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Membrane Type-Matrix Metalloproteinase and Tumor Invasion

  • Chapter
Attempts to Understand Metastasis Formation I

Part of the book series: Current Topics in Microbiology 213/I and Immunology ((CT MICROBIOLOGY,volume 213/1))

Abstract

Matrix metalloproteinases (MMPs) are frequently expressed in a variety of tumor tissues at higher levels than in normal tissues. However, overexpression itself does not mean immediate use of the enzymes for tumor invasion or for the remodeling of the extracellular matrix (ECM), processes associated with tumor growth. MMPs are produced and secreted as zymogens (pro-MMPs) that need proteolytic activation for the enzymes to function (Woessner 1991; Birkedal et al. 1993). Thus, invasive tumor cells should have devices to activate proMMPs to degrade the ECM at the periphery.

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Authors and Affiliations

  1. Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, 920, Berlin, Japan

    M. Seiki

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  1. M. Seiki
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., P.D.

  2. Max-βDelbrūck-Centrum für Molekulare Medizin, Robert-Rōssle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Seiki, M. (1996). Membrane Type-Matrix Metalloproteinase and Tumor Invasion. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-61107-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64697-3

  • Online ISBN: 978-3-642-61107-0

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