Abstract
Adipose tissue contains a large portion of stem cells that are primarily derived from the stromal cell fraction or from the dedifferentiation of mature (lipid filled) adipocytes. Stem cells that may give rise to adipocytes are also derived from skeletal muscle, bone, and a variety of other tissues. Knowledge of these cells may prove beneficial in cell-based therapies for tissue repair, regeneration, or engineering.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Hausman GJ, Dodson MV, Ajuwon K, Azain M, Barnes K, Guan LL, Jiang Z, Poulos S, Sainz RD, Smith S, Spurlock M, Novakofski J, Fernyhough ME, Bergen WG. Board invited review: the biology and regulation of preadipocytes and adipocytes in meat animals. J Anim Sci. 2009;87(4):1218–46.
Xu Y, Zhu MJ, Dodson MV, Du M. Developmental programming of fetal skeletal muscle and adipose tissue development. J Genomics. 2012;1:29–38.
Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999;4(4):611–7.
Fernyhough ME, Okine E, Hausman G, Vierck JL, Dodson MV. PPAR-gamma and GLUT-4 expression as differentiation markers for preadipocyte conversion to become an adipocyte. Domest Anim Endocrinol. 2007;33(4):367–78.
Du M, Yan X, Tong JF, Zhao J, Zhu MJ. Maternal obesity, inflammation, and fetal skeletal muscle development. Biol Reprod. 2009;82(1):4–12.
Hausman GJ, Poulos SP. Adipose tissue development in extramuscular and intramuscular depots. In: Du M, McCormick RJ, editors. Applied muscle biology and meat science. Boca Raton: CRC Press; 2009. p. 67–81.
Hausman GJ, Dodson MV. Stromal vascular cells and adipogenesis: cells within adipose depots regulate adipogenesis. J Genomics. 2012;1(1):56–66.
Hausman DB, DiGirolamo M, Bartnessm TJ, Hausmann GJ, Martin RJ. The biology of white adipocyte proliferation. Obes Rev. 2001;2(4):239–54.
Salvadori C, Peters IR, Day MJ, Engvall E, Shelton GD. Muscle regeneration, inflammation, and connective tissue expansion in canine inflammatory myopathy. Muscle Nerve. 2005;31(2):192–8.
Chen YW, Nagaraju K, Bakay M, McIntyre O, Rawat R, Shi R, Hoffman EP. Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. Neurology. 2005;65(6):826–34.
Decologne N, Kolb M, Margetts PJ, Menetrier F, Artur Y, Garrido C, Gauldie J, Camus P, Bonniaud P. TGF-beta1 induces progressive pleural scarring and subpleural fibrosis. J Immunol. 2007;179(9):6043–51.
Gosselin LE, Williams JE, Deering M, Brazeau D, Koury S, Martinez DA. Localization and early time course of TGF-beta-1mRNA expression in dystrophic muscle. Muscle Nerve. 2004;30(5):645–53.
Tu AW, Luo K. Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response. J Biol Chem. 2007;282(29):21187–96.
Kennedy L, Shi-Wen X, Carter DE, Abraham DJ, Leask A. Fibroblast adhesion results in the induction of a matrix remodeling gene expression program. Matrix Biol. 2008;27(4):274–81.
Foidart M, Foidart JM, Engel WK. Collagen localization in normal and fibrotic human skeletal muscle. Arch Neurol. 1981;38(3):152–7.
Dodson MV, Hausman GJ, Guan LL, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC, Rhoadsn RP, Soret B, Reecy JM, Velleman SG, Jiang Z. Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. Int J Biol Sci. 2010;6(7):682–90.
Dodson MV, Hausman GJ, Guan LL, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC, Rhoads RP, Soret B, Reecy JM, Velleman SG, Jiang Z. Skeletal muscle stem cells from animals I. Basic cell biology. Int J Biol Sci. 2010;6(5):465–74.
Poulos SP, Dodson MV, Hausman GJ. Cell line models of preadipocytes and adipocytes. Exp Biol Med. 2010;235(10):1185–93.
Storck R, Spitzer JA. Metabolism of isolated fat cells from various tissue sites in the rat: influence of hemorrhagic hypotension. J Lipid Res. 1974;15:200–5.
Fernyhough ME, Vierck JL, Hausmann GJ, Mir PS, Okine EK, Dodson MV. Primary adipocyte culture: adipocyte purification methods may lead to a new understanding of adipose tissue growth and development. Cytotechnology. 2004;46(2–3):163–72.
Fernyhough ME, Hausman GJ, Dodson MV. Progeny from dedifferentiated bovine adipocytes display protracted adipogenesis. Cells Tissues Organs. 2008;188(4):359–72.
Dodson MV, Fernyhough ME. Mature adipocytes: are there still novel things that we can learn from them? Tissue Cell. 2008;40(4):307–8.
Prunet-Marcassus B, Cousin B, Caton D, Andre M, Penicaud L, Casteilla L. From heterogeneity to plasticity in adipose tissues: site-specific differences. Exp Cell Res. 2006;312(6):727–36.
Fernyhough ME, Hausman GJ, Guan LL, Okine E, Moore SS, Dodson MV. Mature adipocytes may be a source of stem cells for tissue engineering. Biochem Biophys Res Commun. 2008;368(3):455–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Dodson, M.V. et al. (2014). Adipose Cell Precursors: Stem Cells in Medicine, Tissue Engineering, and Reconstructive Surgery. In: Shiffman, M., Di Giuseppe, A., Bassetto, F. (eds) Stem Cells in Aesthetic Procedures. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45207-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-45207-9_2
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-45206-2
Online ISBN: 978-3-642-45207-9
eBook Packages: MedicineMedicine (R0)