Skip to main content
SpringerLink
Log in

Heat-Shock Proteins and Mycobacterial Antigens

  • Conference paper
Book cover Rheumatoid Arthritis

  • 183 Accesses

Abstract

Most autoimmune diseases in humans are known to be associated with certain HLA alleles. This means that genetic factors contribute to individual susceptibility and that at least some of these factors are encoded within or close to the major histocompatibility complex (MHC). In the case of rheumatological disorders, the association of HLA-B27 with ankylosing spondylitis is well-known and impressive. Of less biological impact, but certainly very significant, is the association of HLA-DR4 and HLA-DR1 with rheumatoid arthritis. Furthermore, evidence has been put forward that the same DR4 allele contributes to the development of arthritis in Lyme borreliosis [42].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrahamsen TG, Froland SS, Natvig JB (1978) In vitro stimulation of synovial fluid lymphocytes from rheumatoid arthritis and juvenile rheumatoid arthritis parents: dissociation between the response to antigens and polyclonal mitogens. Scan J Immunol 7:81–90

    Article  CAS  Google Scholar 

  2. Bahr GM, Rook GAW, Al-Saffar M, Van Embden JDA, Stanford JL, Behbehani K (1989) An analysis of antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. tuberculosis in rheumatoid arthritis. Clin Exp Immunol 74:211–215

    Google Scholar 

  3. Batisto JR, Smith RN, Bechman K, Sternlight M, Welles WL (1982) Susceptibility to adjuvant arthritis in DA and F344 rats. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex. Arthritis Rheum 25:1194–1200

    Article  Google Scholar 

  4. Brav EA, Hench PS (1934) Tuberculous rheumatism. J Bone Joint Surg 16:839–866

    Google Scholar 

  5. Bernstein RM (1989) Heat-shock proteins and arthritis. Brit J Rheum 28:369–373

    Article  CAS  Google Scholar 

  6. Berry Y, Willoughby DA, Giroud JP (1973) Evidence for an endogenous antigen in the adjuvant arthritic rat. J Pathol 3:229–238

    Article  Google Scholar 

  7. Billingham MEJ, Butler R, Colston MJ (1990) A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic. J Exp Med 171:339–344

    Article  CAS  PubMed  Google Scholar 

  8. Cohen IR, Holoshitz J, Van Eden W, Frenkel A (1985) Lines of T lymphocytes illuminate pathogenesis and affect therapy of experimental arthritis. Arthritis Rheum 28:841–845

    Article  CAS  PubMed  Google Scholar 

  9. Cohen IR (1986) Regulation of autoimmune disease: physiological and therapeutic. Immunol Rev 94:5–21

    Article  CAS  PubMed  Google Scholar 

  10. Cohen, IR (to be published) T cell vaccination and suppression of autoimmune disease. Prog Immunol 7:867–873

    Google Scholar 

  11. De Vries RPP, van Eden W, Ottenhoff THM (1987) HLA Class II immune response genes and products in leprosy. Prog Allergy 36:95–113

    Google Scholar 

  12. Ellis J (1987) Proteins as molecular chaperones. Cell 328:378–379

    CAS  Google Scholar 

  13. Evans D, Norton P, Ivanyi J (1990) Distribution in tissue sections of the human groEL stress-protein homologue. APMIS 98:437–441

    Article  CAS  PubMed  Google Scholar 

  14. Gaston JSH, Life PF, Bailey LC, Bacon PA (1989) In vitro responses to a 65 kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J Immunol 143:2494–2500

    CAS  PubMed  Google Scholar 

  15. Holmgren A, Branden C (1989) Crystal structure of chaperone protein PapD reveals an immunoglobulin fold. Nature 342:248–251

    Article  CAS  PubMed  Google Scholar 

  16. Holoshitz J, Naparstek V, Ben-Nun A, Cohen IR (1983) Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science 219:56–58

    Article  CAS  PubMed  Google Scholar 

  17. Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by clones of T lymphocytes responsiveness to mycobacteria but not to collagen type IL J Clin Invest 73:211–215

    Article  CAS  PubMed  Google Scholar 

  18. Holoshitz J, Koning F, Coligan JE, de Bruyn J, Strober S (1989) Isolation of CD4–CD8-mycobacteria reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226–229

    Article  CAS  PubMed  Google Scholar 

  19. Jindal S, Dudani AK, Harley CB, Singh B, Gupta RS (1989) Primary structure of a human mitochondrial protein homologous to bacterial and plant chaperonins and to 65 kD mycobacterial antigen. Mol Cell Biol 9:2279–2283

    CAS  PubMed  Google Scholar 

  20. Karlsson-Parra A, Soderstrom K, Ferm M, Ivanyi J, Kiessling R, Klareskog L (1990) Presence of human 65kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients. Scand J Immunol 31:283–291

    Article  CAS  PubMed  Google Scholar 

  21. Kaufmann SHE (1990) Heat shock proteins and the immune response. Immunol Today 11:129–136

    Article  CAS  PubMed  Google Scholar 

  22. Klein J (1986) The natural history of the major histocompatibility complex. Wiley, New York, p 648–658

    Google Scholar 

  23. Kohashi O, Kohashi Y, Takahashi T, Ozawa A, Shigematsu N (1986) Suppressive effect of E. coli on adjuvant induced arthritis in germ-free rats. Arthrit Rheum 29:547–555

    Article  CAS  Google Scholar 

  24. Lakomek H, Will H, Zech M, Krüskemper HL (1984) A new serologic marker in ankylosing spondylitis. Arth Rheum 27:961–967

    Article  CAS  Google Scholar 

  25. Lamb JR, Bal V, Mendez-Samperio P, Mehlert A, So A, Rothbard J, Jindal S, Young RA, Young DB (1989) Stress proteins may provide a link between the immune response to infection and autoimmunity. Int Immunol 1:191–196

    Article  CAS  PubMed  Google Scholar 

  26. Munk ME, Schoel B, Modrow S, Karr RW, Young RA, Kaufmann SHE (1989) T lymphocytes from healthy individuals with specificity to self epitopes shared by the mycobacterial and human 65 kDa heat shock protein. J Immunol 143:2844–2849

    CAS  PubMed  Google Scholar 

  27. Nagy ZA, Lehmann PV, Falcioni F, Muller S, Adorini L (1989) Why peptides? Their possible role in the evolution of MHC restricted T-cell recognition. Immunol Today 10:132–138

    Article  CAS  PubMed  Google Scholar 

  28. Ostermann J, Horwich AL, Neupert W, Hartl FU (1989) Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature 341:125–130

    Article  CAS  PubMed  Google Scholar 

  29. Ottenhoff THM, Torres P, De Las Aguas JT, Fernandez R, Van Eden W, De Vries RRP, Stanford JL (1986) Evidence for an HLA-DR4 associated immune response gene for Mycobacterium tuberculosis: a clue to the pathogenesis of rheumatoid arthritis. Lancet ii:310–312

    Article  Google Scholar 

  30. Ottenhoff THM, Birhane Kale AB, Van Embden JDA, Thole JER, Kiessling R (1988) The recombinant 65 kD heat-shock protein of M. bovis BCG is a target molecule for CD4 cytotoxic T lymphocytes that lyse human monocytes. J Exp Med 168:1947–1952

    Article  CAS  PubMed  Google Scholar 

  31. Palacios-Boix AA, Estrad GI, Colston MJ, Panayi GS (1988) HLA-DR4 restricted lymphocyte proliferation to a Mycobacterium tuberculosis extract in rheumatoid arthritis and healthy subjects. J Immunol 140:2–13

    Google Scholar 

  32. Pelham HRB (1989) Heat shock and the sorting of luminal ER proteins. EMBO J 8:3171–3176

    CAS  PubMed  Google Scholar 

  33. Pearson CM (1956) Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc Soc Exp Biol Med 91:95–101

    CAS  PubMed  Google Scholar 

  34. Pearson CM, Wood FD (1964) Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant: I. General clinical and pathologic characteristics and some modifying factors. Arthritis Rheum 2:440–459

    Article  Google Scholar 

  35. Piercy DWT (1971) Synovitis induced by killed Erysipelothrix rhusiopathiae. J Comp Path 81:557–562

    Article  CAS  PubMed  Google Scholar 

  36. Pope RM, Pahlavani MA, LaCour E, Sambol S, Desai BV (1989) Antigenic specificity of rheumatoid synovial fluid lymphocytes. Arthritis Rheum 32:1371–1380

    Article  CAS  PubMed  Google Scholar 

  37. Quagliata F, Phillips-Quagliata JM (1972) Competence of thoracic duct cells to the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for successful transfer of the disease. Cell Immunol 3:78–87

    Article  CAS  PubMed  Google Scholar 

  38. Reading DS, Hallberg RL, Myers AM (1989) Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor. Nature 337:655–659

    Article  CAS  PubMed  Google Scholar 

  39. Res PCM, Schaar CG, Breedveld FC, Van Eden W, Van Embden JDA, Cohen IR, De Vries RRP (1988) Synovial fluid T cell reactivity against the 65 kD heat-shock protein of mycobacteria in early onset of chronic arthritis. Lancet ii:478–482

    Article  Google Scholar 

  40. Shinnick TM, Vodkin MH, Williams JC (1988) The Mycobacterium tuberculosis 65 kD antigen is a heat-shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein. Infect Immun 56:446–451

    CAS  PubMed  Google Scholar 

  41. Steere AC, Malawista SE, Suydman DR, Shope RE, Andiman WA, Ross MR, Steele FM (1977) Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum 20:7–17

    Article  CAS  PubMed  Google Scholar 

  42. Thole JER, Dauwerse HG, Das PK, Groothuis DG, Schouls LM, Van Embden JDA (1985) Cloning of the Mycobacterium bovis BCG DNA and expression of antigens in Escherichia coli. Infect Immun 50:800–806

    CAS  PubMed  Google Scholar 

  43. Thole JER, Keulen WJ, Kolk AHJ, Groothuis DG, Berwald LG, Tiesjema RH, Van Embden JDA (1987) Characterization, sequence determination, and immunogenici-ty of a 64kD protein of M. bovis BCG expressed in E. coli K12. Infect Immun 55:1466–1475

    CAS  PubMed  Google Scholar 

  44. Thole JER, Hindersson P, De Bruyn J, Cremers F, Van der Zee J, De Cock H, Tommassen J, Van Eden W, Van Embden JDA (1988) Antigenic relatedness of a strongly immunogenic 65kD mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen. Microbiol Pathog 4:71–83

    Article  CAS  Google Scholar 

  45. Torisu M, Miyahara T, Shinohara N, Ohsato K, Sonozaki H (1978) A new side effect of BCG immunotherapy: BCG-induced arthritis in man. Cancer Immunol Immunother 5:77–83

    Article  Google Scholar 

  46. Van den Broek MF, Van Bruggen MCJ, Hogervorst EJM, Van Eden W, Van der Zee R, Van der Berg WB (1989) Protection against streptococcal cell wall induced arthritis by pretreatment with the mycobacterial 65kD heat-shock protein. J Exp Med 170:449–466

    Article  PubMed  Google Scholar 

  47. Van Eden W, de Vries RRP (1984) HLA and leprosy: a re-evaluation. Lep Rev 55:89–104

    Google Scholar 

  48. Van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR (1985) Arthritis induced by a T lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Nat Acad Sci USA 82:5064–5067

    Article  Google Scholar 

  49. Van Eden W, Holoshitz J, Cohen IR (1987) Antigenic mimicry between mycobacteria and cartilage proteoglycans: the model of adjuvant arthritis. In: Cruse TM (ed) Concepts Immunopathol, 4th edn. Karger, Basel, pp 144–170

    Google Scholar 

  50. Van Eden W, Thole JER, van der Zee R, Noordzij A, van Embden JDA, Hensen EJ, Cohen IR (1988) Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331:171–173

    Article  PubMed  Google Scholar 

  51. Van Eden W, Hogervorst EJM, Hensen EJ, Van der Zee R, Van Embden JDA, Cohen IR (1989) A cartilage mimicking T cell epitope on a 65kD mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis. In: Oldstone MB (ed) cross-reactivity between microbes and host proteins as a cause of autoimmunity. Curr Top Microbiol Immunol 145:27–43 Springer, Heidelberg New York

    Google Scholar 

  52. Van Eden W, Boog CJP, Hogervorst EJM, Wauben MH, van der Zee R, van Embden JDA (1991) A mycobacterial heat-shock protein T cells in experimental arthritis: possibilities for immunotherapy. In: Kresina T (ed) Monoclonal antibodies and immunotherapy of rheumatoid arthritis. Marcel Dekker, New York, pp 253–268

    Google Scholar 

  53. Van der Zee R, Van Eden W, Meloen RH, Noordzij A, Van Embden JDA (1989) Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides. Eur J Immunol 19:43–47

    Article  PubMed  Google Scholar 

  54. Vodkin MH, Williams JC (1988) A heat shock Operon in Coxiella burnetii produces a major antigen homologous to a protein in both mycobacteria and Escherichia coli. J Bacteriol 170:1227–34

    CAS  PubMed  Google Scholar 

  55. Young DB, Ivanyi J, Cox JH, Lamb JR (1987) The 65kDa antigen of mycobacteria — a common bacterial protein? Immunol Today 8:215–219

    Article  CAS  Google Scholar 

  56. Winfield JB (1990) Stress proteins, arthritis, and autoimmunity. Arthritis Rheum 32:1497–1504

    Article  Google Scholar 

  57. Danieli MG, Markovitz D, Gabrielli A, Corvetta A, Giorgi PL, van der Zee R, van Embden JDA, Danieli G, Cohen IR (1991) Juvenile Rheumatoid Arthritis patients manifest immune reactivity to the mycobacterial 65 kd heat shock protein, to its 180–188 peptide and to a partially homologous peptide of the proteoglycan link protein. J Clin Invest (submitted)

    Google Scholar 

  58. De Graeff-Meeder ER, van der Zee R, Rijkers GT, Schuurman HJ, Bijlsma JWJ, Kuis W, Zegers BJM, van Eden W (1991) Recognition of human 60kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis. Lancet 337:1368–1372

    Article  PubMed  Google Scholar 

  59. Emmrich F, Thole J, van Embden J, Kaufmann SHE (1986) A recombinant 64 kilodalton protein of Mycobacterium bovis Bacillus Calmette-Guerin specificially stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med 163:1024–1029

    Article  CAS  PubMed  Google Scholar 

  60. Hemmingsen SM, Woolford C, van der Vies SM, Tilly K, Dennis DT, Georgopoulos CP, Hendrix RW, Ellis RJ (1988) Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Nature 333:330–334

    Article  CAS  PubMed  Google Scholar 

  61. Hogervorst EJM, Boog CJP, Wagenaar JPA, Wauben MHM, van der Zee R, van Eden W (1991) T cell reactivity to an epitope of the mycobacterial 65-kDa heat shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65 specific cellular responses. Eur J Immunol 21:1289–1296

    Article  CAS  PubMed  Google Scholar 

  62. Kaufmann SHE, Väth U, Thole JER, van Embden JDA, Emmrich F (1987) Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64 kilodalton protein. Eur J Immunol 17:351–357

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Infectious Diseases & Immunology, Veterinary Faculty, University of Utrecht, P. O. Box 80.165, 3508 TD, Utrecht, The Netherlands

    W. van Eden, C. J. P. Boog, E. J. M. Hogervorst & M. H. M. Wauben

  2. Department of Bacteriology, National Institute of Public Health and Environmental Hygiene, P. O. Box 1, 3720 BA, Bilthoven, The Netherlands

    W. van Eden, R. van der Zee & J. D. A. van Embden

Authors
  1. W. van Eden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. J. P. Boog
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. J. M. Hogervorst
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. H. M. Wauben
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. van der Zee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. D. A. van Embden
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

van Eden, W., Boog, C.J.P., Hogervorst, E.J.M., Wauben, M.H.M., van der Zee, R., van Embden, J.D.A. (1992). Heat-Shock Proteins and Mycobacterial Antigens. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76189-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76191-1

  • Online ISBN: 978-3-642-76189-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation