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Regulation of Gut Oxygen Delivery, Cellular Oxygen Supply and Metabolic Activity

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Gut Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 26))

Abstract

Over the past three decades, a large number of studies have examined the physiological regulation of blood flow, oxygen supply (DO2) and oxygen extraction (O2ER) in the gut using a wide variety of different models and experimental approaches. More recently, with a growing recognition of the potential significance of gut dysfunction in critical illness, investigators have explored the behavior of the gut under pathophysiological conditions, in terms of its regulation of cellular O2 supply and epithelial barrier function. In this review, we begin with a brief overview of the physiological regulation of intestinal blood flow and oxygen transport, and then proceed to examine the potential significance of these findings for the function of the gut during critical illness, and especially during sepsis.

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Authors
  1. P. T. Schumacker
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Editors and Affiliations

  1. Department of Surgery, Pennsylvania University Hospital, 3400 Spruce Street, 19104, Philadelphia, PA, USA

    J. L. Rombeau

  2. Department of Intensive Care Critical Care Research Program, Kuopio University Hospital, FIN-70211, Kuopio, Finland

    J. Takala

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© 1996 Springer-Verlag Berlin Heidelberg

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Schumacker, P.T. (1996). Regulation of Gut Oxygen Delivery, Cellular Oxygen Supply and Metabolic Activity. In: Rombeau, J.L., Takala, J. (eds) Gut Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80224-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-80224-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80226-3

  • Online ISBN: 978-3-642-80224-9

  • eBook Packages: Springer Book Archive

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