Chapter

Protein Complexes that Modify Chromatin

Volume 274 of the series Current Topics in Microbiology and Immunology pp 203-236

The MYST Family of Histone Acetyltransferases

  • R. T. UtleyAffiliated withLaval University Cancer Research Center, Hôtel-Dieu de Quebec (CHUQ)
  • , J. CôtéAffiliated withLaval University Cancer Research Center, Hôtel-Dieu de Quebec (CHUQ)

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Abstract

Multiple chromatin modifying proteins and multisubunit complexes have been characterized in recent Years. Histone acetyltransferase (HAT) activities have been the most thoroughly studied, both biochemically and functionally. This review sums up the current knowledge on a specific group of proteins that is extremely well conserved throughout evolution, the MYST family of histone acetyltransferases. These proteins play critical roles in various nuclear functions and the control of cell proliferation.