Abstract
A key element of the emerging strategy for acute care of stroke is to protect brain tissue from damage until cerebral blood flow can be restored. To that end a number of potential neuroprotective drugs are now in clinical trials.
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References
Pan Y, Lo EH, Matsumoto K, et al (1995) Quantitative and dynamic MRI of neuroprotection in experimental stroke. J Neurological Sciences 131 (2):128–134
Nishikawa T, Kirsch JR, Koehler RC, et al (1994) Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats. Stroke 25:2258–2264
Matsumiya N, Koehler RC, Kirsch JR, et al (1991) Conjugated superoxide dismutase reduces extent of caudate injury after transient focal ischemia in cats. Stroke 22:1193–1200
Nishikawa T, Kirsch JR, Koehler RC, et al (1994) Nitric oxide synthase inhibition reduces caudate injury following transient focal ischemia in cats. Stroke 25:877–885
Maruki Y, Koehler RC, Kirsch JR, et al (1995) Tirilazad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia. J Cerebral Blood Flow & Metabolism 15 (1):88–96
Haseldonckx M, Van Reempts J, Van de Ven M, et al (1997) Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study. Stroke 28 (2):428–432
De Ryck M, Keersmaekers R, Duytschaever H, et al (1996) Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. Journal of Phar-macology & Experimental Therapeutics 279:748–758
Diener HC, Hacke W, Hennerici M, et al (1996) Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group. Stroke 27:76–81
European/Australian Lubeluzole Study
North American Lubeluzole Study
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© 1998 Springer-Verlag Berlin Heidelberg
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Traystman, R.J., Hennerici, M. (1998). Mechanisms of Reversible Injury and Neuroprotection. In: Steiner, T., Hacke, W., Hanley, D.F. (eds) Stroke. Update in Intensive Care and Emergency Medicine, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60264-1_10
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DOI: https://doi.org/10.1007/978-3-642-60264-1_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64326-2
Online ISBN: 978-3-642-60264-1
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