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The Role of Alveolar and Intravascular Macrophages in Acute Lung Injury: New Methods and New Mechanisms

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New Aspects on Respiratory Failure

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Abstract

Resident macrophages are central in defending the lungs against the assaults of particles and pathogens in inspired air. The phagocytic and microbicidal potential of macrophages is one of the major reasons why the lungs remain clean and sterile. Macrophages may also prevent allergy by ingesting and catabolizing inhaled foreign proteins. Alternatively, during some lung infections they may preserve and present antigens to lymphocytes and act cooperatively with other components of the immune system to enhance the immune response. At other times lung macrophages recognize and destroy neoplastic cells, thus preventing the development of cancer. Alveolar macrophages may also ingest effete type 1 and type 2 epithelial cells, red blood cells, and perhaps even some of the “worn out” surfactant (Brain 1985).

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Authors
  1. J. D. Brain
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  2. A. E. Warner
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Editors and Affiliations

  1. Institut für Anaesthesiologie, Universität Erlangen-Nürnberg, Krankenhausstrasse 12, D-8520, Erlangen, Germany

    Erich Rügheimer

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© 1992 Springer-Verlag Berlin Heidelberg

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Brain, J.D., Warner, A.E. (1992). The Role of Alveolar and Intravascular Macrophages in Acute Lung Injury: New Methods and New Mechanisms. In: Rügheimer, E. (eds) New Aspects on Respiratory Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74943-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-74943-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74945-2

  • Online ISBN: 978-3-642-74943-8

  • eBook Packages: Springer Book Archive

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