Abstract
In the last ten years focal segmental glomerulosclerosis (FSGS) has stimulated the interest of many pediatric nephrologists as a main glomerular lesion associated with the idiopathic nephrotic syndrome (NS) leading to chronic renal failure (CRF) (1, 3–7, 12, 14–16). The question is still debated if in the idiopathic NS FSGS belongs to the same disease entity as the minimal change glomerular lesions (MC). Furthermore, FSGS seems to be associated with many different clinical conditions, not only to the idiopathic NS, but also to well characterized disorders such as Alport’s syndrome, oligomeganephronic hypoplasia and cystinosis (3, 5). Some authors have therefore concluded that FSGS represents an unspecific histologic alteration without any major clinical significance.
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Schärer, K., Waldherr, R., Müller-Wiefel, D.E., Manz, F., Lenhard, V., Mehls, O. (1982). Idiopathic Nephrotic Syndrome Associated with Focal Segmental Glomerulosclerosis. In: Bulla, M. (eds) Renal Insufficiency in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68144-8_3
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DOI: https://doi.org/10.1007/978-3-642-68144-8_3
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