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Adverse Reactions to Iodinated Radiographic Contrast Media

  • Chapter
Book cover Trends in Contrast Media

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Mild adverse reactions to iodinated radiographic contrast media are encountered in as many as 3.7% of patients receiving intravenous injections of low-osmolality and 12.7% of patients receiving intravenous injections of high-osmolality ionic contrast agents (Katayama et al. 1990). Fortunately, the majority of these reactions are mild and clinically insignificant. Severe and very severe reactions (the latter requiring hospitalization) have been noted much less frequently, in only 0.04% and 0.004% of patients receiving intravenous injections of low-osmolality contrast media and 0.22% and 0.04% of patients receiving intravenous injections of high-osmolality contrast media, respectively (Katayama et al. 1990). The vast majority of patients who have severe, even potentially life-threatening, reactions respond to rapid and aggressive treatment (Hartman et al. 1982). Fatal reactions to both types of contrast media are exceedingly rare, having been encountered in as few as 1:170000 patients injected with either agent (Katayama et al. 1990).

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  1. Department of Radiology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA

    R. H. Cohan MD & J. H. Ellis MD

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  1. Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvei 75, DK-2730, Herlev, Denmark

    Henrick S. Thomsen MD

  2. Département de Chimie Organique & Laboratoire RMN, Université de Mons-Hainaut, 24, Avenue du Champ de Mars, B-7000, Mons, Belgium

    Robert N. Muller MD (Professor, Faculté de Médecine) (Professor, Faculté de Médecine)

  3. Department of Radiology, UCSD Medical Center, 200 W. Arbor Drive, 92109-8756, San Diego, CA, USA

    Robert F. Mattrey MD

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Cohan, R.H., Ellis, J.H. (1999). Adverse Reactions to Iodinated Radiographic Contrast Media. In: Thomsen, H.S., Muller, R.N., Mattrey, R.F. (eds) Trends in Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59814-2_11

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