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Poly (ADP-Ribose) Synthetase as a Novel Therapeutic Target for Circulatory Shock

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Book cover Yearbook of Intensive Care and Emergency Medicine 2001

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 2001 ((YEARBOOK,volume 2001))

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Abstract

Poly (ADP-ribose) synthetase (PARS), also known as poly(ADP-ribose) polymerase (PARP), is an abundant nuclear enzyme present throughout the phylogenetic spectrum [1]. The precise physiologic roles of PARS remain undefined; its traditional role as a DNA-repair enzyme has been questioned by recent studies [2]. PARS appears to play diverse roles, participating in DNA repair [3,4], chromatin relaxation [5], cell differentiation [6], DNA replication [7], transcriptional regulation [8], control of cell cycle [9], p53 expression and apoptosis [10], and transformation [11]. In the last decade, the novel concept has emerged that in circulatory shock, and various other pathophysiological conditions, PARS plays a crucial role in the regulation and generation of the inflammatory response and cell and organ injury. Here we summarize the evidence favoring this new role for PARS in circulatory shock and evaluate the therapeutic opportunities afforded by PARS inhibition.

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Authors
  1. L. Liaudet
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  2. F. G. Soriano
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  3. C. Szabó
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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Liaudet, L., Soriano, F.G., Szabó, C. (2001). Poly (ADP-Ribose) Synthetase as a Novel Therapeutic Target for Circulatory Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2001. Yearbook of Intensive Care and Emergency Medicine 2001, vol 2001. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59467-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-59467-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41407-0

  • Online ISBN: 978-3-642-59467-0

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