Dis Child 70: F25–30.

    Article  CAS  Google Scholar 

  22. Ohlsson A, Calvert SA, Hosking MC, Shennan AT. (1992) Randomized controlled trial of dexamethasone treatment in very-low-birth-weight infants with ventilator-dependent chronic lung disease. Acta Paediatr 81:751–756.

    Article  PubMed  CAS  Google Scholar 

  23. Bos AF, van Asperen RM, Van Eykern LA, Zijlstra WG, Okken A. (1994) Heart rate, heart rate variability and metabolic rate in preterm infants with bronchopulmonary dysplasia in the first week of dexamethasone treatment. J Physiol 479:23P-24P (Abst)

    Google Scholar 

  24. Mulder EJH, Derks JB, Zonneveld MF, Bruinse HW, Visser GHA. (1994) Transient reduction in fetal activity and heart rate variation after maternal betamethasone administration. Early Hum Dev 36:49–60.

    Article  PubMed  CAS  Google Scholar 

  25. Ferrara TB, Couser RJ, Hoekstra RE. (1990) Side effects and long-term follow-up of corticosteroid therapy in very low birthweight infants with bronchopulmonary dysplasia. J Perinatol 10:137–142.

    PubMed  CAS  Google Scholar 

  26. Williams AF, Jones M. (1992) Dexamethasone increases plasma amino acid concentrations in bronchopulmonary dysplasia. Arch Dis Child 67:5–9.

    Article  PubMed  CAS  Google Scholar 

  27. Brownlee KG, Ng PC, Henderson MJ, Smith M, Green JH, Dear PR. (1992) Catabolic effect of dexamethasone in the preterm baby. Arch Dis Child 67:1–4.

    Article  PubMed  CAS  Google Scholar 

  28. Bos AF, van Asperen RM, Reijngoud DJ, Okken A. (1994) Plasma amino acid levels in preterm infants with bronchopulmonary dysplasia on the first days of dexamethasone treatment. Pediatr Res 36:7A. (Abst).

    Google Scholar 

  29. Van Goudoever JB, Wattimena JLD, Carnielli VP, Sulkers EJ, Degenhart HJ, Sauer PJJ. (1994) Effect of dexamethasone on protein metabolism in infants with bronchopulmonary dysplasia. J Pediatr 124:112–118.

    Article  PubMed  Google Scholar 

  30. Silverman M. (1994) Chronic lung disease of prematurity: are we too cautious with steroids? Eur J Pediatr 153: S30–S35.

    Article  PubMed  CAS  Google Scholar 

  31. Bos AF, Reitsma-Bierens WWC, Okken A. (1994) Effects of dexamethasone treatment on diuresis, serum urea and arterial blood pressure in preterm infants with bronchopulmonary dysplasia. Pediatr Res 36:7A. (Abst).

    Google Scholar 

  32. Howard E. (1968) Reductions in size and total DNA of cerebrum and cerebellum in adult mice after corticosterone treatment in infancy. Exp Neurol 22:191–208.

    Article  PubMed  CAS  Google Scholar 

  33. Benesova O, Pavlik A. (1989) Perinatal treatment with glucocorticoids and the risk of maldevelopment of the brain. Neuropharmacology 28:89–97.

    Article  PubMed  CAS  Google Scholar 

  34. Tsuneishi S, Takada S, Motoike T, Ohashi T, Sano K, Nakamura H. (1991) Effects of dexamethasone on the expression of myelin basic protein, proteolipid protein, and glial fibrillary acidic protein genes in developing rat brain. Brain Res Dev Brain Res 61:117–123.

    Article  PubMed  CAS  Google Scholar 

  35. Zahalka EA, Seidler FJ, Slotkin TA. (1993) Dexamethasone treatment in uteroen hances neonatal cholinergic nerve terminal development in rat brain. Res Commun Chem Pathol Pharmacol 81:191–198.

    PubMed  CAS  Google Scholar 

  36. Howard E, Granoff DM. (1968) Increased voluntary running and decreased motor coordination in mice after neonatal corticosterone implantation. Exp Neurol 22:661–673.

    Article  PubMed  CAS  Google Scholar 

  37. Schapiro S. (1968) Some physiological, biochemical and behavioral consequences of neonatal hormone administration: Cortisol and thyroxin. Gen Comp Endocrinol 10:214–218.

    Article  PubMed  CAS  Google Scholar 

  38. Fujii T, Horinaka M, Hata M. (1993) Functional effects of glucocorticoid exposure during fetal life. Prog Neuro-psychopharmacol & Biol Psychiat 17:279–293.

    Article  CAS  Google Scholar 

  39. Barks JD, Post M, Tuor UI. (1991) Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat. Pediatr Res 29:558–563.

    Article  PubMed  CAS  Google Scholar 

  40. Raley-Susman KM, Sapolsky RM. (1994) Glucocorticoid effects on neuronal development and vitality. In: Lou HC, Greisen G, Falck Larsen J, eds. Brain lesions in the newborn. Munksgaard, Copenhagen, pp 257–271.

    Google Scholar 

  41. Bregman J, Farrell EE. (1992) Neurodevelopmental outcome in infants with bronchopulmonary dysplasia. Clin Perinatol 19:673–694.

    PubMed  CAS  Google Scholar 

  42. Mammel MC, Fiterman C, Coleman M, Boros SJ. (1987) Short-term dexamethasone therapy for bronchopulmonary dysplasia: acute effects and 1-year follow-up. Dev Pharmacol Ther 10:1–11.

    PubMed  CAS  Google Scholar 

  43. Satish M, Schwartz P, Urrutia J, Krishnan V, Basting C. (1991) Developmental outcome of dexamethasone treated infants. Pediatr Res 29:1564A. (Abst).

    Google Scholar 

  44. Gross SJ and Cummings J J. (1992) Four year follow-up of a controlled trial of dexamethasone (DEX) in ventilator dependent preterm infants. Pediatr Res 31:204A. (Abst).

    Google Scholar 

  45. Bos AF. (1993) Differential effects of brain lesions and systemic disease on the quality of general movements: a preliminary report. Early Hum Dev 34:39–45.

    Article  PubMed  CAS  Google Scholar 

  46. Prechtl HFR. (1990) Editorial: Qualitative changes of spontaneous movements in fetus and preterm infant are a marker of neurological dysfunction. Early Hum Dev 23:151–158.

    Article  PubMed  CAS  Google Scholar 

  47. Bos AF, van Asperen RM, Prechtl HFR, Okken A. (1994) Effects of dexamethasone treatment on spontaneous motor behaviour in preterm infants with bronchopulmonary dysplasia. Pediatr Res 36:7A. (Abst).

    Google Scholar 

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Authors
  1. A. F. Bos
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  2. S. Bambang Oetomo
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Editor information

Editors and Affiliations

  1. Dept. of Pediatric Surgery, Pediatric Surgical Intensive Care Unit, Sophia Children’s Hospital, University Hospital Rotterdam, Dr. Molewaterplein 60, NL-3015, GJ Rotterdam, The Netherlands

    Dick Tibboel

  2. Dept. of Pediatrics, Subdivision of Pediatric, Intensive Care, Sophia Children’s Hospital, University Hospital Rotterdam, Dr. Molewaterplein 60, NL-3015, GJ Rotterdam, The Netherlands

    Edwin van der Voort

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© 1996 Springer-Verlag Berlin Heidelberg

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Bos, A.F., Oetomo, S.B. (1996). Adverse Effects of Dexamethasone Treatment in Preterm Neonates. In: Tibboel, D., van der Voort, E. (eds) Intensive Care in Childhood. Update in Intensive Care and Emergency Medicine, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80227-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-80227-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80229-4

  • Online ISBN: 978-3-642-80227-0

  • eBook Packages: Springer Book Archive

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