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Mechanisms of Organ Dysfunction in Critical Illness pp 282–300Cite as

Mechanisms Responsible for Intestinal Barrier Dysfunction in Critical Illness

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 38))

Abstract

The intestine, apart from serving as a portal of entry for nutrients and water into the body, also acts as a barrier limiting the systemic absorption of intraluminal microbes and microbial products. Results from laboratory and clinical studies suggest that numerous conditions, including sepsis, pancreatitis, and trauma can lead to derangements in the barrier function of the gut. It has been hypothesized that leakage of gut-derived pathogens and/or pro-inflammatory products into the lamina propria, mesenteric lymph, or blood stream can initiate or promote systemic inflammation.

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Authors and Affiliations

  1. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall, Room 616 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    R. Venkataraman & M. P. Fink

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  1. R. Venkataraman
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  2. M. P. Fink
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  1. Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans

  2. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall, Room 606, 3550 Terrace Street, Pittsburgh, PA, 15264, USA

    Mitchell P. Fink

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Venkataraman, R., Fink, M.P. (2002). Mechanisms Responsible for Intestinal Barrier Dysfunction in Critical Illness. In: Evans, T.W., Fink, M.P. (eds) Mechanisms of Organ Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56107-8_20

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  • DOI: https://doi.org/10.1007/978-3-642-56107-8_20

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