Abstract
Jerne (1974) introduced the idea that the immune system is regulated by idiotypic interactions. When an antigen (Ag) is encountered by the immune system an immune response normally results, with the antibodies (Ab) directed against the antigen called Ab1 or first level antibodies. Jerne suggested that the unique or idiotypic portions of these Ab1 antibodies would act as antigens and induce an anti-idiotypic immune response resulting in the production of Ab2 antibodies. These in turn could induce third level antibodies, etc., so that an entire network of interactions might be involved in the response.
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© 1994 Springer-Verlag Berlin Heidelberg
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Rose, R., Perelson, A.S. (1994). Immune Networks and Immune Responses. In: Levin, S.A. (eds) Frontiers in Mathematical Biology. Lecture Notes in Biomathematics, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50124-1_9
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DOI: https://doi.org/10.1007/978-3-642-50124-1_9
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