Skip to main content
SpringerLink
Log in

Lu-ECAM-1 and DPP IV in Lung Metastasis

  • Chapter
Attempts to Understand Metastasis Formation I

Part of the book series: Current Topics in Microbiology 213/I and Immunology ((CT MICROBIOLOGY,volume 213/1))

  • 101 Accesses

Abstract

The development of the metastatic cell is a Darwinian process involving random genetic changes and selection over many generations of tumor growth. Early events include a loosening of cell-cycle control and disabling of checkpoints and failsafe mechanisms such as cell-cell constraints on proliferation and motility (Rustgi et al. 1992; Fearson and Vogelstein 1990). Successfully metastatic cells arising from this population display an altered repertoire of cell adhesion molecules, allowing escape from the primary tumor, adhesion and penetration of the extracellular matrix (ECM) and entry into the microvasculature (Nicholson 1988; Fidler 1990; Hart and Saini 1992; Lafrenie et al. 1993). Most such cells are destroyed by geometric and hemodynamic forces in their first encounter with the narrow bore capillary net, usually in the lungs (Weiss et al. 1988). The few survivors may give rise to secondary colonies. The frequency of metastasis to the lungs has often been attributed solely to mechanical entrapment of tumor cell emboli. However, this theory does not explain the early observation that certain. tumor cell types prefer to metastasize to specific target organs. This behaviour was first noticed by Stephen Paget in 1889. He observed that breast carcinomas had very specific organ preferences for metastasis, and those preferences were not obviously related to circulatory patterns. About 70% of the patients had metastases to the liver, 20% to lungs, and only 10% to a few other organs. These observations inspired the “seed and soil” hypothesis which postulates that metastatic tumor cells are potentially unlimited in distribution but can only find purchase and prosper in a congenial soil.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguirre KM, McCormick RJ, Schwarzbauer JE (1994) Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecules. J Biol Chem 269: 27863–27868.

    PubMed  CAS  Google Scholar 

  • Albelda SM (1991) Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol 4: 193–203.

    Google Scholar 

  • Albelda SM (1993) Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 68: 4–17.

    PubMed  CAS  Google Scholar 

  • Alby L, Auerbach R (1984) Differential adhesion of tumor cells to capillary endothelial cells in vitro. Proc Natl Acad Sci USA 81: 5739–5743.

    Article  PubMed  CAS  Google Scholar 

  • Auerbach R, Lu WC, Pardon E, Gumkowski F, Kaminska G, Kaminska M (1987) Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo. Cancer Res.47: 1492–1496.

    PubMed  CAS  Google Scholar 

  • Augustin-Voss HG, Johnson RC, Pauli BU (1991) Modulation of endothelial cell surface glycoconjugate expression by organ-derived biomatrices. Exp Cell Res 192: 346–351.

    Article  PubMed  CAS  Google Scholar 

  • Banks RE, Gearing AJ, Hemingway IK, Norfolk DR, Perren TJ, Selby PJ (1993) Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies. Br J Cancer 68: 122–124.

    Article  PubMed  CAS  Google Scholar 

  • Belloni PN, Nicolson GL (1988) Differential expression of cell surface glycoproteins on various organ-derived microvascular endothelia and endothelial cell cultures. J Cell Physiol 136: 398–410.

    Article  PubMed  CAS  Google Scholar 

  • Belloni PN, Tressler RJ (1990) Microvascular endothelial cell heterogeneity: interactions with leukocytes and tumor cells. Cancer Metastasis Rev 8: 353–389.

    Article  PubMed  CAS  Google Scholar 

  • Bevilacqua MP (1993) Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 11: 767–894.

    Article  PubMed  CAS  Google Scholar 

  • Bevilacqua MP, Nelson RM (1993) Selectins. J Clin Invest 91: 379–387.

    Article  PubMed  CAS  Google Scholar 

  • Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B (1989) Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243: 1160–1165.

    Article  PubMed  CAS  Google Scholar 

  • Borsum T, Hagan T, Henrickson T, Hagan I, Henriksen T, Carlander B (1982) Alterations in the protein composition and surface structure of human endothelial cells during growth in primary culture. Atherosclerosis 44: 367–378.

    Article  PubMed  CAS  Google Scholar 

  • Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033–1037.

    Article  PubMed  CAS  Google Scholar 

  • Butcher EC, Scollay RG, Weissman IL (1979) Lymphocyte adherence to high endothelial venules: characteristics of a modified in vitro assay and examination of the binding of syngeneic and allogeneic lymphocyte populations. J Immunol 123: 1996–2003.

    PubMed  CAS  Google Scholar 

  • Chackal-Roy M, Niemeyer C, Moore M, Zetter BR (1989) Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow. J Clin Invest 84: 43–50.

    Article  PubMed  CAS  Google Scholar 

  • Couldwell WT, de Tribolet N, Antel JP, Gauthier T, Kuppner MC (1992) Adhesion molecules and malignant gliomas: implications for tumorigenesis. J Neurosurg 76: 782–791.

    Article  PubMed  CAS  Google Scholar 

  • Damjanovich L, Albelda SM, Mette SA, Buck CA (992) Distribution of Integrin cell adhesion receptors in normal and malignant lung tissue. Am J Respir Cell Mol Biol 6: 197–206.

    Google Scholar 

  • De Bono DT, Green C (1984) The adhesion of different cell types to vascular endothelium: effects of culture density and age. Br J Exp Pathol 65: 145–154.

    PubMed  Google Scholar 

  • Dejana E, Martin-Padura I, Lauri D, Bernasconi S, Bani MR, Garofalo A, Giavazzi R, Magnani J, Mantovani A, Menard S (1992) Endothelial leukocyte adhesion molecule-1-dependent adhesion of colon carcinoma cells to vascular endothelium is inhibited by an antibody to Lewis fucosylated type I carbohydrate chain. Lab Invest 66: 324–330.

    PubMed  CAS  Google Scholar 

  • Drickamer K (1987) Membrane receptors that mediate glycoprotein endocytosis: structure and biosynthesis. Kidney Int 32: S167–S180.

    CAS  Google Scholar 

  • Drickamer K (1988) Two distinct classes of carbohydrate-recognition domains in animal lectins. J Biol Chem 263: 9557–9560.

    PubMed  CAS  Google Scholar 

  • Elble RC, Widom J, Cheng CF, Levine RA, Pauli BU (1993) A lung-specific endothelial cell adhesion molecule mediates lung metastasis of murine melanomas. Mol Biol Cell 4: 217a.

    Google Scholar 

  • El-Sabban ME (1993) The role of endothelial cell-tumor cell interaction in tumor metastasis. Ph D dissertation, Cornell University.

    Google Scholar 

  • El-Sabban ME, Pauli BU (1991) Cytoplasmic dye transfer between metastatic tumor cells and vascular endothelium. J Cell Biol 115: 1375–1382.

    Article  PubMed  CAS  Google Scholar 

  • Fearson ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759–767.

    Article  Google Scholar 

  • Fidler IJ (1990) Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 50: 6130–6138.

    PubMed  CAS  Google Scholar 

  • Goetz DJ, El-Sabban ME, Hammer DA, Pauli BU (1995) Lu-EAM-1 mediated adhesion of melanoma ceils to endothelium under conditions of flow. Int J Cancer (in press).

    Google Scholar 

  • Goetz DJ, Hammer DA (1994) Dynamics of neutrophil rolling over stimulated endothelium in vitro. Biophys J 66: 2202–2209.

    Article  PubMed  CAS  Google Scholar 

  • Harning R, Ainolfi E, Bystryn J-C, Henn M, Merluzzi VJ, Rothlein R (1991) Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma. Cancer Res 51: 5003–5005.

    PubMed  CAS  Google Scholar 

  • Hart IR, Saini A (1992) Biology of tumor metastasis. Lancet 339: 1453–1457.

    Article  PubMed  CAS  Google Scholar 

  • Hartel S, Gossrau R, Hanski C, Reutter W (1988) Dipeptidyl peptidase IV (DPP IV) in rat organs: comparison of immunohistochemistry and activity histochemistry. Histochemistry 89: 151–162.

    Article  PubMed  CAS  Google Scholar 

  • Honn KV, Tang DG, Grossi I, Duniec ZM, Timar J, Renaud C, Leithauser M, Blair I, Diglio CA, Taylor JD, Marnett LJ (1993) Tumor cell-derived 12(S) HETE induces microvascular endothelial cell retraction. Cancer Res 53: 3421–3435.

    Google Scholar 

  • Horley KJ, Carpenito C, Baker B, Takei F (1989) Molecular cloning of murine intercellular adhesion molecule (ICAM-1). EMBO J 8: 2889–2896.

    PubMed  CAS  Google Scholar 

  • Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH (1995) Cooperative signaling by a5β1 and a4β1 integrins regulates metalloproteinase gene expression in fibroblast adhering to fibronectin. J Cell Biol 129: 867–879.

    Article  PubMed  CAS  Google Scholar 

  • Humphries MJ, Yamada KM, Olden K (1988) Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16–F10 murine melanoma cells. J Clin Invest 81: 782–790.

    Article  PubMed  CAS  Google Scholar 

  • Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25.

    Article  PubMed  CAS  Google Scholar 

  • Iwai K, Ishikura H, Kaji M, Sugiura H, Ishizu A, Takahashi C, Kato H, Tanabe T, Yoshiki T (1993) Importance of E-selectin ELAM-1 and sialyl Lewis-A in adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer 54: 972–977.

    Article  PubMed  CAS  Google Scholar 

  • Johnson RC, Augustin-Voss HG, Zhu D, Pauli BU (1991) Endothelial cell membrane vesicles in the study of organ preference of metastasis. Cancer Res 51: 394–399.

    PubMed  CAS  Google Scholar 

  • Johnson RC, Zhu D, Augustin-Voss HG, Pauli BU (1993) Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells. J Cell Biol 121: 1423–1432.

    Article  PubMed  CAS  Google Scholar 

  • Johnston Gl, Cook RG, McEver RP (1989) Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell 56: 1033–1044.

    Article  Google Scholar 

  • Kinsey DL (1960) An experimental study of preferential metastasis. Cancer 13: 674–676.

    Article  PubMed  CAS  Google Scholar 

  • Lafrenie RM, Buchanan MR, Orr FW (1993) Adhesion molecules and their role in cancer metastasis. Cell Biophysiol 23: 3–89.

    CAS  Google Scholar 

  • Larsen GR, Sako D, Ahem TJ, Shaffer M, Erban J, Sajer SA, Gibson RM, Wagner DD, Furie BC, Furie B (1992) P-selectin and E-selectin: distinct but overlapping leukocyte ligand specificities. J Biol Chem 267: 11104–11110.

    PubMed  CAS  Google Scholar 

  • Lasky LA (1991) Lectin cell adhesion molecules (LEC-CAMs): a new family of cell adhesion proteins involved with inflammation. J Cell Biochem’45: 139–146.

    Article  PubMed  CAS  Google Scholar 

  • Lasky LA, Singer MS, Dowbenko D, Imal Y, Henzel WJ, Grimley C, Fennie C, Gillett H, Watson SR, Rosen SD (1992) An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell 69: 927–938.

    Article  PubMed  CAS  Google Scholar 

  • Lauri D, Martin-Padura I, Biondelli T, Rossi G, Bernasconi S, Giavazzi R, Passerini F, van Hinbergh V, Dejana E (1991 a) Role of beta-1 integrins in tumor cell adhesion to cultured human endothelial cells. Lab Invest 65: 525–531.

    PubMed  CAS  Google Scholar 

  • Lauri D, Needham L, Martin-Padura I, Dejana E (1991b) Tumor cell adhesion to endothelial cells: endothelial-leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells. J Natl Cancer Inst 83: 1321–1324.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence MB, Springer TA (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 859–873.

    Article  PubMed  CAS  Google Scholar 

  • Matsushita Y, Cleary KR, Ota DM, Hoff SD, Irimura T (1990) Sialyl-dimeric Lewis X antigen expressed on mucin-like glycoproteins in colorectal cancer metastases. Lab Invest 63: 780–791.

    PubMed  CAS  Google Scholar 

  • McCarthy SA, Ku I, Gatter KC, Becknell R et al (1991) Heterogeneity of the endothelial cell and its role in organ preference of tumor metastasis. TIPS 12: 462–467.

    PubMed  CAS  Google Scholar 

  • McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF et al (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84: 92–99.

    Article  PubMed  CAS  Google Scholar 

  • Mege RM, Matsuzaki F, Gallin WJ, Goldberg Jl, Cunningham BA, Edelman GM (1988) Construction of epitheloid sheets by transfection of mouse sarcoma cells with cDNA for chicken cell adhesion molecule. Proc Natl Acad Sci USA 85: 7274–7278.

    Article  PubMed  CAS  Google Scholar 

  • Musil LS, Cunningham BA, Edelman GM, Goodenough DA (1990) Differential phosphorylation of the gap junction protein connexin 43 in junctional communication-competent and deficient cell lines. J Cell Biol 111: 2077–2088.

    Article  PubMed  CAS  Google Scholar 

  • Naito S, Giavazzi R, Fidler IJ (1987) Correlation between the in vitro interactions of tumor cells with an organ environment and metastatic behavior in vivo. Invasion Metastasis 7: 126–129.

    Google Scholar 

  • Nicolson GL (1988) Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochim Biophys Acta 948: 175–224.

    PubMed  CAS  Google Scholar 

  • Nicolson GL, Belloni PN, Tressler RJ, Dulski K, Inoue T, Cavanough PG (1989) Adhesive, invasive and growth properties of selected metastatic variants of a murine large cell lymphoma. Invasion Metastasis 9: 102–116.

    PubMed  CAS  Google Scholar 

  • Okahara H, Yagita H, Miyake K, Okumura K (1994) Involvement of very late activation antigen (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor a enhancement of experimental metastasis. Cancer Res 54: 3230–3236.

    Google Scholar 

  • Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1: 571–573.

    Article  Google Scholar 

  • Pauli BU (1995) Consitutitve and inducible endothelial cell adhesion molecules in cancer metastasis. In: Bertino JR (ed) Molecular biology of cancer. Academic, New York (in press).

    Google Scholar 

  • Pauli BU, Lee CL (1988) Organ preference of metastasis: the role of organ-specifically modulated endothelial cells. Lab Invest 58: 379–387.

    PubMed  CAS  Google Scholar 

  • Pauli BU, Augustin-Voss HG, El-Sabban ME, Johnson RC, Hammer DA (1990) Organ preference of metastasis: the role of endothelial cell adhesion molecules. Cancer Metastasis Rev 9: 175–189.

    Article  PubMed  CAS  Google Scholar 

  • Pauli BU, Johnson RC, El-Sabban ME (1991) Organotypic endothelial cell surface molecules mediate organ preference of metastasis. In: Simionescu N, Siminionescu M (eds) Endothelial cell dysfunction. Plenum, New York, pp 439–454.

    Google Scholar 

  • Pauli BU, Johnson RC, Widom J, Cheng CF (1992) Endothelial cell adhesion molecules and their role in organ-preference of metastasis. TiGG 4: 405–414.

    CAS  Google Scholar 

  • Piazza GA, Callanan HM, Mowery J, Hixson DC (1989) Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Biochem J 262: 327–334.

    PubMed  CAS  Google Scholar 

  • Pilewski JM, Albelda SM (1993) Adhesion molecules in the lung. Am Rev Respir Dis 148: 531–537.

    Google Scholar 

  • Qian F, Vaux DL, Weissman IL (1994) Expression of α4β1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell 77: 335–347.

    Article  PubMed  CAS  Google Scholar 

  • Rossi MC, Zetter BR (1992) Selective stimulation of prostatic carcinoma cell proliferation by transferrin. Proc Natl Acad Sci USA 89: 6197–6201.

    Article  PubMed  CAS  Google Scholar 

  • Roskelley CD, Desprez PY, Bissell MJ (1994) Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci USA 91: 12378–12382.

    Article  PubMed  CAS  Google Scholar 

  • Sargent NSE, Oestreicher M, Haidvogl H, Madnick HM, Burger MM (1988) Growth regulation of cancer metastasis by their host organ. Proc Natl Acad Sci USA 85: 7251–7255.

    Article  PubMed  CAS  Google Scholar 

  • Rustgi AK, Daniel K, Podolsky K (1992) The molecular’basis of colon cancer. Annu Rev Med 43: 61–68

    Article  PubMed  CAS  Google Scholar 

  • Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425–434.

    Article  PubMed  CAS  Google Scholar 

  • Stamper HB Jr, Woodruff JJ (1976) Lymphocyte homing into lymph nodes: in vitro demonstration of selective affinity of recirculating lymphocytes to high endothelial venules. J Exp Med 144: 828–833.

    Article  PubMed  Google Scholar 

  • Suter MM, Greenberger LJ, Wilkinson JE, Lewis RM (1990) Differential expression of cell surface antigens of canine keratinocytes defined by monoclonal antibodies. J Histochem Cytochem 38: 541–548.

    Article  PubMed  CAS  Google Scholar 

  • Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R (1993) Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res 53: 354–361.

    PubMed  CAS  Google Scholar 

  • Van Heijne G (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acid Res 14: 4683–4690.

    Article  Google Scholar 

  • Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (1990) Recognition by ELAM-1 of sialyl-Lex determinant on myeloid and tumor cells. Science 250: 1132–1135.

    Article  PubMed  CAS  Google Scholar 

  • Weiss L, Orr FW, Honn KV (1988) Interactions of cancer cells with the microvasculature during metastasis. FASEB J 2: 12–21.

    PubMed  CAS  Google Scholar 

  • Weterman MJ, van Muijen GNP, Bloemers HPJ, Ruiter DJ (1994) Molecular markers of melanocytic tumor progression. Lab Invest 70: 593–608.

    PubMed  CAS  Google Scholar 

  • Zetter BR (1990) The cellular basis of site-specific tumor metastasis. N Engl J Med 322: 605–612.

    Article  PubMed  CAS  Google Scholar 

  • Zhu D, Pauli BU (1991) Generation of monoclonal antibodies directed against organ-specific endothelial cell surface determinants. J Histochem Cytochem 39: 1137–1142.

    Article  PubMed  CAS  Google Scholar 

  • Zhu D, Pauli BU (1993) Correlation between the lung distribution patterns of Lu-ECAM-1 and melanoma experimental metastases. Int J Cancer 53: 628–633.

    Article  PubMed  CAS  Google Scholar 

  • Zhu D, Cheng CF, Pauli BU (1991) Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule. Proc Natl Acad Sci USA 88: 9568–9572.

    Article  PubMed  CAS  Google Scholar 

  • Zhu D, Cheng CF, Pauli BU (1992) Blocking of lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) inhibits murine melanoma lung metastasis. J Clin Invest 89: 1718–1724.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Biology Laboratories, Department of Pathology, Cornell University College of Veterinary Medicine, 14853, Ithaca, NY, USA

    R. C. Elble & B. U. Pauli

Authors
  1. R. C. Elble
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. U. Pauli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., P.D.

  2. Max-βDelbrūck-Centrum für Molekulare Medizin, Robert-Rōssle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Elble, R.C., Pauli, B.U. (1996). Lu-ECAM-1 and DPP IV in Lung Metastasis. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-61107-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64697-3

  • Online ISBN: 978-3-642-61107-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation