Conformation of Biological Molecules

Volume 20 of the series NMR Basic Principles and Progress pp 1-17

General Theory

  • Girjesh GovilAffiliated withTata Institute of Fundamental Research
  • , Ramakrishna V. HosurAffiliated withTata Institute of Fundamental Research

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The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating, field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc.) and theoretical methods (quantum mechanical and classical potential energy calculations, Monte-Carlo simulations and molecular graphics).