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PET and SPECT in Neurology pp 323–337Cite as

Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer’s Disease, with Particular Emphasis on Guidelines

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Abstract

Dementia is a clinical diagnosis reflecting many possible underlying pathologies, including, for example, vascular dementia and neurodegenerative disorders such as frontotemporal dementia, Lewy body-type disorder or Alzheimer’s disease (AD). The breakthrough of 99mtechnetium-labelled perfusion tracers in the 1990s resulted in many SPECT studies of flow changes in AD. In the first decade of 2000, the role of perfusion SPECT was shifted from diagnosis towards differential diagnosis, parallel to the growing attention for diagnosing early stages of dementia. This evolution is reflected in the upcoming guidelines, which are detailed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Ronald W. J. van Rheenen

  2. Department of Neurology, Medisch Spectrum Twente, Haaksbergerstraat 55, Enschede, 7513 ER, The Netherlands

    Jacoba P. van Amerongen

  3. Division of Biomedical Engineering, Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Badstrasse 24, Offenburg, 77652, Germany

    Andreas Otte

  4. Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Born Bunge Foundation, Universiteitsplein 1, B-2610, Antwerp (Wilrijk), Belgium

    Peter Paul De Deyn

  5. Department of Neurology, Alzheimer Research Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Peter Paul De Deyn

  6. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Rudi A. J. O. Dierckx

  7. Department of Radiology and Nuclear Medicine, Ghent University, De Pintelaan 185 K12, Ghent, 9000, Belgium

    Rudi A. J. O. Dierckx

Authors
  1. Ronald W. J. van Rheenen
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  2. Jacoba P. van Amerongen
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  3. Andreas Otte
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  4. Peter Paul De Deyn
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  5. Rudi A. J. O. Dierckx
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Corresponding author

Correspondence to Ronald W. J. van Rheenen .

Editor information

Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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van Rheenen, R.W.J., van Amerongen, J.P., Otte, A., De Deyn, P.P., Dierckx, R.A.J.O. (2014). Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer’s Disease, with Particular Emphasis on Guidelines. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-54307-4_14

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