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Systemic Lupus Erythematosus pp 105–123Cite as

ANA Subsets in Systemic Lupus Erythematosus

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Abstract

Antinuclear antibody (ANA) is a hallmark of systemic lupus erythematosus (SLE), being almost invariably detected in the sera of active untreated SLE patients. The recent history of research in the serology of SLE is marked by the resolution of the heterogeneous group of antigen-antibody reactions characteristic of these patients into individual antigen-antibody systems. This has involved purification and biochemical characterization of the reactive antigens of several of the frequently occuring nuclear targets of autoimmune attack in these patients. The detection and analysis of unfractionated ANA as well as antibodies to the two forms of DNA [native or double-stranded (ds) and denatured or single-stranded (ss)] will not be discussed in this chapter as they have been adequately described in other publications [1, 2].

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  1. M. Reichlin
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  2. J. B. Harley
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Reichlin, M., Harley, J.B. (1987). ANA Subsets in Systemic Lupus Erythematosus. In: Systemic Lupus Erythematosus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71642-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-71642-3_8

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