Skip to main content
SpringerLink
Log in
Book cover

Biologic Rhythms in Clinical and Laboratory Medicine pp 418–427Cite as

Cardiovascular Chronobiology and Chronopharmacology

  • Chapter

Abstract

Circadian rhythms in the functions of the cardiovascular system are now well established (for reviews see [1–5]). Biological rhythms in heart rate and blood pressure were already described at the end of the eighteenth and during the nineteenth century by Falconer, Autenrieth, Knox, Wilhelm, Zadek, and others (for references see [4]). Following these early reports, numerous and more sophisticated studies have provided convincing evidence for circadian rhythms in heart rate and in blood pressure in both in healthy subjects and in patients suffering from cardiovascular diseases. The development and use of automatic, 24 h, blood pressure monitoring devices has greatly contributed to our present knowledge about circadian rhythms in the cardiovascular system.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Smolensky MH, Tatar SE, Bergmann SA, Losmann JG, Barnard CN, Dacso CC, Kraft IA (1976) Circadian rhythmic aspects of human cardiovascular function: a review by chronobiologic statistical methods. Chronobiologia 3: 337–371

    PubMed  CAS  Google Scholar 

  2. Lemmer B (1987) Cardiovascular medications. In: Kuem-merle HP, Hitzenberger G, Spitzy KH (eds) Klinische Phar-makologie. Landsberg, ecomed 4th edn, pp 1–14

    Google Scholar 

  3. Lemmer B (1989) Circadian variations in the effects of cardiovascular active drugs. In: von Arnim T, Maseri A (eds) Predisposing conditions for acute ischemic syndromes. Steinkopff, Darmstadt, pp 1–11

    Google Scholar 

  4. Lemmer B (1989) Temporal aspects of the effects of cardiovascular active drugs in humans. In: Lemmer B (ed) Chronopharmacology - Cellular and biochemical interactions. Dekker, New York, pp 525–541

    Google Scholar 

  5. Lemmer B (1989) Circadian rhythms in the cardiovascular system. In: Arendt J, Minors DS, Waterhouse JM (eds) Biological rhythms in clinical practice. Butterworth, London pp 51–70

    Google Scholar 

  6. Lemmer B, Scheidel B, Behne S (1991) Chronopharmaco-kinetics and chronopharmacodynamics of cardiovascular active drugs: propranolol, organic nitrates, nifedipine. Ann NY Acad Sci 618:166–181

    Article  PubMed  Google Scholar 

  7. Hossmann V, Fitzgerald GA, Dollery CT (1980) Circadian rhythm of baroreflex reactivity and adrenergic vascular response. Cardiovasc Res 14:125–129

    Article  PubMed  CAS  Google Scholar 

  8. Aronow WS, Harding PR, DeQuattro V, Isbell M (1973) Diurnal variation of plasma catecholamines and systolic time intervals. Chest 63: 722–726

    Article  PubMed  CAS  Google Scholar 

  9. Tuck ML, Stern N, Sowers JR (1985) Enhanced 24 h norepinephrine and renin secretion in young patients with essential hypertension: relation with the circadian pattern of arterial blood pressure. Am J Cardiol 55:112–115

    Article  PubMed  CAS  Google Scholar 

  10. Lemmer B (1988). Die Bedeutung der Chronopharmako-logie für die medikamentöse Therapie. Verh Dtsch Ges Inn Med 94: 420–430

    PubMed  CAS  Google Scholar 

  11. Lemmer B, Sailer R (1974) Influence of light and darkness on the turnover of noradrenaline in the rat heart. Naunyn Schmiedeberg’s Arch Pharmacol 282: 75–84

    Article  CAS  Google Scholar 

  12. Andreotti F, Davies GJ, Hackett DR, Khan MI, De Bart ACW, Aber VR, Maseri A, Kluft C (1988) Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden cardiac death and stroke. Am J Cardiol 62: 635–637

    Article  PubMed  CAS  Google Scholar 

  13. Lemmer B, Bärmeier H, Schmidt S, Lang PH (1987) On the daily variation in the beta-receptor - adenylate cyclase -cAMP - phosphodiesterase - system in rat forebrain. Chro-nobiol Int 4: 469–475

    CAS  Google Scholar 

  14. Lemmer B, Witte K (1989) Circadian rhythm of the in vitro stimulation of adenylate cyclase in rat heart tissue. Eur J Pharmacol 159: 311–315

    Article  PubMed  CAS  Google Scholar 

  15. Lemmer B, Wald C (1990) Influence of age on the rhythm in basal and forskolin-stimulated adenylate cyclase activity of the rat heart. Chronobiol Int 7:107–111

    Article  PubMed  CAS  Google Scholar 

  16. Lemmer B, Winkler H, Ohm T, Fink M (1985) Chronophar-macokinetics of beta-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, sotalol, atenolol) in plasma and tissues after single and multiple dosing in the rat. Naunyn Schmiedeberg’s Arch Pharmacol 330: 42–49

    Article  CAS  Google Scholar 

  17. Lemmer B, Bathe K, Lang PH, Neumann G, Winkler H (1983) Chronopharmacology of β-adrenoceptor blocking drugs: pharmacokinetics and pharmacodynamic studies in rats. J Am Coll Toxicol 2: 347–358

    Article  CAS  Google Scholar 

  18. Lemmer B, Bathe K (1982) Stereospecific and circadian-phase-dependent kinetic behaviour of d,l-, 1- and d-propra-nolol in plasma, heart and brain of light-dark-synchronized rats. J Cardiovasc Pharmacol 4: 635–644

    Article  PubMed  CAS  Google Scholar 

  19. Langner B, Lemmer B (1988) Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects. Eur J Clin Pharmacol 33: 619–624

    Article  PubMed  CAS  Google Scholar 

  20. Semenowizc-Siuda K, Markiewicz A, Korczynska-War-decka J (1984) Circadian bioavailability some effects of propranolol in healthy subjects and liver cirrhosis. Int J Clin Pharmacol Ther Toxicol 22: 653–658

    Google Scholar 

  21. Hla KK, Henry JA, Phull R, Volane QN, Latham AN (1988) Chronopharmacology of verapamil. 25th anniversary international symposium calcium antagonists in hypertension, Basel

    Google Scholar 

  22. Guillet P, Dubruc C, Bianchetti G, Thenot JP, Thebault JJ (1988) The pharmacokinetics of diltiazem vary according to its time of administration. Int Conf Pharmaceut Sci Clin Pharmacol, Jerusalem, Abstr p 55

    Google Scholar 

  23. Lemmer B, Behne S, Becker HJ (1989) Chronopharmacology of oral nifedipine in healthy subjects. Eur J Clin Pharmacol 36 (Suppl): A 177

    Google Scholar 

  24. Behne S, Becker HJ, Liefhold J, Lemmer B (1990) On the chronopharmacokinetics, effects on cardiovascular functions and plasma cAMP of oral nifedipine in healthy subjects. In: Lemmer B, Hüller H (eds) Clinical chronopharmacology, Klinische Pharmakologie/Clinical pharmacology vol 6. Zuckschwerdt, Munich 6: 49–63

    Google Scholar 

  25. Lemmer B, Nold G, Behne S, Becker HJ, Liefhold J, Kaiser R (1990) Chronopharmacology of oral nifedipine in healthy subjects and in hypertensive patients. Eur J Clin Pharmacol 183: 521

    Article  Google Scholar 

  26. Blankenstijn PJ, Wentig GJ, Schalekamp MADH (1989) 24 hour blood pressure profiles during ACE inhibition. A comparative study of twice daily captopril versus once daily enalapril. Int symp ACE inhibition, London, Abstr F 164

    Google Scholar 

  27. Boxho G (1988) Twenty-four-hour blood pressure recording during treatment with captopril twice daily. Curr Ther Res 44: 361–366

    Google Scholar 

  28. Meijer JL, Ardesch HG, van Rooijen JC, De Bruijn JHB (1987) Captopril plus hydrochlorothiazide once daily normalize 24 h blood pressure in patients with essential hypertension. Br J Clin Pharmacol 23: 83S-88S

    PubMed  Google Scholar 

  29. Raftery EB, Melville DI, Gould BA, Mann S, Whittington JR (1981) A study of the antihypertensive action of xipa-mide using ambulatory intra-arterial monitoring. Br J Clin Pharmacol 12: 381–385

    PubMed  CAS  Google Scholar 

  30. Palma JL, Isasa D, Senor J (1986) Ambulatory blood pressure monitoring in mild hypertension treated with pi-retanide. 2nd Int conf diuretics. Cascais, Portugal, Abstr p55

    Google Scholar 

  31. Bruguerolle B, Bouvenot G, Bartolin R, Manolis J (1988) Chronopharmacocinétique de la digoxine chez le sujet de plus de soixante-dix ans. Therapie 43: 251–253

    PubMed  CAS  Google Scholar 

  32. Joy M, Pollard CM, Nunan TO (1982) Diurnal variation in exercise in angina pectoris. Br Heart J 48:156–160

    Article  PubMed  CAS  Google Scholar 

  33. Willich SN, Pohjola-Sintonen S, Bhatia SJS, Shook TL, Toiler GH, Muller JE, Curtis DG, Williams GH, Stone PH (1989) Suppression of silent ischemia by metoprolol without alteration of morning increase of platelet aggregability in patients with stable coronary artery disease. Circulation 79: 557–565

    Article  PubMed  CAS  Google Scholar 

  34. Lemmer B, Scheidel B, Stenzhorn G, Blume H, Lenhard G, Grether D, Renczes J, Becker HJ (1989) Clinical chronopharmacology of oral nitrates. Z Kardiol 78: 61–63

    PubMed  Google Scholar 

  35. Scheidel B, Lenhard G, Blume H, Becker HJ, Lemmer B (1989) Chronopharmacology of isosorbide-5-mononitrate (immediate release, retard formulation) in healthy subjects. Eur J Clin Pharmacol 36 (Suppl): A 177

    Google Scholar 

  36. Lemmer B, Scheidel B, Blume H, Becker HJ (1991) Clinical chronopharmacology of oral sustained-release isosorbide-5-mononitrate in healthy subjects. Eur J Clin Pharmacol 40: 71–75

    Article  PubMed  CAS  Google Scholar 

  37. Lemmer B (1990) Chronopharmakologie antiischämisch wirksamer Arzneimittel. In: Rudolph W (ed) Therapie der koronaren Herzerkrankung - Aktuelle Aspekte. Springer, Berlin Heidelberg New York, pp 76–84

    Google Scholar 

  38. Waters DD, Miller DD, Bouchard A, Bosch X, Theroux P (1984) Circadian variation in variant angina. Am J Cardiol 54: 61–64

    Article  PubMed  CAS  Google Scholar 

  39. Araki H, Koiwaya Y, Nakagaki O, Nakamura M (1983) Diurnal distribution of ST-segment elevation and related arrhythmias in patients with variant angina: a study by ambulatory ECG monitoring. Circulation 67: 995–1000

    Article  PubMed  CAS  Google Scholar 

  40. Arnim von T, Hofling B, Schreiber M (1985) Characteristics of episodes of ST elevation or ST depression during ambulatory monitoring in patients subsequently undergoing coronary angiography. Br Heart J 54: 484–488

    Article  Google Scholar 

  41. Muller JE, Stone PH, Turin ZG, Rutherford JG, Czeisler CA, Parkers C, Poole WK, Passamani E, Roberts R, Robertson T, Sobel BE, Willerson JT, Braunwald E (1985) The milis study group: circadian variation in the frequency of onset of acute myocardial infarction. N Engl. J Med 313: 1315–1322

    Article  PubMed  CAS  Google Scholar 

  42. Marshall J (1977) Diurnal variation in occurrence of strokes. Stroke 8: 230–231

    Article  PubMed  CAS  Google Scholar 

  43. Mitler MM, Hajdukovic RM, Shafor R, Hahn PM, Kripke DF (1987) When people die. Cause of death versus time of death. Am J Med 82: 266–274

    Article  PubMed  CAS  Google Scholar 

  44. Lemmer B (1990) Recent advances in the chronopharmacology of cardiovascular diseases. In: Lemmer B, Hiiller H (eds) Clinical chronopharmacology. Klinische Pharmakologie/Clinical pharmacology, vol 6, Zuckschwerdt, Munich: 45–52

    Google Scholar 

Download references

Authors
  1. B. Lemmer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lemmer, B. (1992). Cardiovascular Chronobiology and Chronopharmacology. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78734-8_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation