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Yearbook of Intensive Care and Emergency Medicine pp 111–118Cite as

Potential Role for Human Interleukin-11 in Bacterial Sepsis

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

Abstract

Human interleukin (IL)-11 was first isolated and characterized by Paul and colleagues in 1990 [1] as one of the essential elements of the hematopoietic microenvironment. It was initially described as a hematopoietic growth factor from stromal bone marrow elements which could support the growth of a plasmacytoma cell line and had profound effects on megakaryocyte growth and development. It was subsequently shown that this is a remarkably pleiotropic cytokine with numerous physiologic attributes affecting hematopoietic and non-hematopoietic cell lines [2]. Recent experimental evidence indicates that IL-11 possesses therapeutic properties which may prove to be beneficial in the prevention and treatment of human sepsis. This chapter will summarize the current knowledge of this important cytokine and describe its potential therapeutic role in the septic patient.

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Authors
  1. S. M. Opal
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  2. J. C. Keith Jr.
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Opal, S.M., Keith, J.C. (1996). Potential Role for Human Interleukin-11 in Bacterial Sepsis. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60552-2

  • Online ISBN: 978-3-642-80053-5

  • eBook Packages: Springer Book Archive

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