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Signal Transduction and Antiproliferative Function of the Mammalian Receptor for Type 3 Reovirus

  • Chapter
Reoviruses I

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/1))

Abstract

Viruses exploit cellular proteins or membrane components as receptors or docking sites for binding and infection (reviewed in Saragovi et al. 1992a; Sauvé et al. 1992). A small list includes mammalian molecules such as epidermal growth factor receptors (EGFR), C3d receptors, CD4, EPO receptors, CD46, and interleukin (IL)-2 p75(β) receptors (Blomquist et al. 1984; Klatzmann et al. 1984; Frade et al. 1985; Li et al. 1990). These mammalian cell surface molecules have well-known physiological functions, and their role as viral docking sites is pathological.

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References

  • Blomquist MC, Hunt L, Barker W (1984) Vaccinia virus 19 kilodalton protein: relationship to several mammalian proteins, including two growth factors. Proc Natl Acad Sci USA 81:7363–7367

    Article  PubMed  CAS  Google Scholar 

  • Boguski MS, McCormick F (1993) Proteins regulating ras and its relatives. Nature 366:643–653

    Article  PubMed  CAS  Google Scholar 

  • Bruck C, Co MS, Slaoui M, Gaulton G, Smith T, Mullins J, Fields B, Greene MI (1986) Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to that of the external antigen. Proc Natl Acad Sci USA 83: 6578–6582

    Article  PubMed  CAS  Google Scholar 

  • Co M, Gaulton G, Fields B, Greene MI (1985a) Isolation and characterization of the reovirus hemagglutinin receptors. Proc Natl Acad Sci USA 82: 1494–1498

    Article  PubMed  CAS  Google Scholar 

  • Co M, Gaulton G, Fields B, Homcy M, Greene MI (1985b) Structural similarities of the reovirus and beta adrenergic receptors. Proc Natl Acad Sci USA 82: 5315–5318

    Article  PubMed  CAS  Google Scholar 

  • Cohen JA, Williams WV, Weiner DB, Greene MI (1990a) Antigenic and structural features of reoviruses. Imnnmochem Viruses 2: 381–402

    Google Scholar 

  • Cohen JA, Williams WV, Weiner DB, Geller HM, Greene MI (1990b) Ligand binding to the cell-surface receptor for reovirus type 3 stimulates galactocerebroside expression by developing oligodendrocytes. Proc Natl Acad Sci USA 87: 4922–4926

    Article  PubMed  CAS  Google Scholar 

  • Cook SJ, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262: 1069–1072

    Article  PubMed  CAS  Google Scholar 

  • Dichter MA, Weiner HL, Fields BN, Mitchell G, Noseworthy J, Gaulton GN, Greene MI (1986) Antiidiotypic antibody to reovirus binds to neurons and protects from viral infection. Ann Neurol 19: 555–558

    Article  PubMed  CAS  Google Scholar 

  • Dym M, Clermont Y (1970) Role of spermatogonia in the repair of the seminiferous epithelium following x-irradiation of the rat testis. Am J Anat 128: 265–282

    Article  PubMed  CAS  Google Scholar 

  • Ertl H, Greene MI, Noseworthy J, Fields B, Nepom J, Spriggs D, Finberg E (1982) Identification of idiotypic receptors on reovirus specific cytolytic T cells. Proc Natl Acad Sci USA 79: 7479–7483

    Article  PubMed  CAS  Google Scholar 

  • Gaulton GN, Greene MI (1989) Inhibition of cellular DNA synthesis by reovirus occurs by a reovirus receptor linked signalling pathway which is mimicked by anti-receptor antibody. J Exp Med 169: 197–212

    Article  PubMed  CAS  Google Scholar 

  • Gentsch J, Pacitti A (1985) Effect of neuraminidase treatment of cells and effect of soluble glycoproteins on type 3 Reovirus attachment of murine L cells. J Virol 56: 356

    PubMed  CAS  Google Scholar 

  • Greene MI, Kokai Y, Gaulton GN, Powell MB, Geller H, Cohen J (1987) Receptor systems in tissues of the nervous system. Immunol Rev 100: 153–184

    Article  PubMed  CAS  Google Scholar 

  • Kauffman R, Noseworthy J, Nepom J, Finberg R, Fields B, Greene MI (1983) Cell receptors for the mammalian reovirus. II. Monoclonal anti-idiotypic antibody blocks viral binding to cells. J Immunol 131: 2539–2541

    PubMed  CAS  Google Scholar 

  • Kilham L, Margolis G (1969) Hydrocephalus in hamsters, ferrets, rats and mice following inoculations with reovirus type 1. II. Pathologic studies. Lab Invest 21: 189–198

    PubMed  Google Scholar 

  • Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman JC, Montagnier L (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312: 767–768

    Article  PubMed  CAS  Google Scholar 

  • Lazaris-Karatzas A, Smith MR, Frederickson RM, Jaramillo ML, Liu Y-1, Kung H-F, Sonenberg N (1992) Ras-mediates translation initiation factor 4E-induced malignant transformation. Genes Dev 6 (9): 1631–1642

    Article  PubMed  CAS  Google Scholar 

  • Lee PW, Hayes EC, Jolik WK (1981) Protein sigma 1 is the reovirus cell attachment protein. Virology 108: 156–163

    Article  PubMed  CAS  Google Scholar 

  • Li J-P, D’Andrea AD, Lodish HF, Baltimore D (1990) Activation of cell growth by binding of FriendSpleen-focus forming virus gp55 glycoprotein to the erytrhopoietin receptor. Nature 343: 762–764

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Co M, Greene MI (1988) Reovirus type 3 and [1125] iodocyanopindalol bind to distinct domains of the reovirus receptor. Immunol Res 7: 232–238

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Casillas F, Wrana JL, Massague J (1993) Betaglycan presents ligand to the TGF beta signaling receptor. Cell 73: 1435–1444

    Article  PubMed  CAS  Google Scholar 

  • Masri SA, Nagata L, Mah DCW, Lee PWK (1986) Functional expression in Escherichia coli of cloned reovirus SI gene encoding the viral cell attachment protein s-1. Virology 149: 83–90

    Article  PubMed  CAS  Google Scholar 

  • Massague J, Weinberg RA (1992a) Negative regulators of growth. Curr Opin Genet Dev 2:28–32 Massague J (1992b) Receptors for the TGF-beta family. Cell 69: 1067–1070

    CAS  Google Scholar 

  • Matsumoto AM (1996) Spermatogenesis. In: Adashi EY, Rock JA, Rosenwaks Z (eds) Reproductive endocrinology, surgery and technology, vol I. Lippincott-Raven, Philadelphia, pp 359–384

    Google Scholar 

  • Matsuzaki N, Hinshaw V, Fields B, Greene MI (1986) Cell receptors for the mammalian reovirus: reovirus-specific T-cell hybridomas can become persistently infected and undergo autoimmune stimulation. J Virol 60: 259

    PubMed  CAS  Google Scholar 

  • Nepom J, Weiner HL, Dichter MA, Fields BN, Greene MI (1982) Identification of a hemagglutinin specific idiotype associated with reovirus recognition shared by lymphoid and neuronal cells. J Exp Med 155: 155–167

    Article  PubMed  CAS  Google Scholar 

  • Noseworthy J, Fields B, Dichter M, Sobotka C, Pizer E, Perry L, Nepom J, Greene MI (1983) Cell receptors for the mammalian reovirus. I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus. J Immunol 131: 2533–2538

    PubMed  CAS  Google Scholar 

  • Pacitti A, Gentsch J (1987) Inhibition of reovirus type 3 binding to host cells by sialylated glycoproteins is mediated through the viral attachment protein. J Virol 61: 1407–1415

    PubMed  CAS  Google Scholar 

  • Paul RW, Lee PKW (1987) Glycophorin is the reovirus receptor on human erythrocytes. Virology 159: 94–101

    Article  PubMed  CAS  Google Scholar 

  • Rebai N, Almazan G, Wei L, Greene M, Saragovi HU (1996) A p65/p95 neural receptor expressed at the S-G2 phase of the cell cycle subserves reovirus binding and defines distinct populations. Eur J Neurosci 8: 273–281

    Article  PubMed  CAS  Google Scholar 

  • Roux E, Robaire B, Saragovi HU (in press) A cell cycle regulating receptor is localized on the cell surface and in the nuclei of mitotically and meiotically dividing cells

    Google Scholar 

  • Saragovi HU, Fitzpatrick D, Raktabutr A, Nakanishi H, Kahn M, Greene MI (1991) Design and synthesis of a mimetic of an antibody complementarity determining region. Science 253: 792–795

    Article  PubMed  CAS  Google Scholar 

  • Saragovi HU, Sauvé GJ, Greene MI (1992a) Viral receptors. In: Webster RG, Granoff A (eds) Encyclopedia of virology. Saunders, London

    Google Scholar 

  • Saragovi HU, Chrusciel RA, Greene MI, Kahn M (1992b) Loops and secondary structure mimetics: development and applications in basic science and drug design. Biotechnology 10: 773–778

    Article  PubMed  CAS  Google Scholar 

  • Saragovi HU, Bhandoola A, Lemercier M, Akbar GKW, Greene MI (1995) A novel tyrosine kinase receptor subserves reovirus binding and regulates lymphocyte proliferation. DNA Cell Biol 14: 653–664

    Article  PubMed  CAS  Google Scholar 

  • Sauvé GJ, Saragovi HU, Greene MI (1992) Reovirus receptors. Adv Virus Res 42: 325–341

    Article  Google Scholar 

  • Schweitzer R, Howes R, Smith R, Ben-Zion S, Freeman M (1995) Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376: 699–701

    Article  PubMed  CAS  Google Scholar 

  • Sharpe A, Gaulton G, McDade K, Fields B. Greene MI (1984) Syngeneic monoclonal anti-idiotype can induce cellular immunity to reovirus. J Exp Med 160: 1195–1205

    CAS  Google Scholar 

  • Siegel RM, Katsumata M, Komori S, Wadsworth S, Gill-Morse L, Jerrold-Jones S, Bhandoola A, Greene MI, Yui K (1990) Mechanisms of autoimmunity in the context of T cell tolerance. Immunol Rev 118: 165–192

    Article  PubMed  CAS  Google Scholar 

  • Strong JE, Tang D, Lee PWK (1993) Evidence that the epidermal growth factor receptor on host cells confers reovirus infection efficiency. Virology 197: 405–411

    Article  PubMed  CAS  Google Scholar 

  • Szyf M, Theberge J, Bozovic V (1995) Ras induces a general DNA methylation activity in mouse embryonal PI9 cells. J Biol Chem 270: 12690–12696

    Article  PubMed  CAS  Google Scholar 

  • Tang D, Strong JE, Lee PWK (1993) Recognition of the epidermal growth factor receptor by reovirus. Virology 197: 412–414

    Article  PubMed  CAS  Google Scholar 

  • Tardieu M, Epstein R, Weiner H (1982) Interaction of viruses with cell surface receptors. Int Rev Cytol 80: 27–61

    Article  PubMed  CAS  Google Scholar 

  • Tyler KL, Fields BN (1990) Reoviridae and reoviruses. In: Second ED, Fields BN, Knipe DM et al. (eds) Virology. Raven, New York

    Google Scholar 

  • Ullman KS, Northrop JP, Verweij CL, Crabtree G (1990) Transmission of signals from the T lymphocyte antigen receptor. The missing link. Annu Rev Immunol 8: 421–452

    Article  PubMed  CAS  Google Scholar 

  • Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203–212

    Article  PubMed  CAS  Google Scholar 

  • Wang QM, Fiol CJ, DePaoli-Roach AA, Roach PJ (1994) Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. J Biol Chem 269: 14566–14574

    PubMed  CAS  Google Scholar 

  • Williams WV, Guy HR, Rubin DH, Robey F, Myers JN, Emmons TK, Weiner DB, Greene MI (1988) Sequences of the cell-attachment sites of reovirus type 3 and its anti-idiotypic/antireceptor antibody: modeling of their three-dimensional structures. Proc Natl Acad Sci USA 85: 6488–6492

    Article  PubMed  CAS  Google Scholar 

  • Williams WV, Moss DA, Kieber-Emmons T, Cohen J, Myers J, Weiner D. Greene MI (1989) Development of biologically active peptides based on antibody structure. Proc Natl Acad Sci USA 86: 5537–5541

    Article  PubMed  CAS  Google Scholar 

  • Zheng CF, Guan KL (1994) Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J 13: 1123–1131

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Montreal, QC, Canada, H3G 1Y6

    H. U. Saragovi, N. Rebai, E. Roux, M. Gagnon & B. Robaire

  2. McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, QC, Canada, H3G 1Y6

    H. U. Saragovi

  3. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 252 John Morgan Building, Philadelphia, PA, 19104-6082, USA

    X. Zhang & M. I. Greene

  4. Department of Transplant Surgery, University of Michigan Medical Center, 2926 Taubman Center, Box 0331, Ann Arbor, MI, 48109-0331, USA

    J. Bromberg

Authors
  1. H. U. Saragovi
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  2. N. Rebai
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  3. E. Roux
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  4. M. Gagnon
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  5. X. Zhang
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  6. B. Robaire
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  7. J. Bromberg
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  8. M. I. Greene
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box B-182, 80262, Denver, CO, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Saragovi, H.U. et al. (1998). Signal Transduction and Antiproliferative Function of the Mammalian Receptor for Type 3 Reovirus. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses I. Current Topics in Microbiology and Immunology, vol 233/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72092-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-72092-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72094-9

  • Online ISBN: 978-3-642-72092-5

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