Skip to main content
SpringerLink
Log in
Book cover

ACNE and ROSACEA pp 57–81Cite as

Sebaceous Glands

  • Chapter

  • 545 Accesses

Abstract

The pubertal increase in sebum secretion is a prerequisite in the pathogenesis of acne vulgaris. Almost all acne patients suffer from seborrhea, that is, sebum production well above the mean for normals. However, not all individuals with seborrhea suffer from acne. Acne does not occur when sebum excretion is low. The uniform efficacy of sebosuppressive drugs such as systemic estrogens, antiandrogens, and isotretinoin confirms the importance of sebum in the pathogenesis of acne.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agache P, Blanc D, Barrand C, Laurent R (1980) Sebum levels during the first year of life. Br J Dermatol 103: 643–649

    Article  PubMed  CAS  Google Scholar 

  • Bickers DR (1983) Drug, carcinogen, and steroid hormone metabolism in the skin. In: Goldsmith LA (ed) Biochemistry and physiology of the skin, chap 52. Oxford University Press, New York, pp 1169–1186

    Google Scholar 

  • Bauer M, Vaalasti A, Pauli SL, Ylikomi T, Joensuu T, Tuohimaa P (1991) Location of androgen receptor in human skin. J Invest Dermatol 97: 264–268

    Article  Google Scholar 

  • Burton JL, Cunliffe WJ, Shuster S (1970) Circadian rhythm in sebum secretion. Br J Dermatol 82: 497–501

    Article  PubMed  CAS  Google Scholar 

  • Burton JL, Cunliffe WJ, Saunders IG, Shuster S (1971) The effect of facial nerve paresis on sebum secretion. Br J Dermatol 84: 135–138

    Article  PubMed  CAS  Google Scholar 

  • Burton JL, Cartlidge M, Cartlidge NEF, Shuster S (1973) Sebum excretion in parkinsonism. Br J Dermatol 88: 263–266

    Article  PubMed  CAS  Google Scholar 

  • Cunliffe WJ, Burton Jl, Shuster S (1970) The effect of local temperature variations on the sebum excretion rate. Br J Dermatol 83: 650–654

    Article  PubMed  CAS  Google Scholar 

  • Cunliffe WJ, Kearney JN, Simpson NB (1980) A modified photometric technique for measuring sebum excretion rate. J Invest Dermatol 75: 394–398

    Article  PubMed  CAS  Google Scholar 

  • Cunliffe WJ, Stainton C, Forster RA (1983) Topical benzoyl peroxide increases sebum secretion rate in patients with acne. Br J Dermatol 109: 577–579

    Article  PubMed  CAS  Google Scholar 

  • Demetree JW, Safer LF, Artis WM (1980) The effect of zinc on the sebum secretion rate. Acta Derm Venereol (Stockh) 60: 166–169

    CAS  Google Scholar 

  • Downing DT, Strauss JS, Ramastry P, Abel M, Lees CW, Pochi PE (1975) Measurement of the time between synthesis and surface excretion of sebaceous lipids in sheep and man. J Invest Dermatol 64: 215–219

    Article  PubMed  CAS  Google Scholar 

  • Downing DT, Stewart ME, Strauss JS (1986) Changes in sebum secretion and the sebaceous gland. Dermatol Clin 4: 419–423

    PubMed  CAS  Google Scholar 

  • Downing DT, Stewart ME, Wertz PW, Strauss JS (1986) Essential fatty acids and acne. J Am Acad Dermatol 14: 221–225

    Article  PubMed  CAS  Google Scholar 

  • Drucker WD, Blumberg AM, Gandy HM, David RR, Verde AL (1972) Biological activity of dehydroepiandrosterone sulfate. J Clin Endocrinol Metabol 35: 48–54

    Article  CAS  Google Scholar 

  • Fanta D (1990) Cyproterone acetate in acne. J Dermatol Treat 1 [Suppl 3]: S19–S22

    Article  Google Scholar 

  • Fulton JE, Plewig G, Kligman AM (1970) Effect of chocolate on acne vulgaris. JAMA 210: 2071–2074

    Article  Google Scholar 

  • Goldstein JA, Pochi PE (1981) Failure of benzoyl peroxide to decrease sebaceous gland secretion in acne. Dermatologica 162: 287–291

    Article  PubMed  CAS  Google Scholar 

  • Goolamali SK, Burton JL, Shuster S (1973) Sebum excretion in hypopituitarism. Br J Dermatol 89: 21–24

    Article  PubMed  CAS  Google Scholar 

  • Greene RS, Downing DT, Pochi PS, Strauss JS (1970) Anatomical variation in the amount and composition of human skin surface lipids. J Invest Dermatol 54: 240–247

    Article  PubMed  CAS  Google Scholar 

  • Gruber DM, Sator MO, Joura EA, Kokoschka EM, Heinze G, Huber JC (1998) Topical cyproterone acetate treatment in women with acne: a placebo-controlled trial. Arch Dermatol 134: 459–463

    Article  PubMed  CAS  Google Scholar 

  • Harris HH, Downing DT, Stewart ME, Strauss JS (1983) Sustainable rates of sebum secretion in acne patients and matched normal control subjects. J Am Acad Dermatol 8: 200–203

    Article  PubMed  CAS  Google Scholar 

  • Jenkinson M, McEwan D, Elder HY, Montgomery I, Moss VA (1985) Comparative studies of the ultrastructure of the sebaceous gland. Tissue Cell 17: 683–698

    Article  PubMed  CAS  Google Scholar 

  • Lookingbill DP, Cunliffe WJ (1986) A direct gravimetric technique for measuring sebum excretion rate. Br J Dermatol 114: 75–81

    Article  PubMed  CAS  Google Scholar 

  • Melnik B, Kinner T, Plewig G (1988) Influence of oral isotretinoin treatment on the composition of comedonal lipids: implications for comedogenesis in acne vulgaris. Arch Dermatol Res 280: 97–102

    Article  PubMed  CAS  Google Scholar 

  • Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT (1988) Fatty acids of acylceramides from comedones and from the skin surface of acne patients. J Invest Dermatol 90: 350–353

    Article  PubMed  CAS  Google Scholar 

  • Pièrard GE (1986) Follicle to follicle heterogeneity of sebum excretion. Dermatologica 173: 61–65

    Article  PubMed  Google Scholar 

  • Pièrard GE, Kligman AM (1989) An update of the SebutapeR technique. In: Marks R, Plewig G (eds) Acne and related disorders. Dunitz, London, pp 111–112

    Google Scholar 

  • Pièrard-Franchimont C, Pièrard GE, Kligman AM (1990) Seasonal modulation of sebum excretion. Dermatologia 181: 21–22

    Article  Google Scholar 

  • Plewig G, Christophers E (1974) Renewal rate of human sebaceous glands. Acta Derm Venereol (Stockh) 54:177–182

    CAS  Google Scholar 

  • Plewig G, Christophers E, Braun-Falco O (1971) Cell transition time of human sebaceous glands. Acta Derm Venereol (Stockh) 51: 423–428

    CAS  Google Scholar 

  • Plewig G, Christophers E, Braun-Falco O (1971) Proliferative cells in the human sebaceous gland. Labelling index and regional variations. Acta Derm Venereol (Stockh) 51: 413–422

    Google Scholar 

  • Pochi PE (1983) Hormonal therapy of acne. Dermatol Clin 1: 377–384

    Google Scholar 

  • Press MF, Greene GL (1988) Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinol 122: 1165–1175

    Article  CAS  Google Scholar 

  • Saint-Leger D, Berrebi C, Duboz C, Agache P (1979) Lipometre: an easy tool for rapid quantitation of skin surface lipids (SSL) in man. Arch Dermatol Res 265: 79–89

    Google Scholar 

  • Schaefer H, Kuhn-Bussius H (1970) Methodik zur quantitativen Bestimmung der menschlichen Talgsekretion. Arch Klin Exp Dermatol 238: 429–435

    Article  PubMed  CAS  Google Scholar 

  • Shaw JC (1991) Spironolactone in dermatologic therapy. J Am Acad Dermatol 24: 236–243

    Article  PubMed  CAS  Google Scholar 

  • Shuster S, Hinks WM, Thody AJ (1977) Effect of sex and age at gonadectomy on the sebaceous response to progesterone. J Endocrinol 73: 67–70

    Article  PubMed  CAS  Google Scholar 

  • Stewart ME (1992) Sebaceous gland lipids. Semin Dermatol 11: 100–105

    PubMed  CAS  Google Scholar 

  • Stewart ME, Downing DT (1985) Measurement of sebum secretion rates in young children. J Invest Dermatol 84: 59–61

    Article  PubMed  CAS  Google Scholar 

  • Stewart ME, Benoit AM, Downing DT, Strauss JS (1984) Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. J Invest Dermatol 82: 74–78

    Article  PubMed  CAS  Google Scholar 

  • Stewart ME, Grahek MO, Cambier LS, Wertz PW, Downing DT (1986) Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. J Invest Dermatol 87: 733–736

    Article  PubMed  CAS  Google Scholar 

  • Stewart ME, McDonnell MW, Downing DT (1986) Possible genetic control of the proportions of branched chain fatty acids in human sebaceous wax esters. J Invest Dermatol 86: 706–708

    Article  PubMed  CAS  Google Scholar 

  • Strauss JS, Pochi P (1961) The quantitative gravimetric determination of sebum production. J Invest Dermatol 36: 293–298

    Google Scholar 

  • Tosti A (1974) A comparison of the histodynamics of sebaceous glands and epidermis in man: a microanatomic and morphometric study. J Invest Dermatol 62:147–152

    Google Scholar 

  • Walton S, Wyatt EH, Cunliffe WJ (1988) Genetic control of sebum excretion and acne - a twin study. Br J Dermatol 118: 393–396

    Article  PubMed  CAS  Google Scholar 

  • Wheatley VR (1986) The sebaceous glands. In: Jarrett A (ed) The physiology and pathophysiology of the skin, vol 9. Academic, San Diego, pp 2705–2971

    Google Scholar 

  • Williams M, Cunliffe WJ, Williamson B, Forster RA, Cotterill JA, Edwards JC (1973) Effect of local temperature changes on sebum excretion rate and forehead surface lipids composition. Br J Dermatol 88: 257–262

    Article  PubMed  CAS  Google Scholar 

  • Yardley HJ, Summerly R (1981) Lipid composition and metabolism in normal and diseased epidermis. Pharmacol Ther 13: 357–383

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie Klinikum München, Ludwig-Maximilians-Universität München, D-80337, München, Germany

    Prof. Dr. med. Gerd Plewig

  2. Department of Dermatology, University of Pennsylvania, 226 Clinical Research Building 422 Curie Boulevard, Philadelphia, PA, 19104-6142, USA

    Albert M. Kligman M.D., Ph. D.

Authors
  1. Prof. Dr. med. Gerd Plewig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Albert M. Kligman M.D., Ph. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Plewig, G., Kligman, A.M. (2000). Sebaceous Glands. In: ACNE and ROSACEA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59715-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59715-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66751-3

  • Online ISBN: 978-3-642-59715-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation