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Ischemia-Induced Derangements in the Actin Cytoskeleton: Mechanisms and Functional Significance

  • Chapter
Mechanisms of Organ Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICMSOFT,volume 38))

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Abstract

Ischemia remains the leading cause of acute renal failure in adults [1, 2]. To fully understand acute renal failure and devise optimal treatment regimens, it is necessary to have knowledge of the mechanisms of cellular injury and their effects on organ function. Therefore, the focus of this chapter will be to present the current understanding of the mechanisms of cellular injury emphasizing the structural, physiological, and biochemical changes that occur in proximal tubule cells as a result of ischemic injury. Special emphasis will be given to the mechanism of actin alterations during ischemia. These changes play a major mechanistic role in the pathophysiology of the decreased glomerular filtration rate (GFR) and ion transport that are the hallmarks of acute renal failure.

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Authors and Affiliations

  1. Department of Medicine Division of Nephrology, Indiana University School of Medicine Roudebush VA Medical Center, Indianapolis, IN, 46202, USA

    B. A. Molitoris, S. L. Ashworth & T. A. Sutton

Authors
  1. B. A. Molitoris
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  2. S. L. Ashworth
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  3. T. A. Sutton
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Editor information

Editors and Affiliations

  1. Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans

  2. Division of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall, Room 606, 3550 Terrace Street, Pittsburgh, PA, 15264, USA

    Mitchell P. Fink

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© 2002 Springer-Verlag Berlin Heidelberg

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Molitoris, B.A., Ashworth, S.L., Sutton, T.A. (2002). Ischemia-Induced Derangements in the Actin Cytoskeleton: Mechanisms and Functional Significance. In: Evans, T.W., Fink, M.P. (eds) Mechanisms of Organ Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56107-8_16

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  • DOI: https://doi.org/10.1007/978-3-642-56107-8_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42692-9

  • Online ISBN: 978-3-642-56107-8

  • eBook Packages: Springer Book Archive

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