2004, pp 29-40

Pathophysiology of Chronic Wounds

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Abstract

The normal response to tissue injury is a timely and orderly reparative process that results in sustained restoration of anatomical and functional integrity [1]. Wound repair, however, is not a simple linear process but rather a complex integration of dynamic interactive processes involving cell-cell and cell-matrix interactions mediated by humoral messengers [2,3]. Unencumbered, these processes follow a specific time sequence or chronology [2]. Although the timing of the various processes is usually orderly, it is not mutually exclusive and there is a varying overlap in time [3,4].