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Vitamin D Analogs in Cancer Prevention and Therapy pp 123–134Cite as

A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 164))

Abstract

1α,25-Dihydroxyvitamin D3(1α,(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1α,(OH)2D3alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

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  1. Departments of Medicine, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, 911A Guggenheim Building, 200 First Street S.W., Rochester, MN, 55905, USA

    Rajiv Kumar

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  2. Mark R. Pittelkow
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  5. Hee-Jeong Im
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  7. David Schilling
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  1. Hautklinik und Poliklinik der Universitätskliniken des Saarlandes, Kirrberger Str., 66421, Homburg/Saar

    Jörg Reichrath  & Wolfgang Tilgen  & 

  2. Frauenklinik des Universitätsklinikums der Eberhard-Karls-Universität, Calwerstr. 7, 71076, Tübingen

    Michael Friedrich

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Kumar, R. et al. (2003). A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis. In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-55580-0_8

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