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The Molecular Biology of Adenoviruses 1 pp 75–87Cite as

The Origin of Adenovirus DNA Replication

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 109))

Abstract

Current efforts to understand regulation of replication and cell growth often focus on initiation of DNA replication at an origin sequence. It is most likely, although not yet proven in eukaryotes, that the ultimate step in the regulation of the G to S transition in the cell cycle is the priming of DNA synthesis at an origin. The study of this process in eukaryotic cells has progressed slowly, and most of the attention has centered upon the replication of virus DNAs in infected cells. Although this provides practical advantages, it may be limited in its generality since viral DNAs replicate many times throughout the course of an infection, disregarding the constraints normally placed upon chromosome replication. Nevertheless, an understanding of the mechanism of initiation in eukaryotes is necessary, and the availability of virus origins dictates that they be studied first.

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Author information

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, P.O Box 100, Cold Spring Harbor, NY, 11724, USA

    Fuyuhiko Tamanoi & Bruce W. Stillman

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  1. Fuyuhiko Tamanoi
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  2. Bruce W. Stillman
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Editors and Affiliations

  1. Institut für Genetik, Universität zu Köln, Weyertal 121, D-5000, Köln 41, Germany

    Walter Doerfler

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© 1983 Springer-Verlag Berlin Heidelberg

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Tamanoi, F., Stillman, B.W. (1983). The Origin of Adenovirus DNA Replication. In: Doerfler, W. (eds) The Molecular Biology of Adenoviruses 1. Current Topics in Microbiology and Immunology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69460-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-69460-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69462-2

  • Online ISBN: 978-3-642-69460-8

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